Literature DB >> 30297362

Role of Capsule in Resistance to Disinfectants, Host Antimicrobials, and Desiccation in Acinetobacter baumannii.

Kyle A Tipton1, Chui-Yoke Chin2,3, Marjan Farokhyfar1, David S Weiss1,2,3,4, Philip N Rather5,3,4.   

Abstract

Acinetobacter baumannii strain AB5075 forms two cell types distinguished by their opaque (VIR-O) or translucent (AV-T) colonies. VIR-O cells possess a thicker capsule and are more resistant to a variety of stressors than AV-T cells. However, the direct role of the capsule in these stressors was unknown. This study demonstrates that the capsule is required for resistance to disinfectants, lysozyme, and desiccation in Acinetobacter baumannii In addition, the capsule is required for survival in a mouse lung model of infection.
Copyright © 2018 American Society for Microbiology.

Entities:  

Keywords:  Acinetobacter; capsule; resistance

Mesh：

Substances：

Year:  2018        PMID： 30297362      PMCID： PMC6256795          DOI： 10.1128/AAC.01188-18

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  21 in total

1.  The K1 capsular polysaccharide of Acinetobacter baumannii strain 307-0294 is a major virulence factor.

Authors:  Thomas A Russo; Nicole R Luke; Janet M Beanan; Ruth Olson; Shauna L Sauberan; Ulrike MacDonald; L Wayne Schultz; Timothy C Umland; Anthony A Campagnari
Journal:  Infect Immun       Date:  2010-07-19       Impact factor: 3.441

2.  An ompR-envZ Two-Component System Ortholog Regulates Phase Variation, Osmotic Tolerance, Motility, and Virulence in Acinetobacter baumannii Strain AB5075.

Authors:  Kyle A Tipton; Philip N Rather
Journal:  J Bacteriol       Date:  2017-01-12       Impact factor: 3.490

3.  Molecular and functional characterization of a novel efflux pump, AmvA, mediating antimicrobial and disinfectant resistance in Acinetobacter baumannii.

Authors:  Govindan Rajamohan; Vijaya Bharathi Srinivasan; Wondwossen A Gebreyes
Journal:  J Antimicrob Chemother       Date:  2010-06-23       Impact factor: 5.790

4.  Secular trends in Acinetobacter baumannii resistance in respiratory and blood stream specimens in the United States, 2003 to 2012: A survey study.

Authors:  Marya D Zilberberg; Marin H Kollef; Andrew F Shorr
Journal:  J Hosp Med       Date:  2015-09-09       Impact factor: 2.960

5.  Analysis and nucleotide sequence of an origin of DNA replication in Acinetobacter calcoaceticus and its use for Escherichia coli shuttle plasmids.

Authors:  M Hunger; R Schmucker; V Kishan; W Hillen
Journal:  Gene       Date:  1990-03-01       Impact factor: 3.688

6.  International study of the prevalence and outcomes of infection in intensive care units.

Authors:  Jean-Louis Vincent; Jordi Rello; John Marshall; Eliezer Silva; Antonio Anzueto; Claude D Martin; Rui Moreno; Jeffrey Lipman; Charles Gomersall; Yasser Sakr; Konrad Reinhart
Journal:  JAMA       Date:  2009-12-02       Impact factor: 56.272

Review 7.  Acinetobacter baumannii: emergence of a successful pathogen.

Authors:  Anton Y Peleg; Harald Seifert; David L Paterson
Journal:  Clin Microbiol Rev       Date:  2008-07       Impact factor: 26.132

8.  The Acinetobacter baumannii Oxymoron: Commensal Hospital Dweller Turned Pan-Drug-Resistant Menace.

Authors:  Ignasi Roca; Paula Espinal; Xavier Vila-Farrés; Jordi Vila
Journal:  Front Microbiol       Date:  2012-04-23       Impact factor: 5.640

9.  Antibiotic modulation of capsular exopolysaccharide and virulence in Acinetobacter baumannii.

Authors:  Edward Geisinger; Ralph R Isberg
Journal:  PLoS Pathog       Date:  2015-02-13       Impact factor: 6.823

10.  Genome-wide identification of Acinetobacter baumannii genes necessary for persistence in the lung.

Authors:  Nengding Wang; Egon A Ozer; Mark J Mandel; Alan R Hauser
Journal:  MBio       Date:  2014-06-03       Impact factor: 7.867
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  26 in total

1.  The UDP-GalNAcA biosynthesis genes gna-gne2 are required to maintain cell envelope integrity and in vivo fitness in multi-drug resistant Acinetobacter baumannii.

Authors:  Sébastien Crépin; Elizabeth N Ottosen; Courtney E Chandler; Anna Sintsova; Robert K Ernst; Harry L T Mobley
Journal:  Mol Microbiol       Date:  2019-11-19       Impact factor: 3.501

Review 2.  Innate Immune Responses to Acinetobacter baumannii in the Airway.

Authors:  Sílvia Pires; Dane Parker
Journal:  J Interferon Cytokine Res       Date:  2019-04-23       Impact factor: 2.607

3.  Isolation and Characterisation of Bacteriophage Selective for Key Acinetobacter baumannii Capsule Chemotypes.

Authors:  Rosesathorn Soontarach; Potjanee Srimanote; Mark C Enright; George Blundell-Hunter; Matthew J Dorman; Nicholas R Thomson; Peter W Taylor; Supayang P Voravuthikunchai
Journal:  Pharmaceuticals (Basel)       Date:  2022-04-02

4.  CsrA-Controlled Proteins Reveal New Dimensions of Acinetobacter baumannii Desiccation Tolerance.

Authors:  Yasuhiro Oda; Madelyn M Shapiro; Nathan M Lewis; Xuefei Zhong; Holly K Huse; Weizhi Zhong; James E Bruce; Colin Manoil; Caroline S Harwood
Journal:  J Bacteriol       Date:  2022-03-28       Impact factor: 3.476

5.  Bacterial hydrophilins promote pathogen desiccation tolerance.

Authors:  Erin R Green; Joseph N Fakhoury; Andrew J Monteith; Hualiang Pi; David P Giedroc; Eric P Skaar
Journal:  Cell Host Microbe       Date:  2022-04-11       Impact factor: 31.316

6.  CsrA Supports both Environmental Persistence and Host-Associated Growth of Acinetobacter baumannii.

Authors:  John M Farrow; Greg Wells; Samantha Palethorpe; Mark D Adams; Everett C Pesci
Journal:  Infect Immun       Date:  2020-11-16       Impact factor: 3.441

7.  Update on Multidrug Resistance Efflux Pumps in Acinetobacter spp.

Authors:  Vanessa Kornelsen; Ayush Kumar
Journal:  Antimicrob Agents Chemother       Date:  2021-06-17       Impact factor: 5.191

8.  Acute intraperitoneal infection with a hypervirulent Acinetobacter baumannii isolate in mice.

Authors:  Greg Harris; Rhonda KuoLee; H Howard Xu; Wangxue Chen
Journal:  Sci Rep       Date:  2019-04-25       Impact factor: 4.379

Review 9.  Mechanisms Protecting Acinetobacter baumannii against Multiple Stresses Triggered by the Host Immune Response, Antibiotics and Outside-Host Environment.

Authors:  Soroosh Monem; Beata Furmanek-Blaszk; Adrianna Łupkowska; Dorota Kuczyńska-Wiśnik; Karolina Stojowska-Swędrzyńska; Ewa Laskowska
Journal:  Int J Mol Sci       Date:  2020-07-31       Impact factor: 5.923

10.  Diversity and Function of Capsular Polysaccharide in Acinetobacter baumannii.

Authors:  Jennifer K Singh; Felise G Adams; Melissa H Brown
Journal:  Front Microbiol       Date:  2019-01-09       Impact factor: 5.640
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