Literature DB >> 30345284

Gut-Liver Axis Links Portal Hypertension to Acute-on-Chronic Liver Failure.

Jonel Trebicka1,2,3,4, Thomas Reiberger5,6, Wim Laleman7,8.   

Abstract

Acute-on-chronic liver failure (ACLF) is considered a distinct syndrome in patients with liver disease, with systemic inflammation playing a central role. Portal hypertension (PHT) is also aggravated by inflammation and may subsequently impact the course of ACLF. PHT is more than just an increase in portal pressure in the portal venous system; it aggravates the course of liver disease and, thus, also facilitates the development of acute decompensation and ACLF. A critical mechanistic link between PHT and ACLF might be the gut-liver axis, which is discussed in this review.

Entities:  

Keywords:  Acute-on-chronic liver failure, ACLF; Bacterial translocation; Microbiome; Portal hypertension; Systemic inflammation

Year:  2018        PMID： 30345284      PMCID： PMC6189544          DOI： 10.1159/000490262

Source DB:  PubMed          Journal:  Visc Med        ISSN： 2297-4725


  70 in total

Review 1.  EASL clinical practice guidelines on the management of ascites, spontaneous bacterial peritonitis, and hepatorenal syndrome in cirrhosis.

Authors: 
Journal:  J Hepatol       Date:  2010-06-01       Impact factor: 25.083

2.  Clinical Course of acute-on-chronic liver failure syndrome and effects on prognosis.

Authors:  Thierry Gustot; Javier Fernandez; Elisabet Garcia; Filippo Morando; Paolo Caraceni; Carlo Alessandria; Wim Laleman; Jonel Trebicka; Laure Elkrief; Corinna Hopf; Pablo Solís-Munoz; Faouzi Saliba; Stefan Zeuzem; Augustin Albillos; Daniel Benten; José Luis Montero-Alvarez; Maria Teresa Chivas; Mar Concepción; Juan Córdoba; Aiden McCormick; Rudolf Stauber; Wolfgang Vogel; Andrea de Gottardi; Tania M Welzel; Marco Domenicali; Alessandro Risso; Julia Wendon; Carme Deulofeu; Paolo Angeli; François Durand; Marco Pavesi; Alexander Gerbes; Rajiv Jalan; Richard Moreau; Pere Ginés; Mauro Bernardi; Vicente Arroyo
Journal:  Hepatology       Date:  2015-05-29       Impact factor: 17.425

3.  Systemic inflammation in decompensated cirrhosis: Characterization and role in acute-on-chronic liver failure.

Authors:  Joan Clària; Rudolf E Stauber; Minneke J Coenraad; Richard Moreau; Rajiv Jalan; Marco Pavesi; Àlex Amorós; Esther Titos; José Alcaraz-Quiles; Karl Oettl; Manuel Morales-Ruiz; Paolo Angeli; Marco Domenicali; Carlo Alessandria; Alexander Gerbes; Julia Wendon; Frederik Nevens; Jonel Trebicka; Wim Laleman; Faouzi Saliba; Tania M Welzel; Agustin Albillos; Thierry Gustot; Daniel Benten; François Durand; Pere Ginès; Mauro Bernardi; Vicente Arroyo
Journal:  Hepatology       Date:  2016-08-25       Impact factor: 17.425

4.  Early use of TIPS in patients with cirrhosis and variceal bleeding.

Authors:  Juan Carlos García-Pagán; Karel Caca; Christophe Bureau; Wim Laleman; Beate Appenrodt; Angelo Luca; Juan G Abraldes; Frederik Nevens; Jean Pierre Vinel; Joachim Mössner; Jaime Bosch
Journal:  N Engl J Med       Date:  2010-06-24       Impact factor: 91.245

5.  Hepatic and systemic hemodynamic derangements predict early mortality and recovery in patients with acute-on-chronic liver failure.

Authors:  Hitendra Garg; Ashish Kumar; Vishal Garg; Manoj Kumar; Ramesh Kumar; Barjesh Chander Sharma; Shiv Kumar Sarin
Journal:  J Gastroenterol Hepatol       Date:  2013-08       Impact factor: 4.029

Review 6.  Acute-on-chronic liver failure.

Authors:  Sumeet K Asrani; Jacqueline G O'Leary
Journal:  Clin Liver Dis       Date:  2014-08       Impact factor: 6.126

7.  The use of human albumin in patients with cirrhosis: a European survey.

Authors:  Paolo Caraceni; Marco Pavesi; Maurizio Baldassarre; Mauro Bernardi; Vicente Arroyo
Journal:  Expert Rev Gastroenterol Hepatol       Date:  2018-04-04       Impact factor: 3.869

Review 8.  Acute-on-chronic liver failure: an update.

Authors:  Ruben Hernaez; Elsa Solà; Richard Moreau; Pere Ginès
Journal:  Gut       Date:  2017-01-04       Impact factor: 23.059

9.  Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990-2013: quantifying the epidemiological transition.

Authors:  Christopher J L Murray; Ryan M Barber; Kyle J Foreman; Ayse Abbasoglu Ozgoren; Foad Abd-Allah; Semaw F Abera; Victor Aboyans; Jerry P Abraham; Ibrahim Abubakar; Laith J Abu-Raddad; Niveen M Abu-Rmeileh; Tom Achoki; Ilana N Ackerman; Zanfina Ademi; Arsène K Adou; José C Adsuar; Ashkan Afshin; Emilie E Agardh; Sayed Saidul Alam; Deena Alasfoor; Mohammed I Albittar; Miguel A Alegretti; Zewdie A Alemu; Rafael Alfonso-Cristancho; Samia Alhabib; Raghib Ali; François Alla; Peter Allebeck; Mohammad A Almazroa; Ubai Alsharif; Elena Alvarez; Nelson Alvis-Guzman; Azmeraw T Amare; Emmanuel A Ameh; Heresh Amini; Walid Ammar; H Ross Anderson; Benjamin O Anderson; Carl Abelardo T Antonio; Palwasha Anwari; Johan Arnlöv; Valentina S Arsic Arsenijevic; Al Artaman; Rana J Asghar; Reza Assadi; Lydia S Atkins; Marco A Avila; Baffour Awuah; Victoria F Bachman; Alaa Badawi; Maria C Bahit; Kalpana Balakrishnan; Amitava Banerjee; Suzanne L Barker-Collo; Simon Barquera; Lars Barregard; Lope H Barrero; Arindam Basu; Sanjay Basu; Mohammed O Basulaiman; Justin Beardsley; Neeraj Bedi; Ettore Beghi; Tolesa Bekele; Michelle L Bell; Corina Benjet; Derrick A Bennett; Isabela M Bensenor; Habib Benzian; Eduardo Bernabé; Amelia Bertozzi-Villa; Tariku J Beyene; Neeraj Bhala; Ashish Bhalla; Zulfiqar A Bhutta; Kelly Bienhoff; Boris Bikbov; Stan Biryukov; Jed D Blore; Christopher D Blosser; Fiona M Blyth; Megan A Bohensky; Ian W Bolliger; Berrak Bora Başara; Natan M Bornstein; Dipan Bose; Soufiane Boufous; Rupert R A Bourne; Lindsay N Boyers; Michael Brainin; Carol E Brayne; Alexandra Brazinova; Nicholas J K Breitborde; Hermann Brenner; Adam D Briggs; Peter M Brooks; Jonathan C Brown; Traolach S Brugha; Rachelle Buchbinder; Geoffrey C Buckle; Christine M Budke; Anne Bulchis; Andrew G Bulloch; Ismael R Campos-Nonato; Hélène Carabin; Jonathan R Carapetis; Rosario Cárdenas; David O Carpenter; Valeria Caso; Carlos A Castañeda-Orjuela; Ruben E Castro; Ferrán Catalá-López; Fiorella Cavalleri; Alanur Çavlin; 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Veena S Kulkarni; G Anil Kumar; Hmwe H Kyu; Taavi Lai; Ratilal Lalloo; Tea Lallukka; Hilton Lam; Qing Lan; Van C Lansingh; Anders Larsson; Alicia E B Lawrynowicz; Janet L Leasher; James Leigh; Ricky Leung; Carly E Levitz; Bin Li; Yichong Li; Yongmei Li; Stephen S Lim; Maggie Lind; Steven E Lipshultz; Shiwei Liu; Yang Liu; Belinda K Lloyd; Katherine T Lofgren; Giancarlo Logroscino; Katharine J Looker; Joannie Lortet-Tieulent; Paulo A Lotufo; Rafael Lozano; Robyn M Lucas; Raimundas Lunevicius; Ronan A Lyons; Stefan Ma; Michael F Macintyre; Mark T Mackay; Marek Majdan; Reza Malekzadeh; Wagner Marcenes; David J Margolis; Christopher Margono; Melvin B Marzan; Joseph R Masci; Mohammad T Mashal; Richard Matzopoulos; Bongani M Mayosi; Tasara T Mazorodze; Neil W Mcgill; John J Mcgrath; Martin Mckee; Abigail Mclain; Peter A Meaney; Catalina Medina; Man Mohan Mehndiratta; Wubegzier Mekonnen; Yohannes A Melaku; Michele Meltzer; Ziad A Memish; George A Mensah; Atte Meretoja; Francis A Mhimbira; Renata Micha; 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Jae-Hyun Park; Scott B Patten; George C Patton; Vinod K Paul; Boris I Pavlin; Neil Pearce; David M Pereira; Rogelio Perez-Padilla; Fernando Perez-Ruiz; Norberto Perico; Aslam Pervaiz; Konrad Pesudovs; Carrie B Peterson; Max Petzold; Michael R Phillips; Bryan K Phillips; David E Phillips; Frédéric B Piel; Dietrich Plass; Dan Poenaru; Suzanne Polinder; Daniel Pope; Svetlana Popova; Richie G Poulton; Farshad Pourmalek; Dorairaj Prabhakaran; Noela M Prasad; Rachel L Pullan; Dima M Qato; D Alex Quistberg; Anwar Rafay; Kazem Rahimi; Sajjad U Rahman; Murugesan Raju; Saleem M Rana; Homie Razavi; K Srinath Reddy; Amany Refaat; Giuseppe Remuzzi; Serge Resnikoff; Antonio L Ribeiro; Lee Richardson; Jan Hendrik Richardus; D Allen Roberts; David Rojas-Rueda; Luca Ronfani; Gregory A Roth; Dietrich Rothenbacher; David H Rothstein; Jane T Rowley; Nobhojit Roy; George M Ruhago; Mohammad Y Saeedi; Sukanta Saha; Mohammad Ali Sahraian; Uchechukwu K A Sampson; Juan R Sanabria; Logan Sandar; Itamar S Santos; Maheswar Satpathy; Monika Sawhney; Peter Scarborough; Ione J Schneider; Ben Schöttker; Austin E Schumacher; David C Schwebel; James G Scott; Soraya Seedat; Sadaf G Sepanlou; Peter T Serina; Edson E Servan-Mori; Katya A Shackelford; Amira Shaheen; Saeid Shahraz; Teresa Shamah Levy; Siyi Shangguan; Jun She; Sara Sheikhbahaei; Peilin Shi; Kenji Shibuya; Yukito Shinohara; Rahman Shiri; Kawkab Shishani; Ivy Shiue; Mark G Shrime; Inga D Sigfusdottir; Donald H Silberberg; Edgar P Simard; Shireen Sindi; Abhishek Singh; Jasvinder A Singh; Lavanya Singh; Vegard Skirbekk; Erica Leigh Slepak; Karen Sliwa; Samir Soneji; Kjetil Søreide; Sergey Soshnikov; Luciano A Sposato; Chandrashekhar T Sreeramareddy; Jeffrey D Stanaway; Vasiliki Stathopoulou; Dan J Stein; Murray B Stein; Caitlyn Steiner; Timothy J Steiner; Antony Stevens; Andrea Stewart; Lars J Stovner; Konstantinos Stroumpoulis; Bruno F Sunguya; Soumya Swaminathan; Mamta Swaroop; Bryan L Sykes; Karen M Tabb; Ken Takahashi; Nikhil Tandon; David Tanne; Marcel Tanner; Mohammad Tavakkoli; Hugh R Taylor; Braden J Te Ao; Fabrizio Tediosi; Awoke M Temesgen; Tara Templin; Margreet Ten Have; Eric Y Tenkorang; Abdullah S Terkawi; Blake Thomson; Andrew L Thorne-Lyman; Amanda G Thrift; George D Thurston; Taavi Tillmann; Marcello Tonelli; Fotis Topouzis; Hideaki Toyoshima; Jefferson Traebert; Bach X Tran; Matias Trillini; Thomas Truelsen; Miltiadis Tsilimbaris; Emin M Tuzcu; Uche S Uchendu; Kingsley N Ukwaja; Eduardo A Undurraga; Selen B Uzun; Wim H Van Brakel; Steven Van De Vijver; Coen H van Gool; Jim Van Os; Tommi J Vasankari; N Venketasubramanian; Francesco S Violante; Vasiliy V Vlassov; Stein Emil Vollset; Gregory R Wagner; Joseph Wagner; Stephen G Waller; Xia Wan; Haidong Wang; Jianli Wang; Linhong Wang; Tati S Warouw; Scott Weichenthal; Elisabete Weiderpass; Robert G Weintraub; Wang Wenzhi; Andrea Werdecker; Ronny Westerman; Harvey A Whiteford; James D Wilkinson; Thomas N Williams; Charles D Wolfe; Timothy M Wolock; Anthony D Woolf; Sarah Wulf; Brittany Wurtz; Gelin Xu; Lijing L Yan; Yuichiro Yano; Pengpeng Ye; Gökalp K Yentür; Paul Yip; Naohiro Yonemoto; Seok-Jun Yoon; Mustafa Z Younis; Chuanhua Yu; Maysaa E Zaki; Yong Zhao; Yingfeng Zheng; David Zonies; Xiaonong Zou; Joshua A Salomon; Alan D Lopez; Theo Vos
Journal:  Lancet       Date:  2015-08-28       Impact factor: 79.321

10.  Extensive impact of non-antibiotic drugs on human gut bacteria.

Authors:  Lisa Maier; Mihaela Pruteanu; Michael Kuhn; Georg Zeller; Anja Telzerow; Exene Erin Anderson; Ana Rita Brochado; Keith Conrad Fernandez; Hitomi Dose; Hirotada Mori; Kiran Raosaheb Patil; Peer Bork; Athanasios Typas
Journal:  Nature       Date:  2018-03-19       Impact factor: 49.962
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  11 in total

Review 1.  Utilizing the gut microbiome in decompensated cirrhosis and acute-on-chronic liver failure.

Authors:  Jonel Trebicka; Peer Bork; Aleksander Krag; Manimozhiyan Arumugam
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2020-11-30       Impact factor: 46.802

Review 2.  The microbiota in cirrhosis and its role in hepatic decompensation.

Authors:  Jonel Trebicka; Jane Macnaughtan; Bernd Schnabl; Debbie L Shawcross; Jasmohan S Bajaj
Journal:  J Hepatol       Date:  2021-07       Impact factor: 30.083

3.  Increased Endotoxin Activity Is Associated with the Risk of Developing Acute-on-Chronic Liver Failure.

Authors:  Hiroaki Takaya; Tadashi Namisaki; Shinya Sato; Kosuke Kaji; Yuki Tsuji; Daisuke Kaya; Yukihisa Fujinaga; Yasuhiko Sawada; Naotaka Shimozato; Hideto Kawaratani; Kei Moriya; Takemi Akahane; Akira Mitoro; Hitoshi Yoshiji
Journal:  J Clin Med       Date:  2020-05-14       Impact factor: 4.241

4.  Portal hypertensive gastropathy is associated with iron deficiency anemia.

Authors:  Benedikt Simbrunner; Andrea Beer; Katharina Wöran; Fabian Schmitz; Christian Primas; Marlene Wewalka; Matthias Pinter; Werner Dolak; Bernhard Scheiner; Andreas Puespoek; Michael Trauner; Georg Oberhuber; Mattias Mandorfer; Thomas Reiberger
Journal:  Wien Klin Wochenschr       Date:  2020-01-07       Impact factor: 1.704

5.  The Role of Macrophage-Inducible C-Type Lectin in Different Stages of Chronic Liver Disease.

Authors:  Robert Schierwagen; Frank E Uschner; Cristina Ortiz; Sandra Torres; Max J Brol; Olaf Tyc; Wenyi Gu; Christian Grimm; Stefan Zeuzem; Andreas Plamper; Philipp Pfeifer; Sebastian Zimmer; Christoph Welsch; Liliana Schaefer; Karl P Rheinwalt; Joan Clària; Vicente Arroyo; Jonel Trebicka; Sabine Klein
Journal:  Front Immunol       Date:  2020-07-07       Impact factor: 7.561

Review 6.  Gut-liver axis signaling in portal hypertension.

Authors:  Benedikt Simbrunner; Mattias Mandorfer; Michael Trauner; Thomas Reiberger
Journal:  World J Gastroenterol       Date:  2019-10-21       Impact factor: 5.742

7.  Haemodynamic changes in cirrhosis following terlipressin and induction of sepsis-a preclinical study using caval subtraction phase-contrast and cardiac MRI.

Authors:  Manil D Chouhan; Stuart A Taylor; Alan Bainbridge; Simon Walker-Samuel; Nathan Davies; Steve Halligan; Mark F Lythgoe; Rajeshwar P Mookerjee
Journal:  Eur Radiol       Date:  2020-10-12       Impact factor: 5.315

Review 8.  Portal hypertension in cirrhosis: Pathophysiological mechanisms and therapy.

Authors:  Yasuko Iwakiri; Jonel Trebicka
Journal:  JHEP Rep       Date:  2021-06-04

9.  Cirrhosis-Associated RAS-Inflammation-Coagulation Axis Anomalies: Parallels to Severe COVID-19.

Authors:  Lukas Hartl; Mathias Jachs; Benedikt Simbrunner; David J M Bauer; Georg Semmler; Daniela Gompelmann; Thomas Szekeres; Peter Quehenberger; Michael Trauner; Mattias Mandorfer; Bernhard Scheiner; Thomas Reiberger
Journal:  J Pers Med       Date:  2021-12-01

Review 10.  The Use of Rifaximin in Patients With Cirrhosis.

Authors:  Paolo Caraceni; Victor Vargas; Elsa Solà; Carlo Alessandria; Koos de Wit; Jonel Trebicka; Paolo Angeli; Rajeshwar P Mookerjee; François Durand; Elisa Pose; Aleksander Krag; Jasmohan S Bajaj; Ulrich Beuers; Pere Ginès
Journal:  Hepatology       Date:  2021-06-07       Impact factor: 17.425
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