Literature DB >> 3034625

A new V gene expressed in lambda-2 light chains of the mouse.

R Dildrop, A Gause, W Müller, K Rajewsky.   

Abstract

We have partially sequenced the light chain variable regions expressed in three IgM-producing hybridomas generated from newborn mice or from manipulated animals suppressed for IgM production. In these lines a new V gene (V-lambda-X), exhibiting less than 60% homology to any known lambda or kappa V gene, is rearranged to J-lambda-2. The light chains produced by these cells contain the lambda-2 constant domain, but are not recognized by goat antisera raised against conventional mouse lambda light chains.

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Year:  1987        PMID： 3034625     DOI： 10.1002/eji.1830170525

Source DB:  PubMed          Journal:  Eur J Immunol        ISSN： 0014-2980            Impact factor:   5.532


  17 in total

Review 1.  Receptor selection in B and T lymphocytes.

Authors:  D Nemazee
Journal:  Annu Rev Immunol       Date:  2000       Impact factor: 28.527

2.  Complex of a protective antibody with its Ebola virus GP peptide epitope: unusual features of a V lambda x light chain.

Authors:  Jeffrey E Lee; Ana Kuehne; Dafna M Abelson; Marnie L Fusco; Mary Kate Hart; Erica Ollmann Saphire
Journal:  J Mol Biol       Date:  2007-10-16       Impact factor: 5.469

3.  A linkage map of the mouse immunoglobulin lambda light chain locus.

Authors:  S Carson; G E Wu
Journal:  Immunogenetics       Date:  1989       Impact factor: 2.846

4.  Physical linkage of mouse lambda genes by pulsed-field gel electrophoresis suggests that the rearrangement process favors proximate target sequences.

Authors:  U Storb; D Haasch; B Arp; P Sanchez; P A Cazenave; J Miller
Journal:  Mol Cell Biol       Date:  1989-02       Impact factor: 4.272

5.  VH replacement in primary immunoglobulin repertoire diversification.

Authors:  Amy Sun; Tatiana I Novobrantseva; Maryaline Coffre; Susannah L Hewitt; Kari Jensen; Jane A Skok; Klaus Rajewsky; Sergei B Koralov
Journal:  Proc Natl Acad Sci U S A       Date:  2015-01-21       Impact factor: 11.205

6.  Immunoglobulin lambda light chain evolution: Igl and Igl-like sequences form three major groups.

Authors:  D J Hayzer
Journal:  Immunogenetics       Date:  1990       Impact factor: 2.846

7.  Transcription and diversity of immunoglobulin lambda chain variable genes in the rat.

Authors:  B A Aguilar; G A Gutman
Journal:  Immunogenetics       Date:  1992       Impact factor: 2.846

8.  Murine V lambda x and V lambda x-containing antibodies bind human myelin basic protein.

Authors:  F S Galin; C C Maier; S R Zhou; J N Whitaker; J E Blalock
Journal:  J Clin Invest       Date:  1996-01-15       Impact factor: 14.808

9.  Structure of a third murine immunoglobulin lambda light chain variable region that is expressed in laboratory mice.

Authors:  P Sanchez; P N Marche; C Le Guern; P A Cazenave
Journal:  Proc Natl Acad Sci U S A       Date:  1987-12       Impact factor: 11.205

10.  Conservation of the immunoglobulin C lambda 5 gene in the Mus gene.

Authors:  F Mami; P A Cazenave; T J Kindt
Journal:  EMBO J       Date:  1988-01       Impact factor: 11.598
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