Mehdi Koushki1,2, Nasrin Amiri Dash Atan3,2, Hossein Omidi-Ardali1, Mostafa Rezaei Tavirani3. 1. Biochemistry Department, Medicine Faculty, Tehran University of Medical Sciences, Tehran, Iran. 2. The first and the second authors contributed equally to this work. 3. Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Abstract
BACKGROUND: Pre-eclampsia (PE) is a pregnancy disorder characterized by hypertension and proteinuria. The evidence has suggested that microRNAs (miRs) are associated with pre-eclampsia pathogenesis; however, these results are inconsistent. The aim of this study was to assess the association between miR-210 expression and PE risk. METHODS: Previous studies were selected using PubMed, Scopus, MEDLINE, EMBASE, Science Direct, Google Scholar, Directory of Open Access Journals (DOAJ), and Scientific Information Database (SID). This metaanalysis includes 12 studies associated with miR-210 and pre-eclampsia and necessary information was extracted. RESULTS: The standardized mean differences [(SMD (0.32) 95% CI (014-0.49), p=0.97] and heterogeneity were determined with the chi-square test (Q=3.63 df =11 p= 0.97), which found no heterogeneity between these studies. Additionally, publication bias was evaluated by Egger's and Begg´s tests. Visual inspection of the funnel plot graphically, and statistically with Egger's weighted regression [(p= 0.35) (95% CI -0.90 - 2.29)] and Begg's rank correlation (p= 0.21), found no important publication bias between studies within the meta-analysis. CONCLUSION: Our findings suggest that miR-210 contributes to the pathogenesis of PE; therefore, miR-210 could serve as a novel biomarker to predict PE pathophysiology. Further studies are required in this field to characterize the mechanism involved in this process.
BACKGROUND: Pre-eclampsia (PE) is a pregnancy disorder characterized by hypertension and proteinuria. The evidence has suggested that microRNAs (miRs) are associated with pre-eclampsia pathogenesis; however, these results are inconsistent. The aim of this study was to assess the association between miR-210 expression and PE risk. METHODS: Previous studies were selected using PubMed, Scopus, MEDLINE, EMBASE, Science Direct, Google Scholar, Directory of Open Access Journals (DOAJ), and Scientific Information Database (SID). This metaanalysis includes 12 studies associated with miR-210 and pre-eclampsia and necessary information was extracted. RESULTS: The standardized mean differences [(SMD (0.32) 95% CI (014-0.49), p=0.97] and heterogeneity were determined with the chi-square test (Q=3.63 df =11 p= 0.97), which found no heterogeneity between these studies. Additionally, publication bias was evaluated by Egger's and Begg´s tests. Visual inspection of the funnel plot graphically, and statistically with Egger's weighted regression [(p= 0.35) (95% CI -0.90 - 2.29)] and Begg's rank correlation (p= 0.21), found no important publication bias between studies within the meta-analysis. CONCLUSION: Our findings suggest that miR-210 contributes to the pathogenesis of PE; therefore, miR-210 could serve as a novel biomarker to predict PE pathophysiology. Further studies are required in this field to characterize the mechanism involved in this process.
Authors: Lauren Anton; Anthony O Olarerin-George; Nadav Schwartz; Sindhu Srinivas; Jamie Bastek; John B Hogenesch; Michal A Elovitz Journal: Am J Pathol Date: 2013-09-10 Impact factor: 4.307