Literature DB >> 2710121

Physical linkage of mouse lambda genes by pulsed-field gel electrophoresis suggests that the rearrangement process favors proximate target sequences.

U Storb1, D Haasch, B Arp, P Sanchez, P A Cazenave, J Miller.   

Abstract

The first complete map of a mammalian immunoglobulin gene locus is presented. Mouse lambda genes were mapped by pulsed-field gel electrophoresis. The gene order is V2-Vx-C2-C4-V1-C3-C1. The distance between V2 or Vx and the C2-C4 cluster is 74 or 55 kilobases (kb), respectively, whereas that between V1 and C3-C1 is only 19 kb; V2 and C3-C1 are at least 190 kb apart. Thus, the distances between the lambda subloci are inversely proportional to their frequencies of rearrangement. The related gene lambda 5 is not within the 500 kb of the lambda locus mapped here.

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Year:  1989        PMID： 2710121      PMCID： PMC362648          DOI： 10.1128/mcb.9.2.711-718.1989

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  35 in total

1.  A new mouse myeloma cell line that has lost immunoglobulin expression but permits the construction of antibody-secreting hybrid cell lines.

Authors:  J F Kearney; A Radbruch; B Liesegang; K Rajewsky
Journal:  J Immunol       Date:  1979-10       Impact factor: 5.422

2.  Sequences of mouse immunoglobulin light chain genes before and after somatic changes.

Authors:  O Bernard; N Hozumi; S Tonegawa
Journal:  Cell       Date:  1978-12       Impact factor: 41.582

3.  Detection of specific sequences among DNA fragments separated by gel electrophoresis.

Authors:  E M Southern
Journal:  J Mol Biol       Date:  1975-11-05       Impact factor: 5.469

4.  Sequence of a mouse germ-line gene for a variable region of an immunoglobulin light chain.

Authors:  S Tonegawa; A M Maxam; R Tizard; O Bernard; W Gilbert
Journal:  Proc Natl Acad Sci U S A       Date:  1978-03       Impact factor: 11.205

5.  Chromatin structure of endogenous retroviral genes and activation by an inhibitor of DNA methylation.

Authors:  M Groudine; R Eisenman; H Weintraub
Journal:  Nature       Date:  1981-07-23       Impact factor: 49.962

6.  Separation of chromosomal DNA molecules from yeast by orthogonal-field-alternation gel electrophoresis.

Authors:  G F Carle; M V Olson
Journal:  Nucleic Acids Res       Date:  1984-07-25       Impact factor: 16.971

7.  A lymphocyte-specific enhancer in the mouse immunoglobulin kappa gene.

Authors:  D Picard; W Schaffner
Journal:  Nature       Date:  1984 Jan 5-11       Impact factor: 49.962

8.  Separation of yeast chromosome-sized DNAs by pulsed field gradient gel electrophoresis.

Authors:  D C Schwartz; C R Cantor
Journal:  Cell       Date:  1984-05       Impact factor: 41.582

9.  Cellular differentiation, cytidine analogs and DNA methylation.

Authors:  P A Jones; S M Taylor
Journal:  Cell       Date:  1980-05       Impact factor: 41.582

10.  Immunoglobulin gene expression in transformed lymphoid cells.

Authors:  V T Oi; S L Morrison; L A Herzenberg; P Berg
Journal:  Proc Natl Acad Sci U S A       Date:  1983-02       Impact factor: 11.205
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  17 in total

1.  Structure and expression of the human immunoglobulin lambda genes.

Authors:  T J Vasicek; P Leder
Journal:  J Exp Med       Date:  1990-08-01       Impact factor: 14.307

2.  Interaction of a nuclear protein with a palindromic sequence of the mouse immunoglobulin lambda 2-chain gene promoter is important for its transcription.

Authors:  L A Chang; H Murialdo
Journal:  Mol Cell Biol       Date:  1990-11       Impact factor: 4.272

3.  Two conserved essential motifs of the murine immunoglobulin lambda enhancers bind B-cell-specific factors.

Authors:  C M Rudin; U Storb
Journal:  Mol Cell Biol       Date:  1992-01       Impact factor: 4.272

Review 4.  Mouse map of paralogous genes.

Authors:  J H Nadeau; M Kosowsky
Journal:  Mamm Genome       Date:  1991       Impact factor: 2.957

Review 5.  B cell receptor editing in tolerance and autoimmunity.

Authors:  Eline T Luning Prak; Marc Monestier; Robert A Eisenberg
Journal:  Ann N Y Acad Sci       Date:  2011-01-05       Impact factor: 5.691

6.  Immunoglobulin lambda light chain evolution: Igl and Igl-like sequences form three major groups.

Authors:  D J Hayzer
Journal:  Immunogenetics       Date:  1990       Impact factor: 2.846

7.  Physical location of the human immunoglobulin lambda-like genes, 14.1, 16.1, and 16.2.

Authors:  T R Bauer; H E McDermid; M L Budarf; M L Van Keuren; B B Blomberg
Journal:  Immunogenetics       Date:  1993       Impact factor: 2.846

8.  Transcription and diversity of immunoglobulin lambda chain variable genes in the rat.

Authors:  B A Aguilar; G A Gutman
Journal:  Immunogenetics       Date:  1992       Impact factor: 2.846

9.  Influence of CpG methylation and target spacing on V(D)J recombination in a transgenic substrate.

Authors:  P Engler; A Weng; U Storb
Journal:  Mol Cell Biol       Date:  1993-01       Impact factor: 4.272

10.  Isolation of a shark immunoglobulin light chain cDNA clone encoding a protein resembling mammalian kappa light chains: implications for the evolution of light chains.

Authors:  A S Greenberg; L Steiner; M Kasahara; M F Flajnik
Journal:  Proc Natl Acad Sci U S A       Date:  1993-11-15       Impact factor: 11.205
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