Carmen Rodríguez-Blázquez1, Mario Alvarez2, Tomoko Arakaki3, Víctor Campos Arillo4, Pedro Chaná5, William Fernández6, Nélida Garretto3, Juan Carlos Martínez-Castrillo7, Mayela Rodríguez-Violante8, Marcos Serrano-Dueñas9, Diego Ballesteros10, Jose Manuel Rojo-Abuin11, Kallol Ray Chaudhuri12, Marcelo Merello10, Pablo Martínez-Martín1. 1. National Center of Epidemiology and CIBERNED Carlos III Institute of Health Madrid Spain. 2. Department of Movement Disorders and Neurodegeneration CIREN La Habana Cuba. 3. Department of Neurology Hospital Ramos Mejía Centro Universitario de Neurología de la Universidad de Buenos Aires (UBA) Buenos Aires Argentina. 4. Movement Disorders Unit Department of Neuroscience Hospital Vithas-Xanit International Benalmadena Malaga Spain. 5. CETRAM Facultad de Ciencias Médicas Universidad de Santiago de Chile Santiago Chile. 6. Movement Disorders Unit Department of Neurology Universidad Nacional de Colombia Bogotá Colombia. 7. Movement Disorders Unit Department of Neurology Hospital Ramón y Cajal IRYCIS Madrid Spain. 8. Movement Disorders Unit Instituto Nacional de Neurología y Neurocirugía México DF México. 9. Movement Disorder and Biostatistics Units Neurological Service Carlos Andrade Marín Hospital and Medicine Faculty (Ecuadorian Institute of Social Security) Pontifical Catholic University of Ecuador Quito Ecuador. 10. Movement Disorders Section Raul Carrea Institute for Neurological Research (FLENI) Buenos Aires Argentina. 11. Department of Statistics Centre of Human and Social Sciences Spanish Council for Scientific Research Madrid Spain. 12. National Parkinson Foundation International Centre of Excellence King's College Hospital King's College London.
Abstract
BACKGROUND: Parkinson's disease (PD) is characterized by motor and nonmotor symptoms that progress with time, causing disability. The performance of a disease-specific, self-applied tool for assessing disability, the MDS-UPDRS Part II, is tested against generic and rater-based rating scales. METHODS: An international, cross-sectional, observational study was performed. Patients were assessed with the Hoehn and Yahr (HY) and five disability measures: MDS-UPDRS Part II, Schwab and England Scale (S&E), Clinical Impression of Severity Index-PD (CISI-PD) Disability item, Barthel Index (BI), and Rapid Assessment of Disability Scale (RADS). Data analysis included correlation coefficients, Mann-Whitney and Kruskal-Wallis tests, and intraclass-correlation coefficient for concordance. RESULTS: The sample was composed of 451 patients, 55.2% men, with a mean age of 65.06 years (SD = 10.71). Disability rating scales correlated from |0.75| (CISI-PD Disability with BI) to 0.87 (MDS-UPDRS Part II with RADS). In general, MDS-UPDRS Part II showed high correlation coefficients with clinical variables and satisfactory concordance with the rest of disability measures, with ICC ranging from 0.83 (with BI) to 0.93 (with RADS). All disability rating scales showed statistical significant differences in the sample grouped by sex, age, disease duration, and severity level. CONCLUSIONS: The MDS-UPDRS Part II showed an appropriate performance to assess disability in PD, even better than some rater-based, generic or specific, scales applied in this study.
BACKGROUND: Parkinson's disease (PD) is characterized by motor and nonmotor symptoms that progress with time, causing disability. The performance of a disease-specific, self-applied tool for assessing disability, the MDS-UPDRS Part II, is tested against generic and rater-based rating scales. METHODS: An international, cross-sectional, observational study was performed. Patients were assessed with the Hoehn and Yahr (HY) and five disability measures: MDS-UPDRS Part II, Schwab and England Scale (S&E), Clinical Impression of Severity Index-PD (CISI-PD) Disability item, Barthel Index (BI), and Rapid Assessment of Disability Scale (RADS). Data analysis included correlation coefficients, Mann-Whitney and Kruskal-Wallis tests, and intraclass-correlation coefficient for concordance. RESULTS: The sample was composed of 451 patients, 55.2% men, with a mean age of 65.06 years (SD = 10.71). Disability rating scales correlated from |0.75| (CISI-PD Disability with BI) to 0.87 (MDS-UPDRS Part II with RADS). In general, MDS-UPDRS Part II showed high correlation coefficients with clinical variables and satisfactory concordance with the rest of disability measures, with ICC ranging from 0.83 (with BI) to 0.93 (with RADS). All disability rating scales showed statistical significant differences in the sample grouped by sex, age, disease duration, and severity level. CONCLUSIONS: The MDS-UPDRS Part II showed an appropriate performance to assess disability in PD, even better than some rater-based, generic or specific, scales applied in this study.
Authors: Pablo Martínez-Martín; Julian Benito-León; Fernando Alonso; M José Catalán; Margarita Pondal; Aurelio Tobías; Ivana Zamarbide Journal: Mov Disord Date: 2003-09 Impact factor: 10.338
Authors: Glenn T Stebbins; Christopher G Goetz; David J Burn; Joseph Jankovic; Tien K Khoo; Barbara C Tilley Journal: Mov Disord Date: 2013-02-13 Impact factor: 10.338
Authors: Pablo Martinez-Martin; Carmen Rodriguez-Blazquez; Mario Alvarez-Sanchez; Tomoko Arakaki; Alberto Bergareche-Yarza; Anabel Chade; Nelida Garretto; Oscar Gershanik; Monica M Kurtis; Juan Carlos Martinez-Castrillo; Amelia Mendoza-Rodriguez; Henry P Moore; Mayela Rodriguez-Violante; Carlos Singer; Barbara C Tilley; Jing Huang; Glenn T Stebbins; Christopher G Goetz Journal: J Neurol Date: 2012-08-05 Impact factor: 4.849
Authors: Pablo Martínez-Martín; Julián Benito-León; Fernando Alonso; Maria José Catalán; Margarita Pondal; Ivana Zamarbide Journal: Mov Disord Date: 2004-03 Impact factor: 10.338
Authors: Christopher G Goetz; Barbara C Tilley; Stephanie R Shaftman; Glenn T Stebbins; Stanley Fahn; Pablo Martinez-Martin; Werner Poewe; Cristina Sampaio; Matthew B Stern; Richard Dodel; Bruno Dubois; Robert Holloway; Joseph Jankovic; Jaime Kulisevsky; Anthony E Lang; Andrew Lees; Sue Leurgans; Peter A LeWitt; David Nyenhuis; C Warren Olanow; Olivier Rascol; Anette Schrag; Jeanne A Teresi; Jacobus J van Hilten; Nancy LaPelle Journal: Mov Disord Date: 2008-11-15 Impact factor: 10.338