Marije L S Sleijser-Koehorst1,2, Michel W Coppieters1,3,4, Martijn W Heymans5, Servan Rooker6, Arianne P Verhagen7,8, Gwendolijne G M Scholten-Peeters9,10,11. 1. Department of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Van der Boechorststraat 9, 1081 BT, Amsterdam, The Netherlands. 2. SOMT University of Physiotherapy, Amersfoort, The Netherlands. 3. The Hopkins Centre, Menzies Health Institute Queensland, Griffith University, Gold Coast, Australia. 4. School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, Australia. 5. Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands. 6. Department of Neurosurgery and Orthopaedics, Kliniek ViaSana, Mill, The Netherlands. 7. Department of General Practice, Erasmus University Medical Center, Rotterdam, The Netherlands. 8. Department of Physiotherapy, Graduate School of Health, University of Technology Sydney, Sydney, Australia. 9. Department of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Van der Boechorststraat 9, 1081 BT, Amsterdam, The Netherlands. g.g.m.scholten-peeters@vu.nl. 10. SOMT University of Physiotherapy, Amersfoort, The Netherlands. g.g.m.scholten-peeters@vu.nl. 11. Department of Neurosurgery and Orthopaedics, Kliniek ViaSana, Mill, The Netherlands. g.g.m.scholten-peeters@vu.nl.
Abstract
PURPOSE: To describe the clinical course and develop prognostic models for poor recovery in patients with cervical radiculopathy who are managed conservatively. METHODS: Sixty-one consecutive adults with cervical radiculopathy who were referred for conservative management were included in a prospective cohort study, with 6- and 12-month follow-up assessments. Exclusion criteria were the presence of known serious pathology or spinal surgery in the past. Outcome measures were perceived recovery, neck pain intensity and disability level. Multiple imputation analyses were performed for missing values. Prognostic models were developed using multivariable logistic regression analyses, with bootstrapping techniques for internal validation. RESULTS: About 55% of participants reported to be recovered at 6 and 12 months. All multivariable models contained 2 baseline predictors. Longer symptoms duration increased the risk of poor perceived recovery, whereas the presence of paresthesia decreased this risk. A higher neck pain intensity and a longer duration of symptoms increased the risk of poor relief of neck pain. A higher disability score increased the risk of poor relief of disability, and larger active range of rotation toward the affected side decreased this risk. Following bootstrapping, the explained variance of the models varied between 0.22 and 0.30, and the median area under the curve varied between 0.75 and 0.79. CONCLUSIONS: The clinical course of cervical radiculopathy appears to be long, with most of the reduction in symptoms occurring within the first 6 months. All prognostic models showed an adequate predictive performance with modest diagnostic accuracy and explained variance. These slides can be retrieved under Electronic Supplementary Material.
PURPOSE: To describe the clinical course and develop prognostic models for poor recovery in patients with cervical radiculopathy who are managed conservatively. METHODS: Sixty-one consecutive adults with cervical radiculopathy who were referred for conservative management were included in a prospective cohort study, with 6- and 12-month follow-up assessments. Exclusion criteria were the presence of known serious pathology or spinal surgery in the past. Outcome measures were perceived recovery, neck pain intensity and disability level. Multiple imputation analyses were performed for missing values. Prognostic models were developed using multivariable logistic regression analyses, with bootstrapping techniques for internal validation. RESULTS: About 55% of participants reported to be recovered at 6 and 12 months. All multivariable models contained 2 baseline predictors. Longer symptoms duration increased the risk of poor perceived recovery, whereas the presence of paresthesia decreased this risk. A higher neck pain intensity and a longer duration of symptoms increased the risk of poor relief of neck pain. A higher disability score increased the risk of poor relief of disability, and larger active range of rotation toward the affected side decreased this risk. Following bootstrapping, the explained variance of the models varied between 0.22 and 0.30, and the median area under the curve varied between 0.75 and 0.79. CONCLUSIONS: The clinical course of cervical radiculopathy appears to be long, with most of the reduction in symptoms occurring within the first 6 months. All prognostic models showed an adequate predictive performance with modest diagnostic accuracy and explained variance. These slides can be retrieved under Electronic Supplementary Material.
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