Literature DB >> 30362094

NANOG-Dependent Metabolic Reprogramming and Symmetric Division in Tumor-Initiating Stem-like Cells.

Keigo Machida1,2.   

Abstract

Alcohol abuse synergistically heightens the development of the third most deadliest cancer hepatocellular carcinoma (HCC) in patients infected with hepatitis C virus (HCV). Ectopically expressed TLR4 promotes liver tumorigenesis in alcohol-fed HCV Ns5a or Core transgenic mice. CD133+/CD49f + tumor-initiating stem cell-like cells (TICs) isolated from these models are tumorigenic have p53 degradation via phosphorylation of the protective protein NUMB and its dissociation from p53 by the oncoprotein TBC1D15. Nutrient deprivation reduces overexpressed TBC1D15 in TICs via autophagy-mediated degradation, suggesting a possible role of this oncoprotein in linking metabolic reprogramming and self-renewal.

Entities:  

Keywords:  Cancer stem cells; HCC; NUMB; Tumor-intiating stem-like cells (TICs)

Mesh：

Substances：

Year:  2018        PMID： 30362094      PMCID： PMC6687510          DOI： 10.1007/978-3-319-98788-0_8

Source DB:  PubMed          Journal:  Adv Exp Med Biol        ISSN： 0065-2598            Impact factor:   2.622


  48 in total

Review 1.  Stem cells, cancer, and cancer stem cells.

Authors:  T Reya; S J Morrison; M F Clarke; I L Weissman
Journal:  Nature       Date:  2001-11-01       Impact factor: 49.962

2.  Hepatitis C virus core protein inhibits microsomal triglyceride transfer protein activity and very low density lipoprotein secretion: a model of viral-related steatosis.

Authors:  Gabriel Perlemuter; Abdelmajid Sabile; Philippe Letteron; Giovanna Vona; André Topilco; Yves Chrétien; Kazuhiko Koike; Dominique Pessayre; John Chapman; Giovanna Barba; Christian Bréchot
Journal:  FASEB J       Date:  2002-02       Impact factor: 5.191

3.  Hepatitis C virus down-regulates insulin receptor substrates 1 and 2 through up-regulation of suppressor of cytokine signaling 3.

Authors:  Takumi Kawaguchi; Takafumi Yoshida; Masaru Harada; Takao Hisamoto; Yumiko Nagao; Tatsuya Ide; Eitaro Taniguchi; Hiroto Kumemura; Shinichiro Hanada; Michiko Maeyama; Shinji Baba; Hironori Koga; Ryukichi Kumashiro; Takato Ueno; Hisanobu Ogata; Akihiko Yoshimura; Michio Sata
Journal:  Am J Pathol       Date:  2004-11       Impact factor: 4.307

Review 4.  Hepatocellular carcinoma.

Authors:  K Okuda
Journal:  J Hepatol       Date:  2000       Impact factor: 25.083

5.  Oxidative stress in the absence of inflammation in a mouse model for hepatitis C virus-associated hepatocarcinogenesis.

Authors:  K Moriya; K Nakagawa; T Santa; Y Shintani; H Fujie; H Miyoshi; T Tsutsumi; T Miyazawa; K Ishibashi; T Horie; K Imai; T Todoroki; S Kimura; K Koike
Journal:  Cancer Res       Date:  2001-06-01       Impact factor: 12.701

6.  Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein.

Authors:  Michiari Okuda; Kui Li; Michael R Beard; Lori A Showalter; Frank Scholle; Stanley M Lemon; Steven A Weinman
Journal:  Gastroenterology       Date:  2002-02       Impact factor: 22.682

7.  Synergism of alcohol, diabetes, and viral hepatitis on the risk of hepatocellular carcinoma in blacks and whites in the U.S.

Authors:  Jian-Min Yuan; Sugantha Govindarajan; Kazuko Arakawa; Mimi C Yu
Journal:  Cancer       Date:  2004-09-01       Impact factor: 6.860

Review 8.  Stem cells and cancer; the polycomb connection.

Authors:  Merel E Valk-Lingbeek; Sophia W M Bruggeman; Maarten van Lohuizen
Journal:  Cell       Date:  2004-08-20       Impact factor: 41.582

Review 9.  Self-renewal of teratocarcinoma and embryonic stem cells.

Authors:  Ian Chambers; Austin Smith
Journal:  Oncogene       Date:  2004-09-20       Impact factor: 9.867

Review 10.  Hepatitis C and hepatocellular carcinoma.

Authors:  F Yao; N Terrault
Journal:  Curr Treat Options Oncol       Date:  2001-12
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  2 in total

1.  DNMT and EZH2 inhibitors synergize to activate therapeutic targets in hepatocellular carcinoma.

Authors:  Lian Zhang; Hong-Tao Li; Rachel Shereda; Qianjin Lu; Daniel J Weisenberger; Casey O'Connell; Keigo Machida; Woojin An; Heinz-Josef Lenz; Anthony El-Khoueiry; Peter A Jones; Minmin Liu; Gangning Liang
Journal:  Cancer Lett       Date:  2022-09-08       Impact factor: 9.756

2.  Qingyihuaji formula reverses gemcitabine resistant human pancreatic cancer through regulate lncRNA AB209630/miR-373/EphB2-NANOG signals.

Authors:  Peng Chen; Meiying Wang; Cuiping Wang
Journal:  Biosci Rep       Date:  2019-06-18       Impact factor: 3.840
  2 in total

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