Literature DB >> 16259744

Role of gastric mucosal ascorbic acid in gastric mucosal lesion development in rats with water immersion restraint stress.

Yoshiji Ohta1, Yoshio Kamiya, Yoichiro Imai, Tomiyasu Arisawa, Hiroshi Nakano.   

Abstract

We examined the role of gastric mucosal ascorbic acid (AA) in gastric mucosal lesion development in rats with water immersion restraint stress (WIRS). When fasted rats were subjected to WIRS for 1, 3 or 6 h, gastric mucosal lesions developed at 3 and 6 h. Gastric mucosal AA concentration decreased at 3 and 6 h after the onset of WIRS, while gastric mucosal non-protein SH concentration decreased at 1, 3, and 6 h and gastric mucosal vitamin E concentration decreased at 6 h. Gastric mucosal lipid peroxide concentration and myeloperoxidase activity increased at 3 and 6 h of WIRS. Pre-administration of AA (250 mg/kg) prevented gastric mucosal development with attenuation of the decreased gastric mucosal AA, non-protein SH and vitamin E concentrations, and the increased gastric mucosal lipid peroxide concentration and myeloperoxidase activity. These results suggest that gastric mucosal AA plays an important role in WIRS-induced gastric mucosal lesion development.

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Year:  2005        PMID： 16259744     DOI： 10.1163/156856005774423881

Source DB:  PubMed          Journal:  Inflammopharmacology        ISSN： 0925-4692            Impact factor:   4.473


  38 in total

1.  The role of lipid peroxidation on gastric mucosal lesions induced by water-immersion-restraint stress in rats.

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Journal:  Biochim Biophys Acta       Date:  1987-09-11

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Journal:  Science       Date:  1979-09-07       Impact factor: 47.728

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Journal:  Intensive Care Med       Date:  1991       Impact factor: 17.440

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Journal:  FEBS Lett       Date:  1984-12-03       Impact factor: 4.124

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Journal:  Gastroenterology       Date:  1984-12       Impact factor: 22.682

9.  Relation of inducible nitric oxide synthase activity to lipid peroxidation and nonprotein sulfhydryl oxidation in the development of stress-induced gastric mucosal lesions in rats.

Authors:  K Nishida; Y Ohta; I Ishiguro
Journal:  Nitric Oxide       Date:  1998       Impact factor: 4.427

10.  Gastric mucosal phosphatidylcholine hydroperoxide increases during cold water-immersion restraint stress in rats.

Authors:  W M Shian; I Sasaki; Y Kamiyama; H Naito; Y Funayama; S Matsuno; T Miyazawa
Journal:  Tohoku J Exp Med       Date:  1995-06       Impact factor: 1.848
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  7 in total

1.  Protective effect of L-ascorbic acid against oxidative damage in the liver of rats with water-immersion restraint stress.

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Journal:  Redox Rep       Date:  2010       Impact factor: 4.412

2.  A single exposure of rats to water-immersion restraint stress induces oxidative stress more severely in the thymus than in the spleen.

Authors:  Yoshiji Ohta; Koji Yashiro; Mayumi Hidaka; Minako Honda; Yoichoro Imai; Koji Ohashi; Kenji Fukuzawa
Journal:  Redox Rep       Date:  2012       Impact factor: 4.412

3.  Palm vitamin E reduces catecholamines, xanthine oxidase activity and gastric lesions in rats exposed to water-immersion restraint stress.

Authors:  Nur Azlina Mohd Fahami; Ibrahim Abdelaziz Ibrahim; Yusof Kamisah; Nafeeza Mohd Ismail
Journal:  BMC Gastroenterol       Date:  2012-05-28       Impact factor: 3.067

4.  The effects of palm vitamin E on stress hormone levels and gastric lesions in stress-induced rats.

Authors:  Ibrahim Abdel Aziz Ibrahim; Yusof Kamisah; Mohd Ismail Nafeeza; Mohd Fahami Nur Azlina
Journal:  Arch Med Sci       Date:  2012-02-29       Impact factor: 3.318

5.  Protective Effect of Repeatedly Preadministered Brazilian Propolis Ethanol Extract against Stress-Induced Gastric Mucosal Lesions in Rats.

Authors:  Tadashi Nakamura; Yoshiji Ohta; Kumiko Ikeno; Koji Ohashi; Takeyuki Ikeno
Journal:  Evid Based Complement Alternat Med       Date:  2014-02-03       Impact factor: 2.629

6.  Disruption of non-enzymatic antioxidant defense systems in the brain of rats with water-immersion restraint stress.

Authors:  Yoshiji Ohta; Koji Yashiro; Koji Ohashi; Yoichiro Imai
Journal:  J Clin Biochem Nutr       Date:  2012-06-08       Impact factor: 3.114

7.  Acute Cold Water-Immersion Restraint Stress Induces Intestinal Injury and Reduces the Diversity of Gut Microbiota in Mice.

Authors:  Yuan Zhang; Shuwen Wu; Yongming Liu; Jingchang Ma; Wenpeng Li; Xuexue Xu; Yuling Wang; Yanling Luo; Kun Cheng; Ran Zhuang
Journal:  Front Cell Infect Microbiol       Date:  2021-10-14       Impact factor: 5.293
  7 in total

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