Noriyuki Fujima1, Kenji Hirata2, Tohru Shiga2, Koichi Yasuda3,4, Rikiya Onimaru3, Kazuhiko Tsuchiya5, Satoshi Kano6, Takatsugu Mizumachi6, Akihiro Homma6, Kohsuke Kudo1, Hiroki Shirato3,4. 1. Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan. 2. Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan. 3. Department of Radiation Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan. 4. The Global Station for Quantum Medical Science and Engineering, Global Institution for Collaborative Research and Education, Sapporo, Japan. 5. Department of Radiation Oncology, Otaru General Hospital, Otaru, Japan. 6. Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Abstract
BACKGROUND: To investigate the utility of quantitative morphological and intratumoral characteristics obtained by 18F-fluorodeoxyglucose positron-emission tomography/computed tomography (FDG-PET/CT) for the prediction of treatment outcome in patients with nasal or paranasal cavity squamous cell carcinoma (SCC). METHODS: Twenty-four patients with nasal or paranasal cavity SCC who received curative non-surgical therapy (a combination of super-selective arterial cisplatin infusion and radiotherapy) were retrospectively analyzed. From pre-treatment FDG-PET data, a total of 13 parameters of quantitative morphological characteristics (tumor volume, surface area and sphericity), intratumoral characteristics (the maximum and mean standard uptake value, three intratumoral histogram and four textural parameters) and total lesion glycolysis (TLG) were respectively calculated. Information regarding the treatment outcome was determined from the histological diagnosis or clinical follow-up. Each of the 13 quantitative parameters as well as T- and N-stage was assessed for its relation to treatment outcome of local control or failure. RESULTS: In univariate analysis, significant differences in surface area and sphericity between the local control and failure groups were observed. The receiver operating characteristic (ROC) curve analysis showed that sphericity had the highest accuracy of 0.88. In the multivariate analysis, sphericity was revealed as an independent predictor of the local control or failure. CONCLUSIONS: The quantitative parameters of sphericity are useful to predict the treatment outcome in patients with nasal or paranasal SCC.
BACKGROUND: To investigate the utility of quantitative morphological and intratumoral characteristics obtained by 18F-fluorodeoxyglucose positron-emission tomography/computed tomography (FDG-PET/CT) for the prediction of treatment outcome in patients with nasal or paranasal cavity squamous cell carcinoma (SCC). METHODS: Twenty-four patients with nasal or paranasal cavity SCC who received curative non-surgical therapy (a combination of super-selective arterial cisplatin infusion and radiotherapy) were retrospectively analyzed. From pre-treatment FDG-PET data, a total of 13 parameters of quantitative morphological characteristics (tumor volume, surface area and sphericity), intratumoral characteristics (the maximum and mean standard uptake value, three intratumoral histogram and four textural parameters) and total lesion glycolysis (TLG) were respectively calculated. Information regarding the treatment outcome was determined from the histological diagnosis or clinical follow-up. Each of the 13 quantitative parameters as well as T- and N-stage was assessed for its relation to treatment outcome of local control or failure. RESULTS: In univariate analysis, significant differences in surface area and sphericity between the local control and failure groups were observed. The receiver operating characteristic (ROC) curve analysis showed that sphericity had the highest accuracy of 0.88. In the multivariate analysis, sphericity was revealed as an independent predictor of the local control or failure. CONCLUSIONS: The quantitative parameters of sphericity are useful to predict the treatment outcome in patients with nasal or paranasal SCC.
Entities:
Keywords:
Head and neck neoplasms; carcinoma, squamous cell; positron-emission tomography
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