Literature DB >> 30369745

Eltrombopag For Immune Thrombocytopenic Children in a Single Region.

Göksel Leblebisatan1, Yurdanur Kilinc1, Metin Cil1, İlgen Sasmaz1, Ayse Ozkan2.   

Abstract

Objective Child patients of chronic thrombocytopenic purpura with severe and resistant thrombocytopenia were evaluated to observe whether their clinical or laboratory states improve by one of the thrombomimetic therapeutic agent called Eltrombopag as in adults in a single center of different country from previous studies. Materials and Methods Nineteen patients with chronic immune thrombocytopenia were treated with Eltrombopag to dose in international guidelines. Results Approximately half (11/19:58%) of the patients benefitted from the treatment with Eltrombopag either by an increase of platelet levels at safe levels with a decrease in the frequency of bleedings which needed rescue treatment. Conclusion Thrombomimetic treatment options have strengthened the clinician's hand where the regular treatment options became insufficient.

Entities:  

Keywords:  Children; Eltrombopag; Immune thrombocytopenia

Year:  2018        PMID: 30369745      PMCID: PMC6186233          DOI: 10.1007/s12288-018-0928-y

Source DB:  PubMed          Journal:  Indian J Hematol Blood Transfus        ISSN: 0971-4502            Impact factor:   0.900


  18 in total

1.  Successful Use of Eltrombopag in a Child With Hurler Syndrome After Haploidentical Hematopoietic Stem Cell Transplantation.

Authors:  Rahul Naithani; Mansi Sachdev; Rajiv Uttam
Journal:  J Pediatr Hematol Oncol       Date:  2016-03       Impact factor: 1.289

2.  TPO-RAs in pITP: description of a case series and analysis of predictive factors for response.

Authors:  Maria Gabriella Mazzucconi; Cristina Santoro; Erminia Baldacci; Federico De Angelis; Marta Chisini; Grazia Ferrara; Paola Volpicelli; Roberto Foà
Journal:  Eur J Haematol       Date:  2016-11-18       Impact factor: 2.997

3.  Bleeding tendency and platelet function during treatment with romiplostim in children with severe immune thrombocytopenic purpura.

Authors:  Elena V Suntsova; Irina M Demina; Anastasia A Ignatova; Nikolay M Ershov; Natalia M Trubina; Juliya Dobrynina; Irina V Serkova; Zhanna S Supik; Ekaterina V Orekhova; Lili A Hachatryan; Natalia N Kotskaya; Aleksey V Pshonkin; Aleksey A Maschan; Galina A Novichkova; Mikhail A Panteleev
Journal:  Int J Hematol       Date:  2017-03-07       Impact factor: 2.490

Review 4.  A practical guide to the use of eltrombopag in children with chronic immune thrombocytopenia.

Authors:  John D Grainger; Sharon Thind
Journal:  Pediatr Hematol Oncol       Date:  2017-05-24       Impact factor: 1.969

5.  Eltrombopag for secondary failure of platelet recovery post-allogeneic hematopoietic stem cell transplant in children.

Authors:  Salah Ali; Adam Gassas; Melanie Kirby-Allen; Joerg Krueger; Muhammad Ali; Tal Schechter
Journal:  Pediatr Transplant       Date:  2017-06-27

6.  Severe bleeding in idiopathic thrombocytopenic purpura.

Authors:  Paula Bolton-Maggs
Journal:  J Pediatr Hematol Oncol       Date:  2003-12       Impact factor: 1.289

7.  Thrombopoietin Receptor Agonist Use in Children: Data From the Pediatric ITP Consortium of North America ICON2 Study.

Authors:  Cindy Neunert; Jenny Despotovic; Kristina Haley; Michele P Lambert; Kerri Nottage; Kristin Shimano; Carolyn Bennett; Robert Klaassen; Kimo Stine; Alexis Thompson; Yves Pastore; Travis Brown; Peter W Forbes; Rachael F Grace
Journal:  Pediatr Blood Cancer       Date:  2016-05-02       Impact factor: 3.167

8.  [Clinical study of pulsed high- dose dexamethasone treatment in 38 children with primary immune thrombocytopenic purpura].

Authors:  J Ma; L L Fu; Z P Chen; J Y Ma; R Zhang; Y Su; L Zhang; Y Y Wei; R H Wu
Journal:  Zhonghua Xue Ye Xue Za Zhi       Date:  2016-10-14

Review 9.  Use of Thrombopoietin Receptor Agonists in Childhood Immune Thrombocytopenia.

Authors:  Angelica Maria Garzon; William Beau Mitchell
Journal:  Front Pediatr       Date:  2015-08-13       Impact factor: 3.418

10.  Eltrombopag for the Treatment of Immune Thrombocytopenia: The Aegean Region of Turkey Experience.

Authors:  Füsun Özdemirkıran; Bahriye Payzın; H Demet Kiper; Sibel Kabukçu; Gülsüm Akgün Çağlıyan; Selda Kahraman; Ömür Gökmen Sevindik; Cengiz Ceylan; Gürhan Kadıköylü; Fahri Şahin; Ali Keskin; Öykü Arslan; Mehmet Ali Özcan; Gülnur Kabukçu; Gülsüm Görgün; Zahit Bolaman; Filiz Büyükkeçeci; Oktay Bilgir; İnci Alacacıoğlu; Filiz Vural; Murat Tombuloğlu; Zafer Gökgöz; Güray Saydam
Journal:  Turk J Haematol       Date:  2015-04-27       Impact factor: 1.831

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