Literature DB >> 3034146

Effect of calcium on in vitro activity of LY146032 against Clostridium difficile.

H Faruki, A C Niles, R L Heeren, P R Murray.   

Abstract

The in vitro MICs of LY146032 against 63 isolates of Clostridium difficile tested in Wilkins-Chalgren broth ranged from 0.5 to greater than 32 micrograms/ml, with MICs of 4 and 8 micrograms/ml for 50 and 90% of the isolates, respectively. However, when the test medium was supplemented with physiologic concentrations of calcium, the MIC for 90% of the isolates was reduced to less than or equal to 0.12 microgram/ml.

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Year:  1987        PMID： 3034146      PMCID： PMC174753          DOI： 10.1128/AAC.31.3.461

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  2 in total

1.  Medium for use in antibiotic susceptibility testing of anaerobic bacteria.

Authors:  T D Wilkins; S Chalgren
Journal:  Antimicrob Agents Chemother       Date:  1976-12       Impact factor: 5.191

2.  In vitro activity and mechanism of action of A21978C1, a novel cyclic lipopeptide antibiotic.

Authors:  G M Eliopoulos; C Thauvin; B Gerson; R C Moellering
Journal:  Antimicrob Agents Chemother       Date:  1985-03       Impact factor: 5.191
  2 in total
  8 in total

1.  Effects of reduced cation supplement recommendations (National Committee for Clinical Laboratory Standards) on daptomycin antistaphylococcal activity.

Authors:  R N Jones
Journal:  Antimicrob Agents Chemother       Date:  1989-09       Impact factor: 5.191

2.  Treatment of Clostridium difficile colitis in hamsters with a lipopeptide antibiotic, LY146032.

Authors:  M Y Dong; T W Chang; S L Gorbach
Journal:  Antimicrob Agents Chemother       Date:  1987-07       Impact factor: 5.191

3.  In vitro activities of daptomycin (LY146032) and paldimycin (U-70,138F) against anaerobic gram-positive bacteria.

Authors:  A W Chow; N Cheng
Journal:  Antimicrob Agents Chemother       Date:  1988-05       Impact factor: 5.191

4.  Lipoteichoic acid as a new target for activity of antibiotics: mode of action of daptomycin (LY146032).

Authors:  P Canepari; M Boaretti; M M Lleó; G Satta
Journal:  Antimicrob Agents Chemother       Date:  1990-06       Impact factor: 5.191

5.  In vitro susceptibility studies of vancomycin-resistant Enterococcus faecalis.

Authors:  D F Sahm; J Kissinger; M S Gilmore; P R Murray; R Mulder; J Solliday; B Clarke
Journal:  Antimicrob Agents Chemother       Date:  1989-09       Impact factor: 5.191

6.  In vitro activities of daptomycin, vancomycin, quinupristin- dalfopristin, linezolid, and five other antimicrobials against 307 gram-positive anaerobic and 31 Corynebacterium clinical isolates.

Authors:  Ellie J C Goldstein; Diane M Citron; C Vreni Merriam; Yumi A Warren; Kerrin L Tyrrell; Helen T Fernandez
Journal:  Antimicrob Agents Chemother       Date:  2003-01       Impact factor: 5.191

7.  Comparative in vitro antibiotic resistance of surface-colonizing coagulase-negative staphylococci.

Authors:  A G Gristina; R A Jennings; P T Naylor; Q N Myrvik; L X Webb
Journal:  Antimicrob Agents Chemother       Date:  1989-06       Impact factor: 5.191

8.  Susceptibility testing of clinical isolates of Enterococcus faecium and Enterococcus faecalis.

Authors:  M Louie; A E Simor; S Szeto; M Patel; B Kreiswirth; D E Low
Journal:  J Clin Microbiol       Date:  1992-01       Impact factor: 5.948
  8 in total

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