Barry J A Laird1,2,3, Trude R Balstad3,4, Tora S Solheim3,4. 1. Institute of Genetics and Molecular Medicine, University of Edinburgh. 2. St Columba's Hospice, Edinburgh, UK. 3. European Palliative Care Research Centre (PRC), Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU - Norwegian University of Science and Technology. 4. Cancer Clinic, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
Abstract
PURPOSE OF REVIEW: The lack of agreement and knowledge of optimal endpoints in cachexia trials have impeded progress in finding interventions counteracting the devastating effects cancer cachexia has on morbidity and mortality. An endpoint should both be sensitive enough to detect change and specific enough not to be influenced by other conditions or treatments. RECENT FINDINGS: There is a wealth of potential and applied endpoints in trials investigating cachexia. As of today, there is no generally acknowledged consensus, but assessments of key factors such as body composition should continue to be applied. However, the impact and effect size necessary to achieve clinical benefit using these endpoints are not clear. Further, the use of other endpoints assessing physical function, symptom evaluation and quality of life remains to be elucidated. SUMMARY: It is essential that endpoints are clinically relevant and further research is therefore needed to develop endpoints that are meaningful for patients with cachexia.
PURPOSE OF REVIEW: The lack of agreement and knowledge of optimal endpoints in cachexia trials have impeded progress in finding interventions counteracting the devastating effects cancer cachexia has on morbidity and mortality. An endpoint should both be sensitive enough to detect change and specific enough not to be influenced by other conditions or treatments. RECENT FINDINGS: There is a wealth of potential and applied endpoints in trials investigating cachexia. As of today, there is no generally acknowledged consensus, but assessments of key factors such as body composition should continue to be applied. However, the impact and effect size necessary to achieve clinical benefit using these endpoints are not clear. Further, the use of other endpoints assessing physical function, symptom evaluation and quality of life remains to be elucidated. SUMMARY: It is essential that endpoints are clinically relevant and further research is therefore needed to develop endpoints that are meaningful for patients with cachexia.
Authors: Charlie C Hall; Jane Cook; Matthew Maddocks; Richard J E Skipworth; Marie Fallon; Barry J Laird Journal: Support Care Cancer Date: 2019-04-03 Impact factor: 3.603
Authors: Guro Birgitte Stene; Trude Rakel Balstad; Anne Silja M Leer; Asta Bye; Stein Kaasa; Marie Fallon; Barry Laird; Matthew Maddocks; Tora S Solheim Journal: Cancers (Basel) Date: 2019-12-03 Impact factor: 6.639
Authors: Trude R Balstad; Cinzia Brunelli; Caroline H Pettersen; Svanhild A Schønberg; Frank Skorpen; Marie Fallon; Stein Kaasa; Asta Bye; Barry J A Laird; Guro B Stene; Tora S Solheim Journal: Front Nutr Date: 2021-01-14
Authors: Ross D Dolan; Louise E Daly; Claribel Pl Simmons; Aoife M Ryan; Wei Mj Sim; Marie Fallon; Derek G Power; Andrew Wilcock; Matthew Maddocks; Michael I Bennett; Caroline Usborne; Barry J Laird; Donald C McMillan Journal: Cancers (Basel) Date: 2020-05-08 Impact factor: 6.639