Literature DB >> 3030805

Biologically significant scavenging of the myeloperoxidase-derived oxidant hypochlorous acid by ascorbic acid. Implications for antioxidant protection in the inflamed rheumatoid joint.

B Halliwell, M Wasil, M Grootveld.   

Abstract

Ascorbic acid, at physiological concentrations, can scavenge the myeloperoxidase-derived oxidant hypochlorous acid at rates sufficient to protect alpha 1-antiprotease against inactivation by this molecule. The rapid depletion of ascorbic acid at sites of inflammation, as in the inflamed rheumatoid joint, may therefore facilitate proteolytic damage.

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Year:  1987        PMID： 3030805     DOI： 10.1016/0014-5793(87)81456-4

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  25 in total

1.  Action of hypochlorous acid on the antioxidant protective enzymes superoxide dismutase, catalase and glutathione peroxidase.

Authors:  O I Aruoma; B Halliwell
Journal:  Biochem J       Date:  1987-12-15       Impact factor: 3.857

2.  Enhanced erythrocytic lipid peroxides and reduced plasma ascorbic acid, and alteration in blood trace elements level in dairy cows with mastitis.

Authors:  R Ranjan; D Swarup; R Naresh; R C Patra
Journal:  Vet Res Commun       Date:  2005-01       Impact factor: 2.459

3.  Antioxidant activity and low cytotoxicity of extracts and isolated compounds from Araucaria angustifolia dead bark.

Authors:  Andrea Seccon; Daniela W Rosa; Rilton A Freitas; Maique W Biavatti; Tania B Creczynski-Pasa
Journal:  Redox Rep       Date:  2010       Impact factor: 4.412

4.  Role of gastric mucosal ascorbic acid in gastric mucosal lesion development in rats with water immersion restraint stress.

Authors:  Yoshiji Ohta; Yoshio Kamiya; Yoichiro Imai; Tomiyasu Arisawa; Hiroshi Nakano
Journal:  Inflammopharmacology       Date:  2005       Impact factor: 4.473

5.  2nd International meeting on synovium cell biology, physiology and pathology. Canterbury, United Kingdom, 21-23 September 1994. Proceedings and abstracts.

Authors: 
Journal:  Ann Rheum Dis       Date:  1995-06       Impact factor: 19.103

Review 6.  Oxygen radicals, nitric oxide and human inflammatory joint disease.

Authors:  B Halliwell
Journal:  Ann Rheum Dis       Date:  1995-06       Impact factor: 19.103

7.  Inhibition of hypochlorous acid-induced cellular toxicity by nitrite.

Authors:  Matthew Whiteman; D Craig Hooper; Gwen S Scott; Hilary Koprowski; Barry Halliwell
Journal:  Proc Natl Acad Sci U S A       Date:  2002-09-09       Impact factor: 11.205

8.  Reduction of the surface-tension-lowering ability of surfactant after exposure to hypochlorous acid.

Authors:  T A Merritt; J D Amirkhanian; H Helbock; B Halliwell; C E Cross
Journal:  Biochem J       Date:  1993-10-01       Impact factor: 3.857

9.  Purification of NADPH-dependent dehydroascorbate reductase from rat liver and its identification with 3 alpha-hydroxysteroid dehydrogenase.

Authors:  B Del Bello; E Maellaro; L Sugherini; A Santucci; M Comporti; A F Casini
Journal:  Biochem J       Date:  1994-12-01       Impact factor: 3.857

10.  Oxidation of low-density lipoprotein with hypochlorite causes transformation of the lipoprotein into a high-uptake form for macrophages.

Authors:  L J Hazell; R Stocker
Journal:  Biochem J       Date:  1993-02-15       Impact factor: 3.857
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