Jie C Nguyen1, Hailey Allen2, Fang Liu3, Kaitlin M Woo4, Zhaoye Zhou3, Richard Kijowski3. 1. 1 Department of Radiology, Children's Hospital of Philadelphia, 3401 Civic Center Blvd, Philadelphia, PA 19104. 2. 2 Department of Radiology, University of Utah, Salt Lake City, UT. 3. 3 Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI. 4. 4 Department of Biostatistics and Medical Informatics, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Abstract
OBJECTIVE: The objective of our study was to use a T2 mapping sequence performed at 3 T to investigate changes in the composition and microstructure of the cartilage and menisci of the pediatric knee joint during maturation. MATERIALS AND METHODS: This retrospective study was performed of MRI examinations of 76 pediatric knees without internal derangement in 72 subjects (29 boys [mean age, 12.5 years] and 43 girls [mean age, 13.0 years]) who were evaluated with a sagittal T2 mapping sequence. T2 relaxation time values were quantitatively measured in eight cartilage subregions and in the medial and lateral menisci. Wilcoxon rank sum and Kruskal-Wallis tests were used to analyze the relationship between cartilage and meniscus T2 relaxation time values and sex and skeletal maturation, respectively. A multivariate linear regression model was used to investigate the independent association between cartilage T2 relaxation time values and age, weight, and body mass index (BMI [weight in kilograms divided by the square of height in meters]). RESULTS: There were no significant sex differences (p = 0.26-0.91) in T2 relaxation time values for cartilage or meniscus. T2 relaxation time values in each individual cartilage subregion significantly decreased (p < 0.001) with progressive maturation. T2 relaxation time values in the lateral meniscus significantly increased (p = 0.001) with maturation, whereas T2 relaxation time values in the medial meniscus did not significantly change (p = 0.82). There was a significant association (p < 0.001) between cartilage T2 relaxation time values and age independent of weight and BMI, but no significant association between cartilage T2 relaxation time values and weight (p = 0.06) and BMI (p = 0.20) independent of age. CONCLUSION: Cartilage T2 relaxation time values significantly decreased in all cartilage subregions and meniscus T2 relaxation time values significantly increased in the lateral meniscus during maturation. These changes in T2 relaxation time values reflect age-related changes in tissue composition and microstructure.
OBJECTIVE: The objective of our study was to use a T2 mapping sequence performed at 3 T to investigate changes in the composition and microstructure of the cartilage and menisci of the pediatric knee joint during maturation. MATERIALS AND METHODS: This retrospective study was performed of MRI examinations of 76 pediatric knees without internal derangement in 72 subjects (29 boys [mean age, 12.5 years] and 43 girls [mean age, 13.0 years]) who were evaluated with a sagittal T2 mapping sequence. T2 relaxation time values were quantitatively measured in eight cartilage subregions and in the medial and lateral menisci. Wilcoxon rank sum and Kruskal-Wallis tests were used to analyze the relationship between cartilage and meniscus T2 relaxation time values and sex and skeletal maturation, respectively. A multivariate linear regression model was used to investigate the independent association between cartilage T2 relaxation time values and age, weight, and body mass index (BMI [weight in kilograms divided by the square of height in meters]). RESULTS: There were no significant sex differences (p = 0.26-0.91) in T2 relaxation time values for cartilage or meniscus. T2 relaxation time values in each individual cartilage subregion significantly decreased (p < 0.001) with progressive maturation. T2 relaxation time values in the lateral meniscus significantly increased (p = 0.001) with maturation, whereas T2 relaxation time values in the medial meniscus did not significantly change (p = 0.82). There was a significant association (p < 0.001) between cartilage T2 relaxation time values and age independent of weight and BMI, but no significant association between cartilage T2 relaxation time values and weight (p = 0.06) and BMI (p = 0.20) independent of age. CONCLUSION:Cartilage T2 relaxation time values significantly decreased in all cartilage subregions and meniscus T2 relaxation time values significantly increased in the lateral meniscus during maturation. These changes in T2 relaxation time values reflect age-related changes in tissue composition and microstructure.
Authors: G B Joseph; T Baum; H Alizai; J Carballido-Gamio; L Nardo; W Virayavanich; J A Lynch; M C Nevitt; C E McCulloch; S Majumdar; T M Link Journal: Osteoarthritis Cartilage Date: 2012-04-11 Impact factor: 6.576
Authors: A Watrin; J P Ruaud; P T Olivier; N C Guingamp; P D Gonord; P A Netter; A G Blum; G M Guillot; P M Gillet; D H Loeuille Journal: Radiology Date: 2001-05 Impact factor: 11.105
Authors: Fang Liu; Kwang Won Choi; Alexey Samsonov; Richard G Spencer; John J Wilson; Walter F Block; Richard Kijowski Journal: Radiology Date: 2015-05-25 Impact factor: 11.105
Authors: E Fragonas; V Mlynárik; V Jellús; F Micali; A Piras; R Toffanin; R Rizzo; F Vittur Journal: Osteoarthritis Cartilage Date: 1998-01 Impact factor: 6.576
Authors: A R Armstrong; S Bhave; E O Buko; K L Chase; F Tóth; C S Carlson; J M Ellermann; H K W Kim; C P Johnson Journal: Osteoarthritis Cartilage Date: 2022-05-26 Impact factor: 7.507
Authors: Michael L Francavilla; Suraj D Serai; Timothy G Brandon; David M Biko; Dmitry Khrichenko; Jie C Nguyen; Rui Xiao; Nancy A Chauvin; Liya Gendler; Pamela F Weiss Journal: ACR Open Rheumatol Date: 2021-11-10