Literature DB >> 30311932

Hyperpolarized fumarate via parahydrogen.

Barbara Ripka1, James Eills2, Hana Kouřilová2, Markus Leutzsch3, Malcolm H Levitt2, Kerstin Münnemann4.   

Abstract

We produce hyperpolarized [1-13C]fumarate in the proton nuclear spin singlet state by pairwise trans-addition of parahydrogen to a molecular precursor using a ruthenium-based catalyst in water. The proton singlet state is transformed into observable carbon magnetization by radiofrequency pulses to enhance the 13C signal by a factor of 1000 using 50% para-enriched hydrogen gas.

Entities:  

Year:  2018        PMID： 30311932     DOI： 10.1039/c8cc06636a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  11 in total

1.  Instrumentation for Hydrogenative Parahydrogen-Based Hyperpolarization Techniques.

Authors:  Andreas B Schmidt; C Russell Bowers; Kai Buckenmaier; Eduard Y Chekmenev; Henri de Maissin; James Eills; Frowin Ellermann; Stefan Glöggler; Jeremy W Gordon; Stephan Knecht; Igor V Koptyug; Jule Kuhn; Andrey N Pravdivtsev; Francesca Reineri; Thomas Theis; Kolja Them; Jan-Bernd Hövener
Journal:  Anal Chem       Date:  2022-01-01       Impact factor: 6.986

Review 2.  Advancing homogeneous catalysis for parahydrogen-derived hyperpolarisation and its NMR applications.

Authors:  Ben J Tickner; Vladimir V Zhivonitko
Journal:  Chem Sci       Date:  2022-03-22       Impact factor: 9.969

3.  Heterogeneous 1 H and 13 C Parahydrogen-Induced Polarization of Acetate and Pyruvate Esters.

Authors:  Oleg G Salnikov; Nikita V Chukanov; Larisa M Kovtunova; Valerii I Bukhtiyarov; Kirill V Kovtunov; Roman V Shchepin; Igor V Koptyug; Eduard Y Chekmenev
Journal:  Chemphyschem       Date:  2021-05-28       Impact factor: 3.520

4.  In-vitro NMR Studies of Prostate Tumor Cell Metabolism by Means of Hyperpolarized [1-13C]Pyruvate Obtained Using the PHIP-SAH Method.

Authors:  Eleonora Cavallari; Carla Carrera; Ginevra Di Matteo; Oksana Bondar; Silvio Aime; Francesca Reineri
Journal:  Front Oncol       Date:  2020-04-17       Impact factor: 6.244

Review 5.  Hydrogenative-PHIP polarized metabolites for biological studies.

Authors:  Francesca Reineri; Eleonora Cavallari; Carla Carrera; Silvio Aime
Journal:  MAGMA       Date:  2021-02-02       Impact factor: 2.310

6.  Rapid hyperpolarization and purification of the metabolite fumarate in aqueous solution.

Authors:  Stephan Knecht; John W Blanchard; Danila Barskiy; Eleonora Cavallari; Laurynas Dagys; Erik Van Dyke; Maksim Tsukanov; Bea Bliemel; Kerstin Münnemann; Silvio Aime; Francesca Reineri; Malcolm H Levitt; Gerd Buntkowsky; Alexander Pines; Peter Blümler; Dmitry Budker; James Eills
Journal:  Proc Natl Acad Sci U S A       Date:  2021-03-30       Impact factor: 11.205

7.  Singlet-Contrast Magnetic Resonance Imaging: Unlocking Hyperpolarization with Metabolism*.

Authors:  J Eills; E Cavallari; R Kircher; G Di Matteo; C Carrera; L Dagys; M H Levitt; K L Ivanov; S Aime; F Reineri; K Münnemann; D Budker; G Buntkowsky; S Knecht
Journal:  Angew Chem Int Ed Engl       Date:  2021-02-11       Impact factor: 15.336

8.  Direct Production of a Hyperpolarized Metabolite on a Microfluidic Chip.

Authors:  Sylwia J Barker; Laurynas Dagys; William Hale; Barbara Ripka; James Eills; Manvendra Sharma; Malcolm H Levitt; Marcel Utz
Journal:  Anal Chem       Date:  2022-02-11       Impact factor: 8.008

Review 9.  Recent advances in the application of parahydrogen in catalysis and biochemistry.

Authors:  Gerd Buntkowsky; Franziska Theiss; Jonas Lins; Yuliya A Miloslavina; Laura Wienands; Alexey Kiryutin; Alexandra Yurkovskaya
Journal:  RSC Adv       Date:  2022-04-26       Impact factor: 4.036

Review 10.  Biomedical Applications of the Dynamic Nuclear Polarization and Parahydrogen Induced Polarization Techniques for Hyperpolarized 13C MR Imaging.

Authors:  Neil J Stewart; Shingo Matsumoto
Journal:  Magn Reson Med Sci       Date:  2019-12-27       Impact factor: 2.471
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