Tong Wang1, Yili Wu1, Weilong Li2, Suyun Li1, Yanping Sun3, Shuxia Li4, Dongfeng Zhang1, Qihua Tan2,4. 1. Department of Epidemiology and Health Statistics, Public Health College, Qingdao University, Qingdao, Shandong, China. 2. Epidemiology and Biostatistics, Department of Public Health, University of Southern Denmark, Odense C, Denmark. 3. Department of Neurology, Affiliated Hospital of Qingdao University, Qingdao, Shandong, China. 4. Unit of Human Genetics, Department of Clinical Research, University of Southern Denmark, Odense C, Denmark.
Abstract
OBJECTIVES: To estimate the effects of baseline grip strength and cognition on the trajectory of functional limitation over time. DESIGN: Longitudinal study of older adults participating in the Survey of Health, Ageing and Retirement in Europe (SHARE). SETTING: Urban and rural households in 11 European countries and Israel. PARTICIPANTS: Individuals aged 50 and older from SHARE (2004-2015) (N=14,073; 52.5% female). MEASUREMENTS: Outcomes were functional limitation scores from five panel wave. Main exposure variables were grip strength and cognitive measures including memory, verbal fluency, and numeracy at baseline. Basic demographic characteristics, life habits, and health status were considered as potential confounders. Mixed-effect linear regression models were fitted. RESULTS: Functional limitation increased significantly over time (follow-up range 0.9-11.6 years) (β = 0.051, P < .001). Mixed-effect linear regression models identified significant interactions between grip strength (β = -0.001, P < .001), numeracy (β = -0.012, P < .001), verbal fluency (β = -0.003, P < .001), word recall (β = -0.006, P < .001) and time on functional limitation. CONCLUSION: Stronger baseline grip strength and better cognition predicted a slower rate of increase in functional limitation over time in older adults. Grip strength and cognitive function appeared to be useful indicators of the functional limitation process and attested to their value in monitoring functional change in European older adults. J Am Geriatr Soc 67:93-99, 2019.
OBJECTIVES: To estimate the effects of baseline grip strength and cognition on the trajectory of functional limitation over time. DESIGN: Longitudinal study of older adults participating in the Survey of Health, Ageing and Retirement in Europe (SHARE). SETTING: Urban and rural households in 11 European countries and Israel. PARTICIPANTS: Individuals aged 50 and older from SHARE (2004-2015) (N=14,073; 52.5% female). MEASUREMENTS: Outcomes were functional limitation scores from five panel wave. Main exposure variables were grip strength and cognitive measures including memory, verbal fluency, and numeracy at baseline. Basic demographic characteristics, life habits, and health status were considered as potential confounders. Mixed-effect linear regression models were fitted. RESULTS: Functional limitation increased significantly over time (follow-up range 0.9-11.6 years) (β = 0.051, P < .001). Mixed-effect linear regression models identified significant interactions between grip strength (β = -0.001, P < .001), numeracy (β = -0.012, P < .001), verbal fluency (β = -0.003, P < .001), word recall (β = -0.006, P < .001) and time on functional limitation. CONCLUSION: Stronger baseline grip strength and better cognition predicted a slower rate of increase in functional limitation over time in older adults. Grip strength and cognitive function appeared to be useful indicators of the functional limitation process and attested to their value in monitoring functional change in European older adults. J Am Geriatr Soc 67:93-99, 2019.
Authors: Suzanne G Orchard; Galina Polekhina; Joanne Ryan; Raj C Shah; Elsdon Storey; Trevor T-J Chong; Jessica E Lockery; Stephanie A Ward; Rory Wolfe; Mark R Nelson; Christopher M Reid; Anne M Murray; Sara E Espinoza; Anne B Newman; John J McNeil; Taya A Collyer; Michele L Callisaya; Robyn L Woods Journal: Alzheimers Dement (Amst) Date: 2022-09-22