Literature DB >> 3030322

Drug metabolism by the human hepatoma cell, Hep G2.

S Sassa, O Sugita, R A Galbraith, A Kappas.   

Abstract

The human liver-derived cell line, Hep G2, has aryl hydrocarbon hydroxylase and 7-ethoxycoumarin o-de-ethylase activities. Partial purification of cytochrome P-450 from Hep G2 cells provided spectral evidence of this hemeprotein in the purified fraction. These results suggest that Hep G2 cells will be useful for the study of cytochrome P-450 and the regulation of mixed function oxidase activities in liver cells of human origin.

Entities:  

Mesh：

Substances：

Year:  1987        PMID： 3030322     DOI： 10.1016/0006-291x(87)90628-0

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  27 in total

1.  Use of established hepatoma cell lines in biotoxicology.

Authors:  M Ferro; A M Bassi; S Penco; G Nanni
Journal:  Cytotechnology       Date:  1993-01       Impact factor: 2.058

2.  delta-Aminolaevulinate synthase in human HepG2 hepatoma cells. Repression by haemin and induction by chemicals.

Authors:  F Iwasa; S Sassa; A Kappas
Journal:  Biochem J       Date:  1989-09-15       Impact factor: 3.857

Review 3.  Drug-induced steatohepatitis.

Authors:  Ajit Dash; Robert A Figler; Arun J Sanyal; Brian R Wamhoff
Journal:  Expert Opin Drug Metab Toxicol       Date:  2016-10-27       Impact factor: 4.481

4.  Effects of dimethyl sulphoxide on the synthesis of plasma proteins in the human hepatoma HepG2. Induction of an acute-phase-like reaction.

Authors:  F Iwasa; R A Galbraith; S Sassa
Journal:  Biochem J       Date:  1988-08-01       Impact factor: 3.857

5.  The establishment and characterization of immortal hepatocyte cell lines from a mouse liver injury model.

Authors:  Prabodh Risal; Baik Hwan Cho; Karl G Sylvester; Jae-Chun Kim; Hyoung Tae Kim; Yeon Jun Jeong
Journal:  In Vitro Cell Dev Biol Anim       Date:  2011-07-30       Impact factor: 2.416

6.  A comparison of whole genome gene expression profiles of HepaRG cells and HepG2 cells to primary human hepatocytes and human liver tissues.

Authors:  Steven N Hart; Ye Li; Kaori Nakamoto; Eva-anne Subileau; David Steen; Xiao-bo Zhong
Journal:  Drug Metab Dispos       Date:  2010-03-12       Impact factor: 3.922

7.  Anti-inflammatory effect of insulin in the human hepatoma cell line HepG2 involves decreased transcription of IL-6 target genes and nuclear exclusion of FOXO1.

Authors:  Emelie Wallerstedt; Madeléne Sandqvist; Ulf Smith; Christian X Andersson
Journal:  Mol Cell Biochem       Date:  2011-02-05       Impact factor: 3.396

8.  Phyllanthin of Standardized Phyllanthus amarus Extract Attenuates Liver Oxidative Stress in Mice and Exerts Cytoprotective Activity on Human Hepatoma Cell Line.

Authors:  Rajesh Krithika; Ramtej J Verma; Pranav S Shrivastav; Lonchin Suguna
Journal:  J Clin Exp Hepatol       Date:  2011-11-09

9.  Primary hepatocytes outperform Hep G2 cells as the source of biotransformation functions in a bioartificial liver.

Authors:  S L Nyberg; R P Remmel; H J Mann; M V Peshwa; W S Hu; F B Cerra
Journal:  Ann Surg       Date:  1994-07       Impact factor: 12.969

10.  The role of inorganic metals and metalloporphyrins in the induction of haem oxygenase and heat-shock protein 70 in human hepatoma cells.

Authors:  K Mitani; H Fujita; Y Fukuda; A Kappas; S Sassa
Journal:  Biochem J       Date:  1993-03-15       Impact factor: 3.857
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.