Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Designed multiple ligands. An emerging drug discovery paradigm.

× No keyword cloud information.

210 in total

1. Bifunctional μ/δ opioid peptides: variation of the type and length of the linker connecting the two components.

Authors: Jinguo Ding; Carole Lemieux; Nga N Chung; Peter W Schiller
Journal: Chem Biol Drug Des Date: 2012-01-04 Impact factor: 2.817

2. New organoruthenium complexes with bioactive thiosemicarbazones as co-ligands: potential anti-trypanosomal agents.

Authors: Bruno Demoro; Cynthia Sarniguet; Roberto Sánchez-Delgado; Miriam Rossi; Daniel Liebowitz; Francesco Caruso; Claudio Olea-Azar; Virtudes Moreno; Andrea Medeiros; Marcelo A Comini; Lucía Otero; Dinorah Gambino
Journal: Dalton Trans Date: 2011-12-02 Impact factor: 4.390

3. Dual targeting of histone deacetylase and topoisomerase II with novel bifunctional inhibitors.

Authors: William Guerrant; Vishal Patil; Joshua C Canzoneri; Adegboyega K Oyelere
Journal: J Med Chem Date: 2012-02-13 Impact factor: 7.446

Review 4. Finding the sweet spot: the role of nature and nurture in medicinal chemistry.

Authors: Michael M Hann; György M Keserü
Journal: Nat Rev Drug Discov Date: 2012-04-30 Impact factor: 84.694

5. Biological and conformational evaluation of bifunctional compounds for opioid receptor agonists and neurokinin 1 receptor antagonists possessing two penicillamines.

Authors: Takashi Yamamoto; Padma Nair; Neil E Jacobsen; Vinod Kulkarni; Peg Davis; Shou-Wu Ma; Edita Navratilova; Henry I Yamamura; Todd W Vanderah; Frank Porreca; Josephine Lai; Victor J Hruby
Journal: J Med Chem Date: 2010-08-12 Impact factor: 7.446

6. Development and in vitro characterization of a novel bifunctional μ-agonist/δ-antagonist opioid tetrapeptide.

Authors: Lauren C Purington; Katarzyna Sobczyk-Kojiro; Irina D Pogozheva; John R Traynor; Henry I Mosberg
Journal: ACS Chem Biol Date: 2011-10-11 Impact factor: 5.100

7. Computer-Aided Fragment Growing Strategies to Design Dual Inhibitors of Soluble Epoxide Hydrolase and LTA4 Hydrolase.

Authors: Lena Hefke; Kerstin Hiesinger; W Felix Zhu; Jan S Kramer; Ewgenij Proschak
Journal: ACS Med Chem Lett Date: 2020-04-08 Impact factor: 4.345

8. A chloroquine-like molecule designed to reverse resistance in Plasmodium falciparum.

Authors: Steven J Burgess; Audrey Selzer; Jane Xu Kelly; Martin J Smilkstein; Michael K Riscoe; David H Peyton
Journal: J Med Chem Date: 2006-09-07 Impact factor: 7.446

9. Identification of diaryl 5-amino-1,2,4-oxadiazoles as tubulin inhibitors: the special case of 3-(2-fluorophenyl)-5-(4-methoxyphenyl)amino-1,2,4-oxadiazole.

Authors: Andrei A Gakh; Andrey V Sosnov; Mikhail Krasavin; Tam Luong Nguyen; Ernest Hamel
Journal: Bioorg Med Chem Lett Date: 2013-01-11 Impact factor: 2.823

10. Design and synthesis of a hybrid potentiator-corrector agonist of the cystic fibrosis mutant protein DeltaF508-CFTR.

Authors: Aaron D Mills; Choong Yoo; Jeffrey D Butler; Baoxue Yang; A S Verkman; Mark J Kurth
Journal: Bioorg Med Chem Lett Date: 2009-11-13 Impact factor: 2.823