Tzu-Chen Lo1,2, Yu-Yen Chen3,4,5,6, Hsin-Hua Chen2,7,8,9,10,11. 1. Department of Medical Education, Taichung Veterans General Hospital, Taichung, 407, Taiwan. 2. School of Medicine, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan. 3. School of Medicine, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan. yuyenchen.phd@gmail.com. 4. Department of Ophthalmology, Taichung Veterans General Hospital, Taichung, 407, Taiwan. yuyenchen.phd@gmail.com. 5. Institute of Public Health and Community Medicine Research Center, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan. yuyenchen.phd@gmail.com. 6. School of Medicine, Chung Shan Medical University, Taichung, 402, Taiwan. yuyenchen.phd@gmail.com. 7. Institute of Public Health and Community Medicine Research Center, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan. 8. School of Medicine, Chung Shan Medical University, Taichung, 402, Taiwan. 9. Department of Industrial Engineering and Enterprise Information, Tunghai University, Taichung, 407, Taiwan. 10. Division of Allergy, Immunology, and Rheumatology & Division of General Internal Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, 407, Taiwan. 11. Institute of Biomedical Science and Rong-Hsing Research Center for Translational Medicine, Chung-Hsing University, Taichung, 402, Taiwan.
Abstract
OBJECTIVES: To investigate the potential association between uveitis and an increased risk of developing inflammatory bowel disease (IBD). METHODS: We conducted a retrospective cohort study by interrogating data from the Taiwan National Health Insurance Research Database entered between January 1, 2001 and December 31, 2013 to identify uveitis patients and age- and gender-matched controls. The cumulative incidence rates of subsequent IBD in the two groups were compared. The adjusted hazard ratio (HR) of IBD related to uveitis was generated by a multivariate cox regression model after adjustment for hypertension, diabetes, hyperlipidaemia, obesity and smoking. Furthermore, the HRs of the Crohn's disease (CD) and ulcerative colitis (UC) IBD subtypes were calculated separately. RESULTS: A total of 198,923 subjects with uveitis and 397,846 controls were enroled. The mean age of the cohort was 47.7 ± 18.9 years. A significantly higher cumulative incidence of IBD was found in the uveitis group than in controls (4.13% vs. 1.48%, p < 0.0001). Under univariate cox regression analysis, uveitis patients had a significantly higher risk of IBD (HR = 1.47; 95% confidence interval (CI): 1.43-1.52, p < 0.0001). The association remained significant in the multivariate regression model, with an adjusted HR of 1.44 (95% CI: 1.39-1.49, p < 0.0001). Moreover, in subgroup analysis, uveitis was significantly associated with an increased risk of Crohn's disease (adjusted HR = 1.49; 95% CI: 1.44-1.54), but not with ulcerative colitis (adjusted HR = 1.03; 95% CI: 0.92-1.15). CONCLUSIONS: Patients with uveitis are at significantly greater risk of developing IBD than individuals without uveitis.
OBJECTIVES: To investigate the potential association between uveitis and an increased risk of developing inflammatory bowel disease (IBD). METHODS: We conducted a retrospective cohort study by interrogating data from the Taiwan National Health Insurance Research Database entered between January 1, 2001 and December 31, 2013 to identify uveitis patients and age- and gender-matched controls. The cumulative incidence rates of subsequent IBD in the two groups were compared. The adjusted hazard ratio (HR) of IBD related to uveitis was generated by a multivariate cox regression model after adjustment for hypertension, diabetes, hyperlipidaemia, obesity and smoking. Furthermore, the HRs of the Crohn's disease (CD) and ulcerative colitis (UC) IBD subtypes were calculated separately. RESULTS: A total of 198,923 subjects with uveitis and 397,846 controls were enroled. The mean age of the cohort was 47.7 ± 18.9 years. A significantly higher cumulative incidence of IBD was found in the uveitis group than in controls (4.13% vs. 1.48%, p < 0.0001). Under univariate cox regression analysis, uveitis patients had a significantly higher risk of IBD (HR = 1.47; 95% confidence interval (CI): 1.43-1.52, p < 0.0001). The association remained significant in the multivariate regression model, with an adjusted HR of 1.44 (95% CI: 1.39-1.49, p < 0.0001). Moreover, in subgroup analysis, uveitis was significantly associated with an increased risk of Crohn's disease (adjusted HR = 1.49; 95% CI: 1.44-1.54), but not with ulcerative colitis (adjusted HR = 1.03; 95% CI: 0.92-1.15). CONCLUSIONS: Patients with uveitis are at significantly greater risk of developing IBD than individuals without uveitis.
Authors: Carmen Stolwijk; Astrid van Tubergen; José Dionisio Castillo-Ortiz; Annelies Boonen Journal: Ann Rheum Dis Date: 2013-09-02 Impact factor: 19.103
Authors: Brenton G Yuen; Vivien M Tham; Erica N Browne; Rachel Weinrib; Durga S Borkar; John V Parker; Aileen Uchida; Aleli C Vinoya; Nisha R Acharya Journal: Ophthalmology Date: 2015-03-30 Impact factor: 12.079
Authors: Henry Roberts; Shesh N Rai; Jianmin Pan; J Michael Rao; Robert C Keskey; Ziad Kanaan; Ethan P Short; Edward Mottern; Susan Galandiuk Journal: Digestion Date: 2014-10-01 Impact factor: 3.216
Authors: Peiqi Wang; Jun Hu; Shadi Ghadermarzi; Ali Raza; Douglas O'Connell; Amy Xiao; Faraz Ayyaz; Min Zhi; Yuanqi Zhang; Nimisha K Parekh; Mark Lazarev; Alyssa Parian; Steven R Brant; Marshall Bedine; Brindusa Truta; Pinjin Hu; Rupa Banerjee; Susan M Hutfless Journal: Dig Dis Sci Date: 2018-06-04 Impact factor: 3.199
Authors: Luc Biedermann; Laura Renz; Nicolas Fournier; Jean-Benoît Rossel; Matthias Butter; Sena Bluemel; Stephan R Vavricka; Gerhard Rogler; Michael Scharl Journal: Therap Adv Gastroenterol Date: 2019-08-13 Impact factor: 4.409
Authors: Melanie Craven; Charlotte E Egan; Scot E Dowd; Sean P McDonough; Belgin Dogan; Eric Y Denkers; Dwight Bowman; Ellen J Scherl; Kenneth W Simpson Journal: PLoS One Date: 2012-07-25 Impact factor: 3.240