Literature DB >> 3030485

Crystal-induced inflammation in the rat subcutaneous air-pouch.

P M Brooks, D Burton, M J Forrest.   

Abstract

Monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD) crystals initiated acute inflammatory reactions characterized by increased plasma extravasation and polymorphonuclear leukocyte (PMNL) accumulation in the rat subcutaneous air-pouch. Pretreatment of rats with colchicine (1 mg kg-1, s.c.) inhibited PMNL accumulation induced by either crystal type but had a greater inhibitory effect on MSU-induced plasma extravasation compared with that induced by CPPD crystals. Colchicine (1 mg kg-1, s.c.) did not reduce histamine-induced plasma extravasation in the air-pouch. The lipoxygenase product of arachidonic acid metabolism, leukotriene B4 (LTB4), was detected in MSU-induced exudates but not in CPPD-induced exudates. Pretreatment of rats with colchicine (1 mg kg-1, s.c.) inhibited LTB4 production in MSU-induced exudates.

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Year:  1987        PMID： 3030485      PMCID： PMC1916951          DOI： 10.1111/j.1476-5381.1987.tb08971.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  21 in total

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Authors:  N N KOHN; R E HUGHES; D J McCARTY; J S FAIRES
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2.  Crystal-induced inflammation, enzyme release and the effects of drugs in the rat pleural space.

Authors:  M Glatt; P Dieppe; D Willoughby
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3.  Leukotriene B: a potential mediator of inflammation.

Authors:  M J Smith; A W Ford-Hutchinson; M A Bray
Journal:  J Pharm Pharmacol       Date:  1980-07       Impact factor: 3.765

4.  Control of vascular permeability by polymorphonuclear leukocytes in inflammation.

Authors:  C V Wedmore; T J Williams
Journal:  Nature       Date:  1981-02-19       Impact factor: 49.962

5.  The formation of a structure with the features of synovial lining by subcutaneous injection of air: an in vivo tissue culture system.

Authors:  J C Edwards; A D Sedgwick; D A Willoughby
Journal:  J Pathol       Date:  1981-06       Impact factor: 7.996

6.  Transformation of arachidonic acid and homo-gamma-linolenic acid by rabbit polymorphonuclear leukocytes. Monohydroxy acids from novel lipoxygenases.

Authors:  P Borgeat; M Hamberg; B Samuelsson
Journal:  J Biol Chem       Date:  1976-12-25       Impact factor: 5.157

7.  Chemokinetic activity of arachidonic and lipoxygenase products on leuocyctes of different species.

Authors:  R M Palmer; R J Stepney; G A Higgs; K E Eakins
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8.  Experimental inflammation induced by naturally occurring microcrystalline calcium salts.

Authors:  C W Denko; M W Whitehouse
Journal:  J Rheumatol       Date:  1976-03       Impact factor: 4.666

9.  The human PMN leukocyte chemotactic activity of complex hydroxy-eicosatetraenoic acids (HETEs).

Authors:  E J Goetzl; W C Pickett
Journal:  J Immunol       Date:  1980-10       Impact factor: 5.422

10.  Crystal-induced inflammation in canine joints. I. An experimental model with quantification of the host response.

Authors:  D J McCarty; P Phelps; J Pyenson
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  7 in total

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4.  Inhibition of leucotriene B4 synthesis by BW 755c does not reduce polymorphonuclear leucocyte (PMNL) accumulation induced by monosodium urate crystals.

Authors:  M J Forrest; V Zammit; P M Brooks
Journal:  Ann Rheum Dis       Date:  1988-03       Impact factor: 19.103

5.  Effects of Colchicine on Atherosclerotic Plaque Stabilization: a Multimodality Imaging Study in an Animal Model.

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6.  Omega-3-carboxylic acids provide efficacious anti-inflammatory activity in models of crystal-mediated inflammation.

Authors:  Cory Iverson; Andrew Bacong; Sha Liu; Scott Baumgartner; Torbjörn Lundström; Jan Oscarsson; Jeffrey N Miner
Journal:  Sci Rep       Date:  2018-01-19       Impact factor: 4.379

7.  Joint nociceptor nerve activity and pain in an animal model of acute gout and its modulation by intra-articular hyaluronan.

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  7 in total

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