| Literature DB >> 3029685 |
T W Beck, M Huleihel, M Gunnell, T I Bonner, U R Rapp.
Abstract
The complete 606 amino acid sequence of the human A-raf oncogene has been deduced from the 2453 nucleotide sequence of a human T cell cDNA. A cysteine-rich region located near the amino terminus, which is highly conserved in A-raf and c-raf, shows significant homology with protein kinase C. A 5' deleted fragment of the cDNA has been incorporated into a murine retrovirus which endows the virus with the ability to transform cells in vivo and in vitro. Functionally, human A-raf is similar to v-raf and v-mos in that transformation is independent of ras gene function.Entities:
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Year: 1987 PMID： 3029685 PMCID： PMC340454 DOI： 10.1093/nar/15.2.595
Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971