A Romanos-Nanclares1, Estefania Toledo2,3,4, I Gardeazabal1,5, J J Jiménez-Moleón6,7, M A Martínez-González1,8,9,10, A Gea1,8,9. 1. University of Navarra, Department of Preventive Medicine and Public Health, C/ Irunlarrea, 1, 31008, Pamplona, Spain. 2. University of Navarra, Department of Preventive Medicine and Public Health, C/ Irunlarrea, 1, 31008, Pamplona, Spain. etoledo@unav.es. 3. IdiSNA, Navarra Institute for Health Research, Pamplona, Spain. etoledo@unav.es. 4. CIBERobn Physiopathology of Obesity and Nutrition, Institute of Health Carlos III (ISCIII), Madrid, Spain. etoledo@unav.es. 5. Department of Oncology, University of Navarra Clinic, Pamplona, Spain. 6. CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain. 7. Department of Preventive Medicine and Publich Health, School of Medicine, University of Granada, Instituto de Investigación Biosanitaria de Granada ibs-GRANADA, Servicio Andaluz de Salud/Universidad de Granada, Granada, Spain. 8. IdiSNA, Navarra Institute for Health Research, Pamplona, Spain. 9. CIBERobn Physiopathology of Obesity and Nutrition, Institute of Health Carlos III (ISCIII), Madrid, Spain. 10. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, USA.
Abstract
PURPOSE: Breast cancer (BC) incidence is increasing worldwide. Higher insulin resistance may potentially lead to an increased risk of BC. Sugar-sweetened beverages (SSB) are an acknowledged dietary factor that increases insulin resistance. However, the association between SSB and BC has not been widely explored. We evaluated the association between baseline consumption of SSB and the incidence of BC among relatively young women in a cohort of Spanish university graduates. METHODS: We evaluated 10,713 middle-aged, Spanish female university graduates (median age 33) from the Seguimiento Universidad de Navarra (SUN) cohort, initially free of BC. SSB consumption was collected at baseline using a validated 136-item semi-quantitative food-frequency questionnaire. Incidence of BC was confirmed by a trained oncologist using medical records. We fitted Cox regression models to assess the relationship between baseline categories of SSB consumption and the incidence of BC during follow-up. We stratified the analyses by menopausal status. RESULTS: During 106,189 person-years follow-up, 100 incident cases of BC were confirmed. Among postmenopausal women, regular consumption of SSB was associated with a significantly higher incidence of BC (HR 2.12; 95% CI 1.02, 4.41) in the fully adjusted model, compared to women who never or seldom consumed SSB. No association was found among premenopausal women (HR 1.16; 95% CI 0.66, 2.07). CONCLUSIONS: Even though the number of cases was small, in this Mediterranean cohort, we observed a direct association between SSB consumption and BC risk among postmenopausal women. Nonetheless further larger longitudinal studies are needed to support this association.
PURPOSE:Breast cancer (BC) incidence is increasing worldwide. Higher insulin resistance may potentially lead to an increased risk of BC. Sugar-sweetened beverages (SSB) are an acknowledged dietary factor that increases insulin resistance. However, the association between SSB and BC has not been widely explored. We evaluated the association between baseline consumption of SSB and the incidence of BC among relatively young women in a cohort of Spanish university graduates. METHODS: We evaluated 10,713 middle-aged, Spanish female university graduates (median age 33) from the Seguimiento Universidad de Navarra (SUN) cohort, initially free of BC. SSB consumption was collected at baseline using a validated 136-item semi-quantitative food-frequency questionnaire. Incidence of BC was confirmed by a trained oncologist using medical records. We fitted Cox regression models to assess the relationship between baseline categories of SSB consumption and the incidence of BC during follow-up. We stratified the analyses by menopausal status. RESULTS: During 106,189 person-years follow-up, 100 incident cases of BC were confirmed. Among postmenopausal women, regular consumption of SSB was associated with a significantly higher incidence of BC (HR 2.12; 95% CI 1.02, 4.41) in the fully adjusted model, compared to women who never or seldom consumed SSB. No association was found among premenopausal women (HR 1.16; 95% CI 0.66, 2.07). CONCLUSIONS: Even though the number of cases was small, in this Mediterranean cohort, we observed a direct association between SSB consumption and BC risk among postmenopausal women. Nonetheless further larger longitudinal studies are needed to support this association.
Entities:
Keywords:
Breast cancer; Cohort; Primary prevention; Sugar-sweetened beverage
Authors: Cesar I Fernandez-Lazaro; Andrea Romanos-Nanclares; Rodrigo Sánchez-Bayona; Alfredo Gea; Carmen Sayon-Orea; Miguel A Martinez-Gonzalez; Estefanía Toledo Journal: Eur J Nutr Date: 2021-04-05 Impact factor: 5.614
Authors: Cesar I Fernandez-Lazaro; Miguel Ángel Martínez-González; Inmaculada Aguilera-Buenosvinos; Alfredo Gea; Miguel Ruiz-Canela; Andrea Romanos-Nanclares; Estefanía Toledo Journal: Antioxidants (Basel) Date: 2021-02-24
Authors: Andrea Romanos-Nanclares; Walter C Willett; Bernard A Rosner; Laura C Collins; Frank B Hu; Estefania Toledo; A Heather Eliassen Journal: Cancer Epidemiol Biomarkers Prev Date: 2021-07-21 Impact factor: 4.254