Joane Matta1, Nicolas Hoertel2, Emmanuelle Kesse-Guyot3, Marie Plesz4, Emmanuel Wiernik5, Claire Carette6, Sébastien Czernichow7, Frédéric Limosin2, Marcel Goldberg5, Marie Zins5, Cédric Lemogne2. 1. Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, Paris, France; AP-HP, Hôpitaux Universitaires Paris Ouest, Service de Psychiatrie de l'adulte et du sujet âgé, Paris, France; Inserm, U894, Centre Psychiatrie et Neurosciences, Paris, France. Electronic address: joane.matta@inserm.fr. 2. Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, Paris, France; AP-HP, Hôpitaux Universitaires Paris Ouest, Service de Psychiatrie de l'adulte et du sujet âgé, Paris, France; Inserm, U894, Centre Psychiatrie et Neurosciences, Paris, France. 3. Inserm (U1153); Inra; Cnam; University of Paris 5,7 & 13, Paris, France. 4. Inra, ENS, EHESS, CNRS, Centre Maurice Halbwachs UMR 8097, Paris, France. 5. Inserm, Population-based Epidemiological Cohorts Unit, UMS 011, Villejuif, France. 6. Service de Nutrition, hôpital européen Georges-Pompidou, Paris, France. 7. Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, Paris, France; Service de Nutrition, hôpital européen Georges-Pompidou, Paris, France.
Abstract
BACKGROUND: The association between depression and the metabolic syndrome remains poorly understood. Diet and physical activity may partly explain this association. METHODS: Baseline data on 64,861 subjects from the French population-based Constances cohort was analyzed. Depressive symptoms were determined with the Center of Epidemiologic Studies Depression (CES-D) scale. A CES-D score ≥ 19 combined with self-reported limitations related to depressive symptoms was used to define depression. The metabolic syndrome was defined according to the International Diabetes Federation criteria. Dietary patterns were determined with a food frequency questionnaire and a principal component analysis. Physical activity was measured with 3 questions resulting in a composite 6-point scale. Associations between depression and the metabolic syndrome were estimated through logistic regression and path analysis. RESULTS: The odds-ratios (95% confidence interval) for the association between depression and the metabolic syndrome, adjusting for age, sex, education and income, was 1.75 (1.57-1.96). The path analysis showed that 23% of this association was explained by diet and physical activity, 67% being attributed to physical activity. LIMITATIONS: The cross-sectional nature of the analyses warrants the results to be confirmed by longitudinal analyses. CONCLUSION: Diet and physical activity might partially explain the association between depressive symptoms and metabolic syndrome but other factors (e.g. inflammatory factors) are involved.
BACKGROUND: The association between depression and the metabolic syndrome remains poorly understood. Diet and physical activity may partly explain this association. METHODS: Baseline data on 64,861 subjects from the French population-based Constances cohort was analyzed. Depressive symptoms were determined with the Center of Epidemiologic Studies Depression (CES-D) scale. A CES-D score ≥ 19 combined with self-reported limitations related to depressive symptoms was used to define depression. The metabolic syndrome was defined according to the International Diabetes Federation criteria. Dietary patterns were determined with a food frequency questionnaire and a principal component analysis. Physical activity was measured with 3 questions resulting in a composite 6-point scale. Associations between depression and the metabolic syndrome were estimated through logistic regression and path analysis. RESULTS: The odds-ratios (95% confidence interval) for the association between depression and the metabolic syndrome, adjusting for age, sex, education and income, was 1.75 (1.57-1.96). The path analysis showed that 23% of this association was explained by diet and physical activity, 67% being attributed to physical activity. LIMITATIONS: The cross-sectional nature of the analyses warrants the results to be confirmed by longitudinal analyses. CONCLUSION: Diet and physical activity might partially explain the association between depressive symptoms and metabolic syndrome but other factors (e.g. inflammatory factors) are involved.
Authors: Julia W Felton; Julia M Shadur; Mazneen Havewala; Jude Cassidy; Carl W Lejuez; Andrea Chronis-Tuscano Journal: J Psychopathol Behav Assess Date: 2022-02-28
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Authors: B Kuriya; O Schieir; M F Valois; J E Pope; G Boire; L Bessette; G Hazlewood; J C Thorne; D Tin; C Hitchon; S J Bartlett; E C Keystone; V P Bykerk; L Barra Journal: ACR Open Rheumatol Date: 2019-08-28
Authors: Melania Prete; Anna Luzzetti; Livia S A Augustin; Giuseppe Porciello; Concetta Montagnese; Ilaria Calabrese; Giada Ballarin; Sergio Coluccia; Linia Patel; Sara Vitale; Elvira Palumbo; Egidio Celentano; Carlo La Vecchia; Anna Crispo Journal: Nutrients Date: 2021-06-03 Impact factor: 5.717