Literature DB >> 3033424

In vivo 31P NMR spectroscopy of agonist-stimulated phosphatidylinositol metabolism in cat brain.

P F Renshaw, M D Schnall, J S Leigh.   

Abstract

As a result of the agonist stimulation of muscarinic receptors, myo-inositol-1-phosphate accumulates in the presence of millimolar lithium concentrations. This accumulation of myo-inositol-1-phosphate can be detected by in vivo 31P NMR spectroscopy. Since myo-inositol-1-phosphate is a breakdown product of phosphatidylinositol, this may provide a means of noninvasively monitoring phosphatidylinositol metabolism in vivo.

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Year:  1987        PMID: 3033424     DOI: 10.1002/mrm.1910040303

Source DB:  PubMed          Journal:  Magn Reson Med        ISSN: 0740-3194            Impact factor:   4.668


  2 in total

Review 1.  Mitochondrial dysfunction as the molecular basis of bipolar disorder: therapeutic implications.

Authors:  Tadafumi Kato
Journal:  CNS Drugs       Date:  2007       Impact factor: 5.749

Review 2.  Neurochemical predictors of response to pharmacologic treatments for bipolar disorder.

Authors:  Melissa P Delbello; Stephen M Strakowski
Journal:  Curr Psychiatry Rep       Date:  2004-12       Impact factor: 8.081

  2 in total

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