Lindsay R Clark1, Rebecca L Koscik2, Samantha L Allison3, Sara E Berman4, Derek Norton5, Cynthia M Carlsson6, Tobey J Betthauser7, Barbara B Bendlin3, Bradley T Christian7, Nathaniel A Chin3, Sanjay Asthana8, Sterling C Johnson6. 1. Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Wisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, WI, USA. Electronic address: lrclark@medicine.wisc.edu. 2. Wisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. 3. Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. 4. Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Medical Scientist and Neuroscience Training Programs, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. 5. Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Department of Biostatistics and Medical Informatics, University of Wisconsin, Madison, WI, USA. 6. Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Wisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, WI, USA. 7. Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Waisman Center and Department of Medical Physics, University of Wisconsin, Madison, WI, USA. 8. Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, WI, USA.
Abstract
BACKGROUND: This study tested if central obesity, hypertension, or depressive symptoms moderated the relationship between β-amyloid (Aβ) and longitudinal cognitive performance in late middle-aged adults enriched for Alzheimer's disease (AD) risk. METHODS: Participants (n = 207; ages = 40-70 years; 73% parental AD) in the Wisconsin Registry for Alzheimer's Prevention study completed 3+ neuropsychological evaluations and a [11C]PiB positron emission tomography scan or lumbar puncture. Linear mixed-effects regression models tested interactions of risk factor × Aβ × visit age on longitudinal Verbal Learning & Memory and Speed & Flexibility factor scores. RESULTS: The relationship between Aβ and Verbal Learning & Memory decline was moderated by hypertension (χ2(1) = 3.85, P = .04) and obesity (χ2(1) = 6.12, P = .01); those with both elevated Aβ and the risk factor declined at faster rates than those with only elevated Aβ or elevated risk factors. CONCLUSION: In this cohort, hypertension and obesity moderated the relationship between Aβ and cognitive decline. Published by Elsevier Inc.
BACKGROUND: This study tested if central obesity, hypertension, or depressive symptoms moderated the relationship between β-amyloid (Aβ) and longitudinal cognitive performance in late middle-aged adults enriched for Alzheimer's disease (AD) risk. METHODS:Participants (n = 207; ages = 40-70 years; 73% parental AD) in the Wisconsin Registry for Alzheimer's Prevention study completed 3+ neuropsychological evaluations and a [11C]PiB positron emission tomography scan or lumbar puncture. Linear mixed-effects regression models tested interactions of risk factor × Aβ × visit age on longitudinal Verbal Learning & Memory and Speed & Flexibility factor scores. RESULTS: The relationship between Aβ and Verbal Learning & Memory decline was moderated by hypertension (χ2(1) = 3.85, P = .04) and obesity (χ2(1) = 6.12, P = .01); those with both elevated Aβ and the risk factor declined at faster rates than those with only elevated Aβ or elevated risk factors. CONCLUSION: In this cohort, hypertension and obesity moderated the relationship between Aβ and cognitive decline. Published by Elsevier Inc.
Authors: C M Roe; A M Fagan; M M Williams; N Ghoshal; M Aeschleman; E A Grant; D S Marcus; M A Mintun; D M Holtzman; J C Morris Journal: Neurology Date: 2011-01-12 Impact factor: 9.910
Authors: Bernhard Haring; Chunyuan Wu; Laura H Coker; Arjun Seth; Linda Snetselaar; JoAnn E Manson; Jacques E Rossouw; Sylvia Wassertheil-Smoller Journal: Am J Hypertens Date: 2015-07-01 Impact factor: 2.689
Authors: Michael C Donohue; Reisa A Sperling; Ronald Petersen; Chung-Kai Sun; Michael W Weiner; Paul S Aisen Journal: JAMA Date: 2017-06-13 Impact factor: 56.272
Authors: Tiia Ngandu; Jenni Lehtisalo; Alina Solomon; Esko Levälahti; Satu Ahtiluoto; Riitta Antikainen; Lars Bäckman; Tuomo Hänninen; Antti Jula; Tiina Laatikainen; Jaana Lindström; Francesca Mangialasche; Teemu Paajanen; Satu Pajala; Markku Peltonen; Rainer Rauramaa; Anna Stigsdotter-Neely; Timo Strandberg; Jaakko Tuomilehto; Hilkka Soininen; Miia Kivipelto Journal: Lancet Date: 2015-03-12 Impact factor: 79.321
Authors: Ana Verdelho; Sofia Madureira; Carla Moleiro; José M Ferro; John T O'Brien; Anna Poggesi; Leonardo Pantoni; Franz Fazekas; Philip Scheltens; Gunhild Waldemar; Anders Wallin; Timo Erkinjuntti; Domenico Inzitari Journal: J Neurol Neurosurg Psychiatry Date: 2013-05-28 Impact factor: 10.154
Authors: Y-F Chuang; Y An; M Bilgel; D F Wong; J C Troncoso; R J O'Brien; J C Breitner; L Ferruci; S M Resnick; M Thambisetty Journal: Mol Psychiatry Date: 2015-09-01 Impact factor: 15.992
Authors: Yonas E Geda; Rosebud O Roberts; Michelle M Mielke; David S Knopman; Teresa J H Christianson; Vernon S Pankratz; Bradley F Boeve; Ondrej Sochor; Eric G Tangalos; Ronald C Petersen; Walter A Rocca Journal: Am J Psychiatry Date: 2014-05 Impact factor: 18.112
Authors: Sterling C Johnson; Rebecca L Koscik; Erin M Jonaitis; Lindsay R Clark; Kimberly D Mueller; Sara E Berman; Barbara B Bendlin; Corinne D Engelman; Ozioma C Okonkwo; Kirk J Hogan; Sanjay Asthana; Cynthia M Carlsson; Bruce P Hermann; Mark A Sager Journal: Alzheimers Dement (Amst) Date: 2017-12-08
Authors: Laura C Chambers; Janice M Diaz-Otero; Courtney L Fisher; William F Jackson; Anne M Dorrance Journal: J Hypertens Date: 2022-09-01 Impact factor: 4.776
Authors: Jennifer S Rabin; Jeremy Pruzin; Matthew Scott; Hyun-Sik Yang; Olivia Hampton; Stephanie Hsieh; Aaron P Schultz; Rachel F Buckley; Trey Hedden; Dorene Rentz; Keith A Johnson; Reisa A Sperling; Jasmeer P Chhatwal Journal: Neurology Date: 2022-04-26 Impact factor: 11.800
Authors: Kimberly D Mueller; Derek Norton; Rebecca L Koscik; Martha C Morris; Erin M Jonaitis; Lindsay R Clark; Taylor Fields; Samantha Allison; Sara Berman; Sarah Kraning; Megan Zuelsdorff; Ozioma Okonkwo; Nathaniel Chin; Cynthia M Carlsson; Barbara B Bendlin; Bruce P Hermann; Sterling C Johnson Journal: PLoS One Date: 2020-04-23 Impact factor: 3.240
Authors: Tobey J Betthauser; Rebecca L Koscik; Erin M Jonaitis; Samantha L Allison; Karly A Cody; Claire M Erickson; Howard A Rowley; Charles K Stone; Kimberly D Mueller; Lindsay R Clark; Cynthia M Carlsson; Nathaniel A Chin; Sanjay Asthana; Bradley T Christian; Sterling C Johnson Journal: Brain Date: 2020-01-01 Impact factor: 13.501
Authors: Lezanne Ooi; Mirella Dottori; Anthony L Cook; Martin Engel; Vini Gautam; Alexandra Grubman; Damián Hernández; Anna E King; Simon Maksour; Helena Targa Dias Anastacio; Rachelle Balez; Alice Pébay; Colin Pouton; Michael Valenzuela; Anthony White; Robert Williamson Journal: Neuroscientist Date: 2020-04-13 Impact factor: 7.519
Authors: Rebecca Langhough Koscik; Bruce P Hermann; Samantha Allison; Lindsay R Clark; Erin M Jonaitis; Kimberly D Mueller; Tobey J Betthauser; Bradley T Christian; Lianlian Du; Ozioma Okonkwo; Alex Birdsill; Nathaniel Chin; Carey Gleason; Sterling C Johnson Journal: Front Aging Neurosci Date: 2021-07-26 Impact factor: 5.750