Literature DB >> 30288229

Synthesis of novel perillyl-dihydropyrimidinone hybrids designed for antiproliferative activity.

Vinicius Vendrusculo1, Vanessa P de Souza1, Luiz Antônio M Fontoura2,3, Marcelo G M D'Oca4, Thais P Banzato5,6, Paula A Monteiro5,6, Ronaldo A Pilli7, João Ernesto de Carvalho5,6, Dennis Russowsky1.   

Abstract

A series of fifteen novel dihydropyrimidinone hybrid compounds were synthesized in good yields via a multicomponent reaction combined with the Huisgen reaction. The antiproliferative activity was investigated against nine tumor cell lines, and four hybrid compounds (TGI < 10 μM) showed promising antiproliferative activity against the tumor cell lines OVCAR-3 (ovarian), UACC-62 (melanoma) and U251 (glioma). Several hybrid compounds assayed have high TGI values (TGI 147.92-507.82) for the human keratinocyte cell line (HaCat), which reveals selectivity to cancer cells.

Entities:  

Year:  2018        PMID： 30288229      PMCID： PMC6151448          DOI： 10.1039/c8md00270c

Source DB:  PubMed          Journal:  Medchemcomm        ISSN： 2040-2503            Impact factor:   3.597


  32 in total

1.  1,2,3-Triazole tethered β-lactam-chalcone bifunctional hybrids: synthesis and anticancer evaluation.

Authors:  Pardeep Singh; Raghu Raj; Vipan Kumar; Mohinder P Mahajan; P M S Bedi; Tandeep Kaur; A K Saxena
Journal:  Eur J Med Chem       Date:  2011-10-21       Impact factor: 6.514

Review 2.  Designed multiple ligands. An emerging drug discovery paradigm.

Authors:  Richard Morphy; Zoran Rankovic
Journal:  J Med Chem       Date:  2005-10-20       Impact factor: 7.446

Review 3.  Multicomponent therapeutics for networked systems.

Authors:  Curtis T Keith; Alexis A Borisy; Brent R Stockwell
Journal:  Nat Rev Drug Discov       Date:  2005-01       Impact factor: 84.694

Review 4.  Preclinical development and clinical use of perillyl alcohol for chemoprevention and cancer therapy.

Authors:  Thomas C Chen; Clovis O Da Fonseca; Axel H Schönthal
Journal:  Am J Cancer Res       Date:  2015-04-15       Impact factor: 6.166

5.  Novel tacrine-8-hydroxyquinoline hybrids as multifunctional agents for the treatment of Alzheimer's disease, with neuroprotective, cholinergic, antioxidant, and copper-complexing properties.

Authors:  María Isabel Fernández-Bachiller; Concepción Pérez; Gema C González-Muñoz; Santiago Conde; Manuela G López; Mercedes Villarroya; Antonio G García; María Isabel Rodríguez-Franco
Journal:  J Med Chem       Date:  2010-07-08       Impact factor: 7.446

6.  Long-term outcome in patients with recurrent malignant glioma treated with Perillyl alcohol inhalation.

Authors:  Clovis O DA Fonseca; Raphael M Teixeira; Júlio Cesar T Silva; Juliana DE Saldanha DA Gama Fischer; Osório C Meirelles; Jose Alberto Landeiro; Thereza Quirico-Santos
Journal:  Anticancer Res       Date:  2013-12       Impact factor: 2.480

7.  Perillyl alcohol as a protective modulator against rat hepatocarcinogenesis via amelioration of oxidative damage and cell proliferation.

Authors:  S Sultana; S Nafees; A Q Khan
Journal:  Hum Exp Toxicol       Date:  2013-03-27       Impact factor: 2.903

8.  Synthesis, antimalarial and antitubercular activity of acetylenic chalcones.

Authors:  Renate H Hans; Eric M Guantai; Carmen Lategan; Peter J Smith; Baojie Wan; Scott G Franzblau; Jiri Gut; Philip J Rosenthal; Kelly Chibale
Journal:  Bioorg Med Chem Lett       Date:  2009-12-23       Impact factor: 2.823

9.  A monastrol-derived compound, LaSOM 63, inhibits ecto-5'nucleotidase/CD73 activity and induces apoptotic cell death of glioma cell lines.

Authors:  Fabrício Figueiró; Franciane Brackmann Mendes; Patricia Frasson Corbelini; Fernanda Janarelli; Elisa Helena Farias Jandrey; Dennis Russowsky; Vera Lucia Eifler-Lima; Ana Maria Oliveira Battastini
Journal:  Anticancer Res       Date:  2014-04       Impact factor: 2.480

10.  Select pyrimidinones inhibit the propagation of the malarial parasite, Plasmodium falciparum.

Authors:  Annette N Chiang; Juan-Carlos Valderramos; Raghavan Balachandran; Raj J Chovatiya; Brian P Mead; Corinne Schneider; Samantha L Bell; Michael G Klein; Donna M Huryn; Xiaojiang S Chen; Billy W Day; David A Fidock; Peter Wipf; Jeffrey L Brodsky
Journal:  Bioorg Med Chem       Date:  2009-01-20       Impact factor: 3.641
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  3 in total

Review 1.  A Review on Recent Advances in Nitrogen-Containing Molecules and Their Biological Applications.

Authors:  Nagaraju Kerru; Lalitha Gummidi; Suresh Maddila; Kranthi Kumar Gangu; Sreekantha B Jonnalagadda
Journal:  Molecules       Date:  2020-04-20       Impact factor: 4.411

2.  A comparative study between Cu(INA)2-MOF and [Cu(INA)2(H2O)4] complex for a click reaction and the Biginelli reaction under solvent-free conditions.

Authors:  Julia C Mansano Willig; Gustavo Granetto; Danielly Reginato; Felipe R Dutra; Érica Fernanda Poruczinski; Isadora M de Oliveira; Helio A Stefani; Sílvia D de Campos; Élvio A de Campos; Flávia Manarin; Giancarlo V Botteselle
Journal:  RSC Adv       Date:  2020-01-21       Impact factor: 4.036

Review 3.  The Monoterpenoid Perillyl Alcohol: Anticancer Agent and Medium to Overcome Biological Barriers.

Authors:  Thomas C Chen; Clovis O da Fonseca; Daniel Levin; Axel H Schönthal
Journal:  Pharmaceutics       Date:  2021-12-16       Impact factor: 6.321
  3 in total

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