Jaehee Ahn1, Dae Won Jun2, Hyo Young Lee3, Jin Hwa Moon4. 1. Hanyang University College of Medicine, Seoul, South Korea. 2. Department of Internal Medicine, Hanyang University College of Medicine, Seoul, South Korea. Electronic address: noshin@hanyang.ac.kr. 3. Department of Internal Medicine, Hanyang University College of Medicine, Seoul, South Korea. 4. Department of Pediatric Hanyang University College of Medicine, Guri, South Korea.
Abstract
BACKGROUND & AIMS: Weight loss by lifestyle modification is the cornerstone therapy of Non Alcoholic Fatty Liver Disease. Low carbohydrate diet has showed favorable effects for body weight as well as hepatic fat content in several reports. In this meta-analysis, we review clinical studies article to date regarding the composition of the diet and analyzed the impact of low carbohydrate diet comparing to low calorie diet on hepatic fat change, AST and ALT using Forest plot. We aimed to investigate the efficacy of low carbohydrate diet on NAFLD. METHODS: We collected studies that were conducted with various amounts of carbohydrate and different methods for changing the hepatic fat and fibrosis. RESULTS: Eleven clinical studies (seven randomized controlled trials) were selected on the efficacy and safety of low carbohydrate diet on NAFLD patients. Four studies evaluated hepatic fat by magnetic resonance imaging and two evaluated hepatic fat using computed tomography. However, the pools of subjects were small, the criterion for low carbohydrate was variable, and there is yet an established standard method of evaluation of liver. In meta-analysis, there was no significant difference between low carbohydrate diet group and low fat diet group on the improvement of hepatic fat content and transaminases in NAFLD. CONCLUSION: So far there's little evidence that low-carbohydrate diet has more beneficial effect on NAFLD than low calorie diet in similar calorie intake.
BACKGROUND & AIMS:Weight loss by lifestyle modification is the cornerstone therapy of Non Alcoholic Fatty Liver Disease. Low carbohydrate diet has showed favorable effects for body weight as well as hepatic fat content in several reports. In this meta-analysis, we review clinical studies article to date regarding the composition of the diet and analyzed the impact of low carbohydrate diet comparing to low calorie diet on hepatic fat change, AST and ALT using Forest plot. We aimed to investigate the efficacy of low carbohydrate diet on NAFLD. METHODS: We collected studies that were conducted with various amounts of carbohydrate and different methods for changing the hepatic fat and fibrosis. RESULTS: Eleven clinical studies (seven randomized controlled trials) were selected on the efficacy and safety of low carbohydrate diet on NAFLD patients. Four studies evaluated hepatic fat by magnetic resonance imaging and two evaluated hepatic fat using computed tomography. However, the pools of subjects were small, the criterion for low carbohydrate was variable, and there is yet an established standard method of evaluation of liver. In meta-analysis, there was no significant difference between low carbohydrate diet group and low fat diet group on the improvement of hepatic fat content and transaminases in NAFLD. CONCLUSION: So far there's little evidence that low-carbohydrate diet has more beneficial effect on NAFLD than low calorie diet in similar calorie intake.
Authors: Athina I Amanatidou; Andriana C Kaliora; Charalampia Amerikanou; Stefan Stojanoski; Natasa Milosevic; Chara Vezou; Mirjana Beribaka; Rajarshi Banerjee; Ioanna-Panagiota Kalafati; Ilias Smyrnioudis; Mary Jo Kurth; Aimo Kannt; M Pilar Francino; Sophie Visvikis-Siest; Panos Deloukas; Carlos Llorens; Fernando Marascio; Natasa Milic; Milica Medic-Stojanoska; Amalia Gastaldelli; Maria Giovanna Trivella; George V Dedoussis Journal: Int J Environ Res Public Health Date: 2022-01-16 Impact factor: 3.390