Literature DB >> 3034916

Alpha-actinin-containing aggregates in transformed cells are highly dynamic structures.

S K Stickel, Y L Wang.   

Abstract

Normal rat kidney cells infected with a Rous sarcoma virus (strain LA23) were used to study the dynamics of alpha-actinin-containing aggregates in transformed cells. Experiments were performed by microinjecting living cells with iodoacetamidotetramethylrhodamine alpha-actinin and allowing the fluorescent analogue to incorporate into cellular structures. Subsequent time-lapse recording indicated that the alpha-actinin-containing aggregates can undergo rapid formation, movement, and breakdown. In addition, experiments using the photobleaching recovery technique indicated that alpha-actinin molecules associated with the aggregates have a very high rate of exchange, whereas those associated with adhesion plaques in normal cells exchange much more slowly. The dynamic properties of alpha-actinin-containing aggregates may be closely related to the changes in cellular behavior upon oncogenic transformation.

Entities:  

Mesh：

Substances：

Year:  1987        PMID： 3034916      PMCID： PMC2114522          DOI： 10.1083/jcb.104.6.1521

Source DB:  PubMed          Journal:  J Cell Biol        ISSN： 0021-9525            Impact factor:   10.539


  18 in total

1.  Changes in microfilament organization and surface topogrophy upon transformation of chick embryo fibroblasts with Rous sarcoma virus.

Authors:  E Wang; A R Goldberg
Journal:  Proc Natl Acad Sci U S A       Date:  1976-11       Impact factor: 11.205

2.  A 130K protein from chicken gizzard: its localization at the termini of microfilament bundles in cultured chicken cells.

Authors:  B Geiger
Journal:  Cell       Date:  1979-09       Impact factor: 41.582

3.  F-actin aggregates may activate transformed cell surfaces.

Authors:  W W Carley; W W Webb
Journal:  Cell Motil       Date:  1983

4.  Altered distributions of the cytoskeletal proteins vinculin and alpha-actinin in cultured fibroblasts transformed by Rous sarcoma virus.

Authors:  T David-Pfeuty; S J Singer
Journal:  Proc Natl Acad Sci U S A       Date:  1980-11       Impact factor: 11.205

5.  Talin: a cytoskeletal component concentrated in adhesion plaques and other sites of actin-membrane interaction.

Authors:  K Burridge; L Connell
Journal:  Cell Motil       Date:  1983

6.  Microinjection of early SV40 DNA fragments and T antigen.

Authors:  A Graessmann; M Graessmann; C Mueller
Journal:  Methods Enzymol       Date:  1980       Impact factor: 1.600

7.  Microinjection and localization of a 130K protein in living fibroblasts: a relationship to actin and fibronectin.

Authors:  K Burridge; J R Feramisco
Journal:  Cell       Date:  1980-03       Impact factor: 41.582

8.  Measurement of the lateral mobility of cell surface components in single, living cells by fluorescence recovery after photobleaching.

Authors:  K Jacobson; Z Derzko; E S Wu; Y Hou; G Poste
Journal:  J Supramol Struct       Date:  1976

9.  Formation of cell-to-substrate contacts during fibroblast motility: an interference-reflexion study.

Authors:  C S Izzard; L R Lochner
Journal:  J Cell Sci       Date:  1980-04       Impact factor: 5.285

10.  F-actin aggregates in transformed cells.

Authors:  W W Carley; L S Barak; W W Webb
Journal:  J Cell Biol       Date:  1981-09       Impact factor: 10.539
View more
  16 in total

1.  Dynamin forms a Src kinase-sensitive complex with Cbl and regulates podosomes and osteoclast activity.

Authors:  Angela Bruzzaniti; Lynn Neff; Archana Sanjay; William C Horne; Pietro De Camilli; Roland Baron
Journal:  Mol Biol Cell       Date:  2005-05-04       Impact factor: 4.138

2.  Cellular partitioning of beta-1 integrins and their phosphorylated forms is altered after transformation by Rous sarcoma virus or treatment with cytochalasin D.

Authors:  B Haimovich; B J Aneskievich; D Boettiger
Journal:  Cell Regul       Date:  1991-04

3.  Cell locomotion and focal adhesions are regulated by substrate flexibility.

Authors:  R J Pelham; Y l Wang
Journal:  Proc Natl Acad Sci U S A       Date:  1997-12-09       Impact factor: 11.205

Review 4.  The structure and function of alpha-actinin.

Authors:  A Blanchard; V Ohanian; D Critchley
Journal:  J Muscle Res Cell Motil       Date:  1989-08       Impact factor: 2.698

5.  Biochemical localization of the transformation-sensitive 52 kDa (p52) protein to the substratum contact regions of cultured rat fibroblasts. Butyrate induction, characterization, and quantification of p52 in v-ras transformed cells.

Authors:  P J Higgins; M P Ryan
Journal:  Biochem J       Date:  1989-01-01       Impact factor: 3.857

6.  Wiskott-Aldrich syndrome protein regulates podosomes in primary human macrophages.

Authors:  S Linder; D Nelson; M Weiss; M Aepfelbacher
Journal:  Proc Natl Acad Sci U S A       Date:  1999-08-17       Impact factor: 11.205

7.  Dynamin reduces Pyk2 Y402 phosphorylation and SRC binding in osteoclasts.

Authors:  Angela Bruzzaniti; Lynn Neff; Amanda Sandoval; Liping Du; William C Horne; Roland Baron
Journal:  Mol Cell Biol       Date:  2009-04-20       Impact factor: 4.272

Review 8.  PtdIns(3,4)P2 instigates focal adhesions to generate podosomes.

Authors:  Tsukasa Oikawa; Tadaomi Takenawa
Journal:  Cell Adh Migr       Date:  2009-04-29       Impact factor: 3.405

9.  Tyrosine phosphatase epsilon is a positive regulator of osteoclast function in vitro and in vivo.

Authors:  Riccardo Chiusaroli; Hilla Knobler; Chen Luxenburg; Archana Sanjay; Shira Granot-Attas; Zohar Tiran; Tsuyoshi Miyazaki; Alon Harmelin; Roland Baron; Ari Elson
Journal:  Mol Biol Cell       Date:  2003-10-03       Impact factor: 4.138

10.  Alpha-actinin synthesis can be modulated by antisense probes and is autoregulated in non-muscle cells.

Authors:  H Schulze; A Huckriede; A A Noegel; M Schleicher; B M Jockusch
Journal:  EMBO J       Date:  1989-12-01       Impact factor: 11.598
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.