Chan-Wei Nien1,2, Chia-Yi Lee2,3, Shih-Chun Chao2,4,5, Hung-Jui Hsu1,2, Jing-Yang Huang6, Chao-Bin Yeh7,8, Hung-Chi Chen9,10,11, Chi-Chin Sun12,13, Hung-Yu Lin1,2,14,15,16, Shun-Fa Yang1,6. 1. Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan. 2. Department of Ophthalmology, Show Chwan Memorial Hospital, Changhua, Taiwan. 3. Department of Optometry, College of Medicine and Life Science, Chung Hwa University of Medical Technology, Tainan, Taiwan. 4. Department of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu, Taiwan. 5. Department of Optometry, Central Taiwan University of Science and Technology, Taichung, Taiwan. 6. Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan. 7. Department of Emergency Medicine, School of Medicine, Chung Shan Medical University, Taichung, Taiwan. 8. Department of Emergency Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan. 9. Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Taiwan. 10. Department of Medicine, Chang Gung University College of Medicine, Taoyuan, Taiwan. 11. Center for Tissue Engineering, Chang Gung Memorial Hospital, Linkou, Taiwan. 12. Department of Ophthalmology, Chang Gung Memorial Hospital, Keelung, Taiwan. 13. Department of Chinese Medicine, Chang Gung University, Taoyuan City, Taiwan. 14. Department of Optometry, Chung Shan Medical University, Taichung, Taiwan. 15. Department of Optometry, Yuanpei University of Medical Technology, Hsinchu, Taiwan. 16. Department of Exercise and Health Promotion, Chung Chou University of Science and Technology, Changhua, Taiwan.
Abstract
Purpose: The purpose of this study was to evaluate the effect of uveitis on the development of various keratopathies via the use of the National Health Insurance Research Database (NHIRD) in Taiwan. Methods: Approximately 1 million patients were randomly sampled from the registry of the NHIRD. Patients diagnosed with uveitis by ophthalmologists were enrolled in the study group after exclusion. Each individual in the study group was age and sex matched to four non-uveitis individuals who serve as the control group. In addition to keratopathy, other possible risk factors and medications were included in the multivariate model, and the effects of different subtypes of uveitis for developing keratopathies were also analyzed. Results: A total of 4773 uveitis patients (2662 male and 2111 female) and 19,092 non-uveitis patients (10,648 male and 8444 female) were enrolled. There were 406 events of keratopathy in the study group, and another 764 events occurred in the control group. A higher incidence rate was found in the study group after adjustment (adjusted hazard ratio [aHR]: 1.772), with a greater cumulative probability (P < 0.0001). For the subgroup analysis, anterior uveitis (aHR = 1.765) and panuveitis (aHR = 3.386) increased the risk of developing keratopathies. Moreover, male sex was associated with a higher aHR than female sex for developing keratopathies in the study group. Conclusions: The presence of uveitis significantly elevates the risk for developing keratopathy.
Purpose: The purpose of this study was to evaluate the effect of uveitis on the development of various keratopathies via the use of the National Health Insurance Research Database (NHIRD) in Taiwan. Methods: Approximately 1 million patients were randomly sampled from the registry of the NHIRD. Patients diagnosed with uveitis by ophthalmologists were enrolled in the study group after exclusion. Each individual in the study group was age and sex matched to four non-uveitis individuals who serve as the control group. In addition to keratopathy, other possible risk factors and medications were included in the multivariate model, and the effects of different subtypes of uveitis for developing keratopathies were also analyzed. Results: A total of 4773 uveitispatients (2662 male and 2111 female) and 19,092 non-uveitispatients (10,648 male and 8444 female) were enrolled. There were 406 events of keratopathy in the study group, and another 764 events occurred in the control group. A higher incidence rate was found in the study group after adjustment (adjusted hazard ratio [aHR]: 1.772), with a greater cumulative probability (P < 0.0001). For the subgroup analysis, anterior uveitis (aHR = 1.765) and panuveitis (aHR = 3.386) increased the risk of developing keratopathies. Moreover, male sex was associated with a higher aHR than female sex for developing keratopathies in the study group. Conclusions: The presence of uveitis significantly elevates the risk for developing keratopathy.