Literature DB >> 3036316

The effect of the imidazodiazepine Ro 15-4513 on the anticonvulsant effects of diazepam, sodium pentobarbital and ethanol.

D J Nutt, R G Lister.   

Abstract

The ability of the imidazodiazepine Ro 15-4513 to antagonize the anticonvulsant effects of diazepam, sodium pentobarbital and ethanol was investigated. Ro 15-4513 alone significantly lowered seizure threshold to bicuculline and this effect subtracted from the anticonvulsant effects of sodium pentobarbital and ethanol. In contrast, Ro 15-4513 completely reversed the anticonvulsant effects of diazepam, consistent with suggestions that it is a competitive ligand for benzodiazepine receptors.

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Year:  1987        PMID： 3036316     DOI： 10.1016/0006-8993(87)90170-3

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  6 in total

Review 1.  GABAergic mechanisms in the electrophysiological actions of ethanol on cerebellar neurons.

Authors:  M R Palmer; B J Hoffer
Journal:  Neurochem Res       Date:  1990-02       Impact factor: 3.996

Review 2.  Ethanol and the benzodiazepine-GABA receptor-ionophore complex.

Authors:  M K Ticku
Journal:  Experientia       Date:  1989-05-15

3.  Investigation of the involvement of opioid receptors in the action of anticonvulsants.

Authors:  H C Jackson; D J Nutt
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

4.  Mechanistic and functional divergence between thyrotropin-releasing hormone and RO 15-4513 interactions with ethanol.

Authors:  T J McCown; G R Breese
Journal:  Alcohol Clin Exp Res       Date:  1989-10       Impact factor: 3.455

5.  Ro 15-4513 selectively attenuates ethanol, but not sucrose, reinforced responding in a concurrent access procedure; comparison to other drugs.

Authors:  N M Petry
Journal:  Psychopharmacology (Berl)       Date:  1995-09       Impact factor: 4.530

6.  Zolpidem generalization and antagonism in male and female cynomolgus monkeys trained to discriminate 1.0 or 2.0 g/kg ethanol.

Authors:  Christa M Helms; Laura S M Rogers; Courtney A Waters; Kathleen A Grant
Journal:  Alcohol Clin Exp Res       Date:  2008-07       Impact factor: 3.455
  6 in total

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