Literature DB >> 6691137

The human homologs of the raf (mil) oncogene are located on human chromosomes 3 and 4.

T Bonner, S J O'Brien, W G Nash, U R Rapp, C C Morton, P Leder.   

Abstract

Two human genes that are homologous to both the murine transforming gene (oncogene) v-raf and the chicken transforming gene v-mil have been mapped by means of human-rodent somatic cell hybrids to human chromosomes previously devoid of known oncogenes. One gene, c-raf-2, which appears to be a processed pseudogene, is located on chromosome 4. The other gene, c-raf-1, which appears to be the active gene, is located on chromosome 3 and has been regionally mapped by chromosomal in situ hybridization to 3p25. This assignment correlates with specific chromosomal abnormalities associated with certain human malignancies.

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Year:  1984        PMID： 6691137     DOI： 10.1126/science.6691137

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  50 in total

Review 1.  Comparative map for mice and humans.

Authors:  J H Nadeau; M T Davisson; D P Doolittle; P Grant; A L Hillyard; M R Kosowsky; T H Roderick
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

Review 2.  Mouse chromosome 6.

Authors:  R W Elliott; K J Moore
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

Review 3.  Molecular biology and respiratory disease. 4. Cancer genes.

Authors:  K Sikora; G Ong
Journal:  Thorax       Date:  1990-05       Impact factor: 9.139

4.  Localization of the human HF.10 finger gene on a chromosome region (3p21-22) frequently deleted in human cancers.

Authors:  E Donti; L Lanfrancone; K Huebner; A Pascucci; G Venti; G Pengue; F Grignani; C M Croce; L Lania; P G Pelicci
Journal:  Hum Genet       Date:  1990-04       Impact factor: 4.132

Review 5.  Comparative map for mice and humans.

Authors:  J H Nadeau; M T Davisson; D P Doolittle; P Grant; A L Hillyard; M Kosowsky; T H Roderick
Journal:  Mamm Genome       Date:  1991       Impact factor: 2.957

Review 6.  Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyond.

Authors:  Matthew Holderfield; Marian M Deuker; Frank McCormick; Martin McMahon
Journal:  Nat Rev Cancer       Date:  2014-07       Impact factor: 60.716

7.  Mapping of the interleukin 5 receptor gene to human chromosome 3 p25-p26 and to mouse chromosome 6 close to the Raf-1 locus with polymorphic tandem repeat sequences.

Authors:  C O Jacob; K Mykytyn; T Varcony; H A Drabkin
Journal:  Mamm Genome       Date:  1993       Impact factor: 2.957

Review 8.  Vemurafenib: the first drug approved for BRAF-mutant cancer.

Authors:  Gideon Bollag; James Tsai; Jiazhong Zhang; Chao Zhang; Prabha Ibrahim; Keith Nolop; Peter Hirth
Journal:  Nat Rev Drug Discov       Date:  2012-10-12       Impact factor: 84.694

9.  Long range restriction map of the von Hippel-Lindau gene region on human chromosome 3p.

Authors:  S C Szymanski; H Hummerich; F Latif; M I Lerman; G Röhrborn; E Schröder
Journal:  Hum Genet       Date:  1993-10-01       Impact factor: 4.132

10.  Actively transcribed genes in the raf oncogene group, located on the X chromosome in mouse and human.

Authors:  K Huebner; A ar-Rushdi; C A Griffin; M Isobe; C Kozak; B S Emanuel; L Nagarajan; J L Cleveland; T I Bonner; M D Goldsborough
Journal:  Proc Natl Acad Sci U S A       Date:  1986-06       Impact factor: 11.205
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