Literature DB >> 2542081

Ethanol and the benzodiazepine-GABA receptor-ionophore complex.

M K Ticku1.   

Abstract

Ethanol has a pharmacological profile similar to that of classes of drugs like benzodiazepines and barbiturates, which enhance GABAergic transmission in the mammalian CNS. Several lines of behavioral, electrophysiological and biochemical studies suggest that ethanol may bring about most of its effects by enhancing GABAergic transmission. Recently, ethanol at relevant pharmacological concentrations has been shown to enhance GABA-induced 36Cl-fluxes in cultured spinal cord neurons, synaptoneurosomes and microsacs. These enhancing effects of ethanol were blocked by GABA antagonists. Ro15-4513, an azido analogue of classical BZ antagonist Ro15-1788, reversed most of the behavioral effects of ethanol and other effects involving 36Cl-flux studies. The studies summarized below indicate that most of the pharmacological effects of ethanol can be related to its effects on GABAergic transmission.

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Year:  1989        PMID： 2542081     DOI： 10.1007/bf01952022

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  54 in total

1.  Alcohol and presynaptic inhibition in an isolated spinal cord preparation.

Authors:  R A Davidoff
Journal:  Arch Neurol       Date:  1973-01

2.  Potentiation of cutaneous inhibition by alcohol.

Authors:  N R Banna
Journal:  Experientia       Date:  1969-06-15

Review 3.  The effect of ethanol on GABAergic transmission.

Authors:  W A Hunt
Journal:  Neurosci Biobehav Rev       Date:  1983       Impact factor: 8.989

4.  Interactions of the imidazodiazepine Ro 15-4513 with chemical convulsants.

Authors:  R G Lister; D J Nutt
Journal:  Br J Pharmacol       Date:  1988-01       Impact factor: 8.739

5.  Effects of GABAergic agonists and antagonists on various ethanol-induced behavioral changes.

Authors:  S Liljequist; J Engel
Journal:  Psychopharmacology (Berl)       Date:  1982       Impact factor: 4.530

6.  Involvement of a GABAergic mechanism in the anticonvulsant effect of pentobarbital against maximal electroshock-induced seizures in rats.

Authors:  S K Rastogi; M K Ticku
Journal:  Pharmacol Biochem Behav       Date:  1985-01       Impact factor: 3.533

7.  Low doses of ethanol inhibit the firing of neurons in the substantia nigra, pars reticulata: a GABAergic effect?

Authors:  G Mereu; G L Gessa
Journal:  Brain Res       Date:  1985-12-23       Impact factor: 3.252

8.  RO 15-4513 induces seizures in DBA/2 mice undergoing alcohol withdrawal.

Authors:  R G Lister; J W Karanian
Journal:  Alcohol       Date:  1987 Sep-Oct       Impact factor: 2.405

9.  Ethanol specifically potentiates GABA-mediated neurotransmission in feline cerebral cortex.

Authors:  J N Nestoros
Journal:  Science       Date:  1980-08-08       Impact factor: 47.728

10.  Ethanol enhances GABA-induced 36Cl-influx in primary spinal cord cultured neurons.

Authors:  M K Ticku; P Lowrimore; P Lehoullier
Journal:  Brain Res Bull       Date:  1986-07       Impact factor: 4.077
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  10 in total

1.  Basis of the gabamimetic profile of ethanol.

Authors:  G R Breese; H E Criswell; M Carta; P D Dodson; H J Hanchar; R T Khisti; M Mameli; Z Ming; A L Morrow; R W Olsen; T S Otis; L H Parsons; S N Penland; M Roberto; G R Siggins; C F Valenzuela; M Wallner
Journal:  Alcohol Clin Exp Res       Date:  2006-04       Impact factor: 3.455

2.  A comparison of the effect of lorazepam on memory in heavy and low social drinkers.

Authors:  J M Nichols; F Martin; K C Kirkby
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

3.  Effects of alcohols on responses evoked by inositol trisphosphate in Xenopus oocytes.

Authors:  V Ilyin; I Parker
Journal:  J Physiol       Date:  1992-03       Impact factor: 5.182

Review 4.  The neurobiology of alcohol consumption and alcoholism: an integrative history.

Authors:  Boris Tabakoff; Paula L Hoffman
Journal:  Pharmacol Biochem Behav       Date:  2013-10-17       Impact factor: 3.533

Review 5.  A new meaning for "Gin & Tonic": tonic inhibition as the target for ethanol action in the brain.

Authors:  Istvan Mody; Joseph Glykys; Weizheng Wei
Journal:  Alcohol       Date:  2007-05-23       Impact factor: 2.405

6.  Use of 82Br- radiotracer to study transmembrane halide flux: the effect of a tranquilizing drug, chlordiazepoxide on channel opening of a GABAA receptor.

Authors:  D J Cash; P Serfözö; K Zinn
Journal:  J Membr Biol       Date:  1995-06       Impact factor: 1.843

7.  Alcohol inhibits morphine/cocaine reward memory acquisition and reconsolidation in rats.

Authors:  Shimin Zhu; Pingping Chen; Mingzhu Chen; Jiawei Ruan; Wanying Ren; Xinyu Zhang; Yang Gao; Yanqin Li
Journal:  Psychopharmacology (Berl)       Date:  2020-01-07       Impact factor: 4.530

8.  Tyrosine kinase phosphorylation of GABA(A) receptor alpha1, beta2 and gamma2 subunits following chronic intermittent ethanol (CIE) exposure of cultured cortical neurons of mice.

Authors:  C R Marutha Ravindran; Maharaj K Ticku
Journal:  Neurochem Res       Date:  2006-08-22       Impact factor: 4.414

9.  Missense Gamma-Aminobutyric Acid Receptor Polymorphisms Are Associated with Reaction Time, Motor Time, and Ethanol Effects in Vivo.

Authors:  Elena García-Martín; María I Ramos; José A Cornejo-García; Segismundo Galván; James R Perkins; Laura Rodríguez-Santos; Hortensia Alonso-Navarro; Félix J Jiménez-Jiménez; José A G Agúndez
Journal:  Front Cell Neurosci       Date:  2018-01-31       Impact factor: 5.505

Review 10.  Potentiation of Gamma Aminobutyric Acid Receptors (GABAAR) by Ethanol: How Are Inhibitory Receptors Affected?

Authors:  Benjamin Förstera; Patricio A Castro; Gustavo Moraga-Cid; Luis G Aguayo
Journal:  Front Cell Neurosci       Date:  2016-05-06       Impact factor: 5.505
  10 in total

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