Literature DB >> 30311860

Human Tissue-Engineered Model of Myocardial Ischemia-Reperfusion Injury.

Timothy Chen1, Gordana Vunjak-Novakovic1,2.   

Abstract

IMPACT STATEMENT: Reducing ischemia-reperfusion injury would significantly improve patient survival. Current preclinical models are inadequate because they rely on animals, which do not emulate human physiology and the clinical setting. We developed a human tissue platform that allowed us to assess the human cardiac response, and demonstrated the platform's utility by measuring injury during ischemia-reperfusion and the effects of cardioprotective strategies. The model provides a foundation for future studies on how patient-specific backgrounds may affect response to therapeutic strategies. These steps will be necessary to help translate therapies into the clinical setting.

Entities:  

Keywords:  bioreactor; cardioprotection; disease modeling; human cardiac tissue; myocardium

Mesh：

Year:  2018        PMID： 30311860      PMCID： PMC6535981          DOI： 10.1089/ten.TEA.2018.0212

Source DB:  PubMed          Journal:  Tissue Eng Part A        ISSN： 1937-3341            Impact factor:   3.845


  91 in total

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  15 in total

Review 1.  Human pluripotent stem cell-derived cardiac stromal cells and their applications in regenerative medicine.

Authors:  Martha E Floy; Taylor D Mateyka; Koji L Foreman; Sean P Palecek
Journal:  Stem Cell Res       Date:  2020-04-27       Impact factor: 2.020

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Authors:  Gozde Basara; Gokhan Bahcecioglu; S Gulberk Ozcebe; Bradley W Ellis; George Ronan; Pinar Zorlutuna
Journal:  Biophys Rev (Melville)       Date:  2022-08-30

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Journal:  Nat Biomed Eng       Date:  2020-04-13       Impact factor: 25.671

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Journal:  ACS Biomater Sci Eng       Date:  2019-10-29

Review 5.  Harnessing organs-on-a-chip to model tissue regeneration.

Authors:  Daniel Naveed Tavakol; Sharon Fleischer; Gordana Vunjak-Novakovic
Journal:  Cell Stem Cell       Date:  2021-06-03       Impact factor: 25.269

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Authors:  Karl T Wagner; Trevor R Nash; Bohao Liu; Gordana Vunjak-Novakovic; Milica Radisic
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Authors:  Jack F Murphy; Joshua Mayourian; Francesca Stillitano; Sadek Munawar; Kathleen M Broughton; Esperanza Agullo-Pascual; Mark A Sussman; Roger J Hajjar; Kevin D Costa; Irene C Turnbull
Journal:  Stem Cell Res Ther       Date:  2019-12-04       Impact factor: 6.832

Review 8.  Human Cell Modeling for Cardiovascular Diseases.

Authors:  Melania Lippi; Ilaria Stadiotti; Giulio Pompilio; Elena Sommariva
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Authors:  Clara Liu Chung Ming; Kimberly Sesperez; Eitan Ben-Sefer; David Arpon; Kristine McGrath; Lana McClements; Carmine Gentile
Journal:  Cells       Date:  2021-04-14       Impact factor: 6.600

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Authors:  Sandra Funcke; Tessa R Werner; Marc Hein; Bärbel M Ulmer; Arne Hansen; Thomas Eschenhagen; Marc N Hirt
Journal:  Biomolecules       Date:  2020-09-11
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