Literature DB >> 30359604

Building Models of Brain Disorders with Three-Dimensional Organoids.

Neal D Amin1, Sergiu P Paşca2.   

Abstract

Disorders of the nervous system are challenging to study and treat due to the relative inaccessibility of functional human brain tissue for research. Stem cell-derived 3D human brain organoids have the potential to recapitulate features of the human brain with greater complexity than 2D models and are increasingly being applied to model diseases affecting the central nervous system. Here, we review the use of human brain organoids to investigate neurological and psychiatric (neuropsychiatric) disorders and how this technology may ultimately advance our biological understanding of these conditions.
Copyright © 2018 Elsevier Inc. All rights reserved.

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Year:  2018        PMID： 30359604     DOI： 10.1016/j.neuron.2018.10.007

Source DB:  PubMed          Journal:  Neuron        ISSN： 0896-6273            Impact factor:   17.173


  81 in total

1.  OLIG2 Drives Abnormal Neurodevelopmental Phenotypes in Human iPSC-Based Organoid and Chimeric Mouse Models of Down Syndrome.

Authors:  Ranjie Xu; Andrew T Brawner; Shenglan Li; Jing-Jing Liu; Hyosung Kim; Haipeng Xue; Zhiping P Pang; Woo-Yang Kim; Ronald P Hart; Ying Liu; Peng Jiang
Journal:  Cell Stem Cell       Date:  2019-05-23       Impact factor: 24.633

Review 2.  Integration of CRISPR-engineering and hiPSC-based models of psychiatric genomics.

Authors:  Marliette R Matos; Seok-Man Ho; Nadine Schrode; Kristen J Brennand
Journal:  Mol Cell Neurosci       Date:  2020-07-23       Impact factor: 4.314

Review 3.  Extracellular matrix dynamics in cell migration, invasion and tissue morphogenesis.

Authors:  Kenneth M Yamada; Joshua W Collins; David A Cruz Walma; Andrew D Doyle; Shaimar Gonzalez Morales; Jiaoyang Lu; Kazue Matsumoto; Shayan S Nazari; Rei Sekiguchi; Yoshinari Shinsato; Shaohe Wang
Journal:  Int J Exp Pathol       Date:  2019-06-10       Impact factor: 1.925

Review 4.  Using induced pluripotent stem cell neuronal models to study neurodegenerative diseases.

Authors:  Xinwen Zhang; Di Hu; Yutong Shang; Xin Qi
Journal:  Biochim Biophys Acta Mol Basis Dis       Date:  2019-03-18       Impact factor: 5.187

5.  DSCAM/PAK1 pathway suppression reverses neurogenesis deficits in iPSC-derived cerebral organoids from patients with Down syndrome.

Authors:  Xiao-Yan Tang; Lei Xu; Jingshen Wang; Yuan Hong; Yuanyuan Wang; Qian Zhu; Da Wang; Xin-Yue Zhang; Chun-Yue Liu; Kai-Heng Fang; Xiao Han; Shihua Wang; Xin Wang; Min Xu; Anita Bhattacharyya; Xing Guo; Mingyan Lin; Yan Liu
Journal:  J Clin Invest       Date:  2021-06-15       Impact factor: 14.808

Review 6.  Integrating CRISPR Engineering and hiPSC-Derived 2D Disease Modeling Systems.

Authors:  Kristina Rehbach; Michael B Fernando; Kristen J Brennand
Journal:  J Neurosci       Date:  2020-02-05       Impact factor: 6.167

Review 7.  Using human induced pluripotent stem cells (hiPSCs) to investigate the mechanisms by which Apolipoprotein E (APOE) contributes to Alzheimer's disease (AD) risk.

Authors:  Sreedevi Raman; Nicholas Brookhouser; David A Brafman
Journal:  Neurobiol Dis       Date:  2020-02-05       Impact factor: 5.996

8.  Modeling Controlled Cortical Impact Injury in 3D Brain-Like Tissue Cultures.

Authors:  Volha Liaudanskaya; Joon Yong Chung; Craig Mizzoni; Nicolas Rouleau; Alexander N Berk; Limin Wu; Julia A Turner; Irene Georgakoudi; Michael J Whalen; Thomas J F Nieland; David L Kaplan
Journal:  Adv Healthc Mater       Date:  2020-05-13       Impact factor: 9.933

9.  Pluripotent Stem Cells for Cell Therapy.

Authors:  Insa S Schroeder
Journal:  Methods Mol Biol       Date:  2021

Review 10.  Human organoids to model the developing human neocortex in health and disease.

Authors:  Shokoufeh Khakipoor; Elizabeth E Crouch; Simone Mayer
Journal:  Brain Res       Date:  2020-03-30       Impact factor: 3.252
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