| Literature DB >> 30295664 |
Eduardo de Souza Nicolau1, Kevin Augusto Farias de Alvarenga1, Helia Tenza-Ferrer1, Matheus Carvalho Alves Nogueira1, Fernanda Donizete Rezende1, Nycolle Ferreira Nicolau1, Mélcar Collodetti1, Débora Marques de Miranda1, Luiz Alexandre Viana Magno1, Marco Aurélio Romano-Silva2.
Abstract
Transcranial direct current stimulation (tDCS) is a non-invasive neuromodulation technique proposed as an alternative or complementary treatment for several neuropsychiatric diseases. The biological effects of tDCS are not fully understood, which is in part explained due to the difficulty in obtaining human brain tissue. This protocol describes a tDCS mouse model that uses a chronically implanted electrode allowing the study of the long-lasting biological effects of tDCS. In this experimental model, tDCS changes the cortical gene expression and offers a prominent contribution to the understanding of the rationale for its therapeutic use.Entities:
Mesh:
Year: 2018 PMID: 30295664 PMCID: PMC6235291 DOI: 10.3791/58517
Source DB: PubMed Journal: J Vis Exp ISSN: 1940-087X Impact factor: 1.355