Haitang Qiu1, Xinke Li2, Qinghua Luo1, Yongming Li3, Xichuan Zhou4, Hailin Cao4, Yuanhong Zhong4, Mingui Sun5. 1. Mental Health Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, PR China. 2. College of Communication Engineering, Chongqing University, Chongqing 400044, PR China; Collaborative innovation center for brain science, Chongqing University, Chongqing 400044, PR China; Department of Neurosurgery, University of Pittsburgh, Pittsburgh 15213, PA, USA. Electronic address: lxk@cqu.edu.cn. 3. College of Communication Engineering, Chongqing University, Chongqing 400044, PR China; Collaborative innovation center for brain science, Chongqing University, Chongqing 400044, PR China. 4. College of Communication Engineering, Chongqing University, Chongqing 400044, PR China. 5. Department of Neurosurgery, University of Pittsburgh, Pittsburgh 15213, PA, USA.
Abstract
BACKGROUND: Electroconvulsive therapy (ECT) is an important treatment option for patients with major depressive disorder (MDD). However, the mechanisms of ECT in MDD are still unclear. METHODS: Twenty-four patients with severe MDD and 14 healthy controls were enrolled in this study. Eight ECT sessions were conducted for MDD patients using brief-pulse square-wave signal at bitemporal locations. To investigate the regional cerebral blood flow in MDD patients before and after ECT treatments by resting-state functional magnetic resonance imaging (rs-fMRI), the patients were scanned twice (before the first ECT and after the eighth ECT) for data acquisition. Afterward, we adopted fractional amplitude of low-frequency fluctuations (fALFF) to assess the alterations of regional brain activity. RESULTS: Compared with healthy controls, the fALFF in the cerebellum lobe, parahippocampal gyrus, fusiform gyrus, anterior cingulate gyrus, and thalamus in MDD patients before ECT (pre-ECT) was significantly increased. In another comparison, the fALFF in the cerebellum anterior lobe, fusiform gyrus, insula, parahippocampal gyrus, middle frontal gyrus, and inferior frontal gyrus in pre-ECT patients was significantly greater than the post-ECT fALFF. LIMITATIONS: Only two rs-fMRI scans were conducted at predefined times: before the first and after the eighth ECT treatment. More scans during the ECT sessions would yield more information. In addition, the sample size in this study was limited. The number of control subjects was relatively small. A larger number of subjects would produce more robust findings. CONCLUSIONS: The fALFF of both healthy controls and post-ECT patients in cerebellum anterior lobe, fusiform gyrus, and parahippocampal gyrus is significantly lower than the fALFF of pre-ECT patients. This finding demonstrates that ECT treatment is effective on these brain areas in MDD patients.
BACKGROUND: Electroconvulsive therapy (ECT) is an important treatment option for patients with major depressive disorder (MDD). However, the mechanisms of ECT in MDD are still unclear. METHODS: Twenty-four patients with severe MDD and 14 healthy controls were enrolled in this study. Eight ECT sessions were conducted for MDDpatients using brief-pulse square-wave signal at bitemporal locations. To investigate the regional cerebral blood flow in MDDpatients before and after ECT treatments by resting-state functional magnetic resonance imaging (rs-fMRI), the patients were scanned twice (before the first ECT and after the eighth ECT) for data acquisition. Afterward, we adopted fractional amplitude of low-frequency fluctuations (fALFF) to assess the alterations of regional brain activity. RESULTS: Compared with healthy controls, the fALFF in the cerebellum lobe, parahippocampal gyrus, fusiform gyrus, anterior cingulate gyrus, and thalamus in MDDpatients before ECT (pre-ECT) was significantly increased. In another comparison, the fALFF in the cerebellum anterior lobe, fusiform gyrus, insula, parahippocampal gyrus, middle frontal gyrus, and inferior frontal gyrus in pre-ECT patients was significantly greater than the post-ECT fALFF. LIMITATIONS: Only two rs-fMRI scans were conducted at predefined times: before the first and after the eighth ECT treatment. More scans during the ECT sessions would yield more information. In addition, the sample size in this study was limited. The number of control subjects was relatively small. A larger number of subjects would produce more robust findings. CONCLUSIONS: The fALFF of both healthy controls and post-ECT patients in cerebellum anterior lobe, fusiform gyrus, and parahippocampal gyrus is significantly lower than the fALFF of pre-ECT patients. This finding demonstrates that ECT treatment is effective on these brain areas in MDDpatients.
Authors: Jason A Avery; Wayne C Drevets; Scott E Moseman; Jerzy Bodurka; Joel C Barcalow; W Kyle Simmons Journal: Biol Psychiatry Date: 2013-12-08 Impact factor: 13.382
Authors: Jonathan Posner; David J Hellerstein; Inbal Gat; Anna Mechling; Kristin Klahr; Zhishun Wang; Patrick J McGrath; Jonathan W Stewart; Bradley S Peterson Journal: JAMA Psychiatry Date: 2013-04 Impact factor: 21.596
Authors: Conor Liston; Ashley C Chen; Benjamin D Zebley; Andrew T Drysdale; Rebecca Gordon; Bruce Leuchter; Henning U Voss; B J Casey; Amit Etkin; Marc J Dubin Journal: Biol Psychiatry Date: 2014-02-05 Impact factor: 13.382
Authors: Hossein Dini; Mohammad S E Sendi; Jing Sui; Zening Fu; Randall Espinoza; Katherine L Narr; Shile Qi; Christopher C Abbott; Sanne J H van Rooij; Patricio Riva-Posse; Luis Emilio Bruni; Helen S Mayberg; Vince D Calhoun Journal: Front Hum Neurosci Date: 2021-07-06 Impact factor: 3.169