Maria Bygdell1, Jenny M Kindblom1, Jimmy Celind1, Maria Nethander1,2, Claes Ohlsson1. 1. Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine. 2. Bioinformatics Core Facility, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Abstract
Background: An inverse association between childhood body mass index (BMI; in kg/m2) and pubertal timing is well established for girls. Among boys, studies are scarce and the results inconclusive. Objective: We aimed to determine the association between childhood BMI and age at peak height velocity (PHV) in boys. Design: We collected height and weight measurements between 6.5 and 22 y of age for boys born 1945-1961 (original cohort; n = 31,971; mean ± SD childhood BMI: 15.74 ± 1.41; age at PHV: 14.06 ± 1.11 y) and 1981-1996 (replication cohort; n = 1465; childhood BMI: 16.47 ± 2.06; age at PHV: 13.71 ± 1.08 y) attending schools in Gothenburg, Sweden, and examined at mandatory military conscription. Age at PHV was obtained from curve-fitting of measured heights with the use of a modified Infancy-Childhood-Puberty model. Results: In the original cohort, childhood BMI was inversely associated with age at PHV (P < 0.001) and a significant quadratic term for childhood BMI (P < 0.001) indicated the nonlinearity of this association. Via piecewise linear regression, we identified a threshold for the association at a childhood BMI of 18.42. A significant inverse association was observed below (β: -0.17 y/BMI unit; 95% CI: -0.18, -0.16 y/BMI unit) but not above (β: 0.02 y/BMI unit; 95% CI: -0.03, 0.06 y/BMI unit) this childhood BMI threshold. For every unit increase in childhood BMI, age at PHV was ∼2 mo earlier up to the childhood BMI threshold. Similar results were observed in the replication cohort, demonstrating a significant inverse association below (β: -0.16; 95% CI: -0.21, -0.11) but not above (β: -0.03; 95% CI: -0.11, 0.05) the childhood BMI threshold. The identified threshold was close to the cutoffs for overweight at 8 y of age, and childhood BMI was inversely associated with age at PHV below but not above the overweight cutoffs. Conclusions: The present findings establish an inverse association between childhood BMI and pubertal timing in normal-weight but not overweight boys.
Background: An inverse association between childhood body mass index (BMI; in kg/m2) and pubertal timing is well established for girls. Among boys, studies are scarce and the results inconclusive. Objective: We aimed to determine the association between childhood BMI and age at peak height velocity (PHV) in boys. Design: We collected height and weight measurements between 6.5 and 22 y of age for boys born 1945-1961 (original cohort; n = 31,971; mean ± SD childhood BMI: 15.74 ± 1.41; age at PHV: 14.06 ± 1.11 y) and 1981-1996 (replication cohort; n = 1465; childhood BMI: 16.47 ± 2.06; age at PHV: 13.71 ± 1.08 y) attending schools in Gothenburg, Sweden, and examined at mandatory military conscription. Age at PHV was obtained from curve-fitting of measured heights with the use of a modified Infancy-Childhood-Puberty model. Results: In the original cohort, childhood BMI was inversely associated with age at PHV (P < 0.001) and a significant quadratic term for childhood BMI (P < 0.001) indicated the nonlinearity of this association. Via piecewise linear regression, we identified a threshold for the association at a childhood BMI of 18.42. A significant inverse association was observed below (β: -0.17 y/BMI unit; 95% CI: -0.18, -0.16 y/BMI unit) but not above (β: 0.02 y/BMI unit; 95% CI: -0.03, 0.06 y/BMI unit) this childhood BMI threshold. For every unit increase in childhood BMI, age at PHV was ∼2 mo earlier up to the childhood BMI threshold. Similar results were observed in the replication cohort, demonstrating a significant inverse association below (β: -0.16; 95% CI: -0.21, -0.11) but not above (β: -0.03; 95% CI: -0.11, 0.05) the childhood BMI threshold. The identified threshold was close to the cutoffs for overweight at 8 y of age, and childhood BMI was inversely associated with age at PHV below but not above the overweight cutoffs. Conclusions: The present findings establish an inverse association between childhood BMI and pubertal timing in normal-weight but not overweight boys.
Authors: Joyce M Lee; Richard Wasserman; Niko Kaciroti; Achamyeleh Gebremariam; Jennifer Steffes; Steven Dowshen; Donna Harris; Janet Serwint; Dianna Abney; Lynn Smitherman; Edward Reiter; Marcia E Herman-Giddens Journal: Pediatrics Date: 2016-01-27 Impact factor: 7.124
Authors: Susan Y Euling; Marcia E Herman-Giddens; Peter A Lee; Sherry G Selevan; Anders Juul; Thorkild I A Sørensen; Leo Dunkel; John H Himes; Grete Teilmann; Shanna H Swan Journal: Pediatrics Date: 2008-02 Impact factor: 7.124
Authors: Qiao-Li Wang; Mingyang Song; Steven K Clinton; Lorelei A Mucci; Jesper Lagergren; Edward L Giovannucci Journal: Eur J Epidemiol Date: 2022-01-13 Impact factor: 8.082
Authors: Yanhui Li; Di Gao; Jieyu Liu; Zhaogeng Yang; Bo Wen; Li Chen; Manman Chen; Ying Ma; Tao Ma; Bin Dong; Yi Song; Sizhe Huang; Yanhui Dong; Jun Ma Journal: Eur J Clin Nutr Date: 2022-05-06 Impact factor: 4.884