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Literature DB >> 303227

Alpha-1-antitrypsin phenotypes in a group of newborn infants in Somalia.

Abstract

Pi phenotype determinations were performed on umbilical cord serum specimens of 347 infants born in Mogadishu (Somalia) hospitals. Phenotyping was performed by isoelectric focusing on polyacrylamide gel slabs. Sera containing alpha1AT in types other than MM were also studied by crossed antigen-antibody immunoelectrophoresis on agar. The most frequently occuring Pi allele proved to be PiM. With respect to the other African populations studied so far, there was a high prevalence of the PiS and PiZ alleles. In particular, three individuals were found with the ZZ phenotype, which had not yet been observed in Africa.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
alpha 1-Antitrypsin

Year: 1977 PMID： 303227 DOI： 10.1007/bf00402151

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

13 in total

1. alpha-1 Antitrypsin phenotypes determined by isoelectric focusing of the cysteine-antitrypsin mixed disulfide in serum.

Authors: J A Pierce; J O Jeppsson; C B Laurell
Journal: Anal Biochem Date: 1976-07 Impact factor: 3.365

10. A new method for determination of alpha-1-antitrypsin phenotypes using isoelectric focusing on polyacrylamide gel slabs.

Authors: R C Allen; R A Harley; R C Talamo
Journal: Am J Clin Pathol Date: 1974-12 Impact factor: 2.493

2 in total

1. alpha-1-Protease inhibitor phenotypes and serum concentrations in Thailand.

Authors: P Pongpaew; F P Schelp
Journal: Hum Genet Date: 1980 Impact factor: 4.132

Review 2. Advances in managing COPD related to α₁ -antitrypsin deficiency: An under-recognized genetic disorder.

Authors: Timothy J Craig; Maria Paula Henao
Journal: Allergy Date: 2018-07-26 Impact factor: 13.146

2 in total

Alpha-1-antitrypsin phenotypes in a group of newborn infants in Somalia.

1. alpha-1 Antitrypsin phenotypes determined by isoelectric focusing of the cysteine-antitrypsin mixed disulfide in serum.

2. Alpha-antitrypsin Pi types in postmortem blood.

3. Determination of alpha1-antitrypsin phenotypes by isoelectric focusing in polyacrylamide gels.

4. Antitrypsin phenotypes in St. Louis.

5. Isolation, chemical, and physical properties of alpha-1-antitrypsin.

6. Alpha 1-antitrypsin polymorphism of a Bantu population: description of a new allele PiL.

7. Population genetic studies of serum protein polymorphisms in four Spanish populations. II.

8. Serum Pi types in some European, American, Asian and African populations.

9. Investigations on the population genetics of the alpha-1-antitrypsin polymorphism.

10. A new method for determination of alpha-1-antitrypsin phenotypes using isoelectric focusing on polyacrylamide gel slabs.

1. alpha-1-Protease inhibitor phenotypes and serum concentrations in Thailand.

Review 2. Advances in managing COPD related to α₁ -antitrypsin deficiency: An under-recognized genetic disorder.

Review 2. Advances in managing COPD related to α1 -antitrypsin deficiency: An under-recognized genetic disorder.

Review 2. Advances in managing COPD related to α₁ -antitrypsin deficiency: An under-recognized genetic disorder.