Literature DB >> 30317322

The significance of MGMT methylation in Glioblastoma Multiforme prognosis.

Aaida Mumtaz Rao1, Ayesha Quddusi1, Muhammad Shahzad Shamim1.   

Abstract

Methylation of O6-methylguanine-DNA methyltransferase (MGMT) has been extensively studied as a biomarker in predicting the prognosis of patients with GBM (Glioblastoma multiforme). Its significance has been studied in various subgroups, including age, gender and even race. Correlation between prognosis with MGMT methylation and different treatment regimens has also been studied in detail. There are multiple techniques to analyze MGMT methylation in tumour specimen. We review the current evidence for the importance of MGMT methylation as a biomarker for prognosis in GBM patients, the techniques to analyze it and the effect of epidemiologic factors on its significance.

Entities:  

Keywords:  Glioblastoma multiforme, tumour markers, MGMT methylation..

Mesh：

Substances：

Year:  2018        PMID： 30317322

Source DB:  PubMed          Journal:  J Pak Med Assoc        ISSN： 0030-9982            Impact factor:   0.781


  9 in total

1.  Bevacizumab plus irinotecan with or without gamma knife radiosurgery after failure of concurrent chemo-radiotherapy for high-grade glioma.

Authors:  Yong-Pyo Lee; Hyun Ae Jung; Min-Sang Lee; Jung Won Choi; Doo-Sik Kong; Ho Jun Seol; Do-Hyun Nam; Jung-Il Lee; Se-Hoon Lee
Journal:  J Neurooncol       Date:  2022-01-30       Impact factor: 4.130

Review 2.  Medulloblastoma and the DNA Damage Response.

Authors:  Leon F McSwain; Kiran K Parwani; Shubin W Shahab; Dolores Hambardzumyan; Tobey J MacDonald; Jennifer M Spangle; Anna Marie Kenney
Journal:  Front Oncol       Date:  2022-06-07       Impact factor: 5.738

3.  Study on the mechanism of let-7a-5p in regulating the proliferation in cervical cancer cells.

Authors:  Zhiqin Chen; Jiahui Qiu; Yuling Gao; Qin Lu; Ying Lin; Hong Shi
Journal:  Clin Transl Oncol       Date:  2022-03-18       Impact factor: 3.340

4.  Tim-3 Expression and MGMT Methylation Status Association With Survival in Glioblastoma.

Authors:  Ji Zhang; Ke Sai; Xiao Li Wang; Sheng Quan Ye; Li Jiao Liang; Yi Zhou; Zhi Jie Chen; Wan-Ming Hu; Jian Min Liu
Journal:  Front Pharmacol       Date:  2020-09-15       Impact factor: 5.810

5.  Tumor recurrence or treatment-related changes following chemoradiation in patients with glioblastoma: does pathology predict outcomes?

Authors:  Anthony Patrizz; Antonio Dono; Ping Zhu; Nitin Tandon; Leomar Y Ballester; Yoshua Esquenazi
Journal:  J Neurooncol       Date:  2021-01-22       Impact factor: 4.130

Review 6.  Role of Tumor-Derived Extracellular Vesicles in Glioblastoma.

Authors:  Yunping Chen; Yan Jin; Nan Wu
Journal:  Cells       Date:  2021-02-28       Impact factor: 6.600

7.  Radiomics Analysis Based on Magnetic Resonance Imaging for Preoperative Overall Survival Prediction in Isocitrate Dehydrogenase Wild-Type Glioblastoma.

Authors:  Shouchao Wang; Feng Xiao; Wenbo Sun; Chao Yang; Chao Ma; Yong Huang; Dan Xu; Lanqing Li; Jun Chen; Huan Li; Haibo Xu
Journal:  Front Neurosci       Date:  2022-01-28       Impact factor: 4.677

8.  Exploring the efficacy of tumor electric field therapy against glioblastoma: An in vivo and in vitro study.

Authors:  Hao Wu; Lin Yang; Hanjie Liu; Dan Zhou; Dikang Chen; Xiaoque Zheng; Hui Yang; Chong Li; Jiusheng Chang; Anhua Wu; Zhifei Wang; Nianjun Ren; Shengqing Lv; Yuyang Liu; Muyuan Jia; Jian Lu; Hongyu Liu; Guochen Sun; Zhixiong Liu; Jialin Liu; Ling Chen
Journal:  CNS Neurosci Ther       Date:  2021-10-28       Impact factor: 5.243

Review 9.  Against the Resilience of High-Grade Gliomas: The Immunotherapeutic Approach (Part I).

Authors:  Alice Giotta Lucifero; Sabino Luzzi
Journal:  Brain Sci       Date:  2021-03-18
  9 in total

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