Zhijun Wu1, Zhe Huang2, Yuntao Wu2, Shue Huang3, Yanxiu Wang2, Haiyan Zhao2, Shuohua Chen4, Shouling Wu2, Xiang Gao3. 1. 1 Department of Cardiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 2. 2 Department of Cardiology, Kailuan Hospital, Tangshan, China. 3. 3 Department of Nutritional Sciences, Pennsylvania State University, State college, PA, USA. 4. 4 Health Care Center, Kailuan Medical Group, Tangshan, China.
Abstract
BACKGROUND: Sedentary time was associated with myocardial infarction (MI) and metabolic diseases in previous studies. PURPOSE: To investigate whether sedentary time measured before disease onset was associated with all-cause mortality among MI survivors and whether the sedentary time-mortality association was mediated by physical activity status and metabolic phenotypes. METHODS: In this prospective community-based cohort including 101,510 Chinese adults, we used sedentary time, evaluated at 2006 (baseline), to predict further all-cause mortality among individuals who then developed new onset MI from 2006 to December 2013 ( n = 989). The post-MI mortality was ascertained after the first non-fatal MI until December 2014. We assessed the mediating effects of physical inactivity and metabolic factors on the sedentary time-mortality association. RESULTS: During 7 years follow up, 180 deaths occurred among these participants with incident MI. Prolonged sedentary time was associated with a higher risk of mortality among MI survivors. The adjusted hazard ratio (HR) of mortality for sedentary time 4-8 hours/day versus <4 hours/day, was 1.62 (95% confidence interval (CI) 1.14-2.31). A high amount of sedentary time (>4 hours/day) and inactive physical activity had an increased risk of all-cause mortality (HR: 2.74, 95% CI 1.34-5.60), relative to those with sedentary time ≤4 hours/day and moderate/vigorous physical activity. Physical inactivity and metabolic factors mediated a small proportion (≤9.2 % for all) of the total association between sedentary time and post-MI mortality. CONCLUSION: High sedentary time was significantly associated with all-cause mortality among MI survivors, independent of physical activity status and metabolic abnormalities.
BACKGROUND: Sedentary time was associated with myocardial infarction (MI) and metabolic diseases in previous studies. PURPOSE: To investigate whether sedentary time measured before disease onset was associated with all-cause mortality among MI survivors and whether the sedentary time-mortality association was mediated by physical activity status and metabolic phenotypes. METHODS: In this prospective community-based cohort including 101,510 Chinese adults, we used sedentary time, evaluated at 2006 (baseline), to predict further all-cause mortality among individuals who then developed new onset MI from 2006 to December 2013 ( n = 989). The post-MI mortality was ascertained after the first non-fatal MI until December 2014. We assessed the mediating effects of physical inactivity and metabolic factors on the sedentary time-mortality association. RESULTS: During 7 years follow up, 180 deaths occurred among these participants with incident MI. Prolonged sedentary time was associated with a higher risk of mortality among MI survivors. The adjusted hazard ratio (HR) of mortality for sedentary time 4-8 hours/day versus <4 hours/day, was 1.62 (95% confidence interval (CI) 1.14-2.31). A high amount of sedentary time (>4 hours/day) and inactive physical activity had an increased risk of all-cause mortality (HR: 2.74, 95% CI 1.34-5.60), relative to those with sedentary time ≤4 hours/day and moderate/vigorous physical activity. Physical inactivity and metabolic factors mediated a small proportion (≤9.2 % for all) of the total association between sedentary time and post-MI mortality. CONCLUSION: High sedentary time was significantly associated with all-cause mortality among MI survivors, independent of physical activity status and metabolic abnormalities.
Authors: B M A van Bakel; S H Kroesen; A Günal; A Scheepmaker; W R M Aengevaeren; F F Willems; R Wondergem; M F Pisters; J Dam; A M Janssen; M de Bruin; M T E Hopman; D H J Thijssen; T M H Eijsvogels Journal: BMJ Open Sport Exerc Med Date: 2022-05-24
Authors: Bram M A van Bakel; Esmée A Bakker; Femke de Vries; Dick H J Thijssen; Thijs M H Eijsvogels Journal: Int J Environ Res Public Health Date: 2021-11-13 Impact factor: 4.614
Authors: Ville Vasankari; Jari Halonen; Tommi Vasankari; Vesa Anttila; Juhani Airaksinen; Harri Sievänen; Juha Hartikainen Journal: Am J Prev Cardiol Date: 2021-01-09