Susan E Levy1, Jennifer A Pinto-Martin2, Chyrise B Bradley3, Jesse Chittams4, Susan L Johnson5, Juhi Pandey6, Alison Pomykacz6, AnnJosette Ramirez7, Ann Reynolds8, Eric Rubenstein9, Laura A Schieve10, Stuart K Shapira10, Aleda Thompson4, Lisa Young2, Tanja V E Kral2. 1. Center for Autism Research, Children's Hospital of Philadelphia, Philadelphia, PA; Department of Pediatrics, University of Pennsylvania, Philadelphia, PA. 2. Department of Biobehavioral Health Sciences, School of Nursing at University of Pennsylvania, Philadelphia, PA. 3. Department of Epidemiology, Gillings School of Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC. 4. Office of Nursing Research, School of Nursing at University of Pennsylvania, Philadelphia, PA. 5. Section of Nutrition/Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO. 6. Center for Autism Research, Children's Hospital of Philadelphia, Philadelphia, PA. 7. Department of Epidemiology, Thomas Jefferson University, Philadelphia, PA. 8. Department of Pediatrics at the University of Colorado School of Medicine, Aurora, CO. 9. Waisman Center and the University of Wisconsin-Madison, Madison, WI. 10. National Center Birth Defects and Developmental Disability, Centers for Disease Control and Prevention, Atlanta, GA.
Abstract
OBJECTIVE: To assess contributing factors to increased obesity risk, by comparing children with autism spectrum disorder (ASD), developmental delays/disorders, and general population controls in weight status, and to examine associations between weight status and presence of co-occurring medical, behavioral, developmental, or psychiatric conditions across groups and ASD severity among children with ASD. STUDY DESIGN: The Study to Explore Early Development is a multisite cross-sectional study of children, 2-5 years of age, classified as children with ASD (n = 668), children with developmental delays/disorders (n = 914), or general population controls (n = 884). Using an observational cohort design, we compared the 3 groups. Children's heights and weights were measured during a clinical visit. Co-occurring conditions (medical, behavioral, developmental/psychiatric) were derived from medical records, interviews, and questionnaires. ASD severity was measured by the Ohio State University Global Severity Scale for Autism. RESULTS: The odds of overweight/obesity were 1.57 times (95% CI 1.24-2.00) higher in children with ASD than general population controls and 1.38 times (95% CI 1.10-1.72) higher in children with developmental delays/disorders than general population controls. The aORs were elevated for children with ASD after controlling for child co-occurring conditions (ASD vs general population controls: aOR = 1.51; 95% CI 1.14-2.00). Among children with ASD, those with severe ASD symptoms were 1.7 times (95% CI 1.1-2.8) more likely to be classified as overweight/obese compared with children with mild ASD symptoms. CONCLUSIONS: Prevention of excess weight gain in children with ASD, especially those with severe symptoms, and in children with developmental delays/disorders represents an important target for intervention.
OBJECTIVE: To assess contributing factors to increased obesity risk, by comparing children with autism spectrum disorder (ASD), developmental delays/disorders, and general population controls in weight status, and to examine associations between weight status and presence of co-occurring medical, behavioral, developmental, or psychiatric conditions across groups and ASD severity among children with ASD. STUDY DESIGN: The Study to Explore Early Development is a multisite cross-sectional study of children, 2-5 years of age, classified as children with ASD (n = 668), children with developmental delays/disorders (n = 914), or general population controls (n = 884). Using an observational cohort design, we compared the 3 groups. Children's heights and weights were measured during a clinical visit. Co-occurring conditions (medical, behavioral, developmental/psychiatric) were derived from medical records, interviews, and questionnaires. ASD severity was measured by the Ohio State University Global Severity Scale for Autism. RESULTS: The odds of overweight/obesity were 1.57 times (95% CI 1.24-2.00) higher in children with ASD than general population controls and 1.38 times (95% CI 1.10-1.72) higher in children with developmental delays/disorders than general population controls. The aORs were elevated for children with ASD after controlling for child co-occurring conditions (ASD vs general population controls: aOR = 1.51; 95% CI 1.14-2.00). Among children with ASD, those with severe ASD symptoms were 1.7 times (95% CI 1.1-2.8) more likely to be classified as overweight/obese compared with children with mild ASD symptoms. CONCLUSIONS: Prevention of excess weight gain in children with ASD, especially those with severe symptoms, and in children with developmental delays/disorders represents an important target for intervention.
Authors: Kristie L Hubbard; Sarah E Anderson; Carol Curtin; Aviva Must; Linda G Bandini Journal: J Acad Nutr Diet Date: 2014-06-11 Impact factor: 4.910
Authors: Lisa D Wiggins; Ann Reynolds; Catherine E Rice; Eric J Moody; Pilar Bernal; Lisa Blaskey; Steven A Rosenberg; Li-Ching Lee; Susan E Levy Journal: J Autism Dev Disord Date: 2015-05
Authors: E Whitney Evans; Aviva Must; Sarah E Anderson; Carol Curtin; Renee Scampini; Melissa Maslin; Linda Bandini Journal: Res Autism Spectr Disord Date: 2012
Authors: Diana E Schendel; Carolyn Diguiseppi; Lisa A Croen; M Daniele Fallin; Philip L Reed; Laura A Schieve; Lisa D Wiggins; Julie Daniels; Judith Grether; Susan E Levy; Lisa Miller; Craig Newschaffer; Jennifer Pinto-Martin; Cordelia Robinson; Gayle C Windham; Aimee Alexander; Arthur S Aylsworth; Pilar Bernal; Joseph D Bonner; Lisa Blaskey; Chyrise Bradley; Jack Collins; Casara J Ferretti; Homayoon Farzadegan; Ellen Giarelli; Marques Harvey; Susan Hepburn; Matthew Herr; Kristina Kaparich; Rebecca Landa; Li-Ching Lee; Brooke Levenseller; Stacey Meyerer; Mohammad H Rahbar; Andria Ratchford; Ann Reynolds; Steven Rosenberg; Julie Rusyniak; Stuart K Shapira; Karen Smith; Margaret Souders; Patrick Aaron Thompson; Lisa Young; Marshalyn Yeargin-Allsopp Journal: J Autism Dev Disord Date: 2012-10