Literature DB >> 2821892

Treatment of Clostridium difficile colitis in hamsters with a lipopeptide antibiotic, LY146032.

M Y Dong1, T W Chang, S L Gorbach.   

Abstract

LY146032, an acidic lipopeptide antibiotic which inhibits the biosynthesis of cell wall peptidoglycan, was found to be effective in delaying death in a hamster model of pseudomembranous colitis. A dose of 0.05 mg/day was effective. The equivalent protection with vancomycin required a dose 100-fold higher, i.e., 5 mg/day.

Entities:  

Mesh：

Substances：

Year:  1987        PMID： 2821892      PMCID： PMC174884          DOI： 10.1128/AAC.31.7.1135

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  4 in total

1.  The protective effect of vancomycin on clindamycin-induced colitis in hamsters.

Authors:  R A Browne; R Fekety; J Silva; D I Boyd; C O Work; G D Abrams
Journal:  Johns Hopkins Med J       Date:  1977-10

2.  Effect of calcium on in vitro activity of LY146032 against Clostridium difficile.

Authors:  H Faruki; A C Niles; R L Heeren; P R Murray
Journal:  Antimicrob Agents Chemother       Date:  1987-03       Impact factor: 5.191

3.  Clindamycin-associated colitis due to a toxin-producing species of Clostridium in hamsters.

Authors:  J G Bartlett; A B Onderdonk; R L Cisneros; D L Kasper
Journal:  J Infect Dis       Date:  1977-11       Impact factor: 5.226

4.  Neutralization of Clostridium difficile toxin by Clostridium sordellii antitoxins.

Authors:  T W Chang; S L Gorbach; J B Bartlett
Journal:  Infect Immun       Date:  1978-11       Impact factor: 3.441
  4 in total
  9 in total

1.  Efficacy of LFF571 in a hamster model of Clostridium difficile infection.

Authors:  Anna Trzasko; Jennifer A Leeds; Jens Praestgaard; Matthew J Lamarche; David McKenney
Journal:  Antimicrob Agents Chemother       Date:  2012-05-29       Impact factor: 5.191

Review 2.  Current perspectives on glycopeptide resistance.

Authors:  N Woodford; A P Johnson; D Morrison; D C Speller
Journal:  Clin Microbiol Rev       Date:  1995-10       Impact factor: 26.132

Review 3.  Models for the study of Clostridium difficile infection.

Authors:  Emma L Best; Jane Freeman; Mark H Wilcox
Journal:  Gut Microbes       Date:  2012-03-01

4.  In vitro activities of daptomycin (LY146032) and paldimycin (U-70,138F) against anaerobic gram-positive bacteria.

Authors:  A W Chow; N Cheng
Journal:  Antimicrob Agents Chemother       Date:  1988-05       Impact factor: 5.191

5.  In vitro and in vivo evaluation of tiacumicins B and C against Clostridium difficile.

Authors:  R N Swanson; D J Hardy; N L Shipkowitz; C W Hanson; N C Ramer; P B Fernandes; J J Clement
Journal:  Antimicrob Agents Chemother       Date:  1991-06       Impact factor: 5.191

6.  In vitro activities of daptomycin, vancomycin, quinupristin- dalfopristin, linezolid, and five other antimicrobials against 307 gram-positive anaerobic and 31 Corynebacterium clinical isolates.

Authors:  Ellie J C Goldstein; Diane M Citron; C Vreni Merriam; Yumi A Warren; Kerrin L Tyrrell; Helen T Fernandez
Journal:  Antimicrob Agents Chemother       Date:  2003-01       Impact factor: 5.191

7.  Effect of the Synthetic Bile Salt Analog CamSA on the Hamster Model of Clostridium difficile Infection.

Authors:  Amber Howerton; Cale O Seymour; Senthil K Murugapiran; Zhenlin Liao; Jacqueline R Phan; Alan Estrada; Adam J Wagner; Chrisabelle C Mefferd; Brian P Hedlund; Ernesto Abel-Santos
Journal:  Antimicrob Agents Chemother       Date:  2018-09-24       Impact factor: 5.191

Review 8.  Daptomycin: a cyclic lipopeptide antimicrobial agent.

Authors:  LilyAnn Jeu; Horatio B Fung
Journal:  Clin Ther       Date:  2004-11       Impact factor: 3.393

9.  A High-Carbohydrate Diet Prolongs Dysbiosis and Clostridioides difficile Carriage and Increases Delayed Mortality in a Hamster Model of Infection.

Authors:  Shrikant S Bhute; Chrisabelle C Mefferd; Jacqueline R Phan; Muneeba Ahmed; Amelia E Fox-King; Stephanie Alarcia; Jacob V Villarama; Ernesto Abel-Santos; Brian P Hedlund
Journal:  Microbiol Spectr       Date:  2022-06-16
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.