Christopher S Lee1, Quin E Denfeld2, Bradley E Aouizerat3, Corrine Y Jurgens4, Christopher V Chien5, Emily Aarons6, Jill M Gelow7, Shirin O Hiatt8, James O Mudd9. 1. Professor and Associate Dean for Research, Boston College William F. Connell School of Nursing, 140 Commonwealth Avenue, Maloney Hall 226, Chestnut Hill, MA, United States. Electronic address: christopher.lee.8@bc.edu. 2. Oregon Health & Science School of Nursing, Portland, OR, United States. 3. New York University Department of Oral and Maxillofacial Surgery, New York, NY, United States. 4. Stony Brook University School of Nursing, Stony Brook, NY, United States. 5. University of North Carolina REX Healthcare, Raleigh, NC, United States. 6. Boston College William F. Connell School of Nursing, Chestnut Hill, MA, United States. 7. Providence Health, Portland, OR, United States. 8. Oregon Health & Science University School of Nursing, Portland, OR, United States. 9. Oregon Health & Science University Knight Cardiovascular Institute, Portland, OR, United States.
Abstract
BACKGROUND: We have a limited understanding of the biological underpinnings of symptoms in heart failure (HF). OBJECTIVES: The purpose of this paper was to compare relationships between peripheral biomarkers of HF pathogenesis and physical symptoms between patients with advanced versus moderate HF. METHODS: This was a two-stage phenotype sampling cohort study wherein we examined patients with advanced HF undergoing ventricular assist device implantation in the first stage, and then patients with moderate HF (matched adults with HF not requiring device implantation) in the second stage. Linear modeling was used to compare relationships among biomarkers and physical symptoms between cohorts. RESULTS: Worse myocardial stress, systemic inflammation and endothelial dysfunction were associated with worse physical symptoms in moderate HF (n=48), but less physical symptom burden in advanced HF (n=48). CONCLUSIONS: Where patients are in the HF trajectory needs to be taken into consideration when exploring biological underpinnings of physical HF symptoms.
BACKGROUND: We have a limited understanding of the biological underpinnings of symptoms in heart failure (HF). OBJECTIVES: The purpose of this paper was to compare relationships between peripheral biomarkers of HF pathogenesis and physical symptoms between patients with advanced versus moderate HF. METHODS: This was a two-stage phenotype sampling cohort study wherein we examined patients with advanced HF undergoing ventricular assist device implantation in the first stage, and then patients with moderate HF (matched adults with HF not requiring device implantation) in the second stage. Linear modeling was used to compare relationships among biomarkers and physical symptoms between cohorts. RESULTS: Worse myocardial stress, systemic inflammation and endothelial dysfunction were associated with worse physical symptoms in moderate HF (n=48), but less physical symptom burden in advanced HF (n=48). CONCLUSIONS: Where patients are in the HF trajectory needs to be taken into consideration when exploring biological underpinnings of physical HF symptoms.
Authors: Evgenij V Potapov; Felix Hennig; Frank D Wagner; Hans-Dieter Volk; Ralf Sodian; Harald Hausmann; Hans B Lehmkuhl; Roland Hetzer Journal: Eur J Cardiothorac Surg Date: 2005-05 Impact factor: 4.191
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Authors: Kirkwood F Adams; Gregg C Fonarow; Charles L Emerman; Thierry H LeJemtel; Maria Rosa Costanzo; William T Abraham; Robert L Berkowitz; Marie Galvao; Darlene P Horton Journal: Am Heart J Date: 2005-02 Impact factor: 4.749
Authors: M Rauchhaus; W Doehner; D P Francis; C Davos; M Kemp; C Liebenthal; J Niebauer; J Hooper; H D Volk; A J Coats; S D Anker Journal: Circulation Date: 2000-12-19 Impact factor: 29.690
Authors: Kenneth M Faulkner; Corrine Y Jurgens; Quin E Denfeld; Karen S Lyons; Jessica Harman Thompson; Christopher S Lee Journal: Heart Lung Date: 2020-05-18 Impact factor: 2.210
Authors: Quin E Denfeld; Kenneth M Faulkner; Mary Roberts Davis; Beth A Habecker; Christopher V Chien; Jill M Gelow; James O Mudd; Shirin O Hiatt; Kathleen L Grady; Christopher S Lee Journal: Eur J Cardiovasc Nurs Date: 2021-10-27 Impact factor: 3.593