Yali Wu1,2, Jian Qu1, Huabing Li3, Haiyan Yuan1, Qi Guo4, Zhanbo Ouyang1, Qiong Lu1. 1. Department of Pharmacy, The Second Xiangya Hospital of Central South University, Changsha, China. 2. Department of Science and Education, Hunan Provincial Maternal and Child Health Care Hospital, Changsha, China. 3. Department of Radiology, The Second Xiangya Hospital of Central South University, Changsha, China. 4. Endocrinology Research Center, The Xiangya Hospital of Central South University, Changsha, China.
Abstract
BACKGROUND: Adolescents with anorexia nervosa (AN) have low body mass and low bone mineral density (BMD). Growth differentiation factor 8 (Myostatin, GDF8) and its homologue growth differentiation factor 11 (GDF11), members of the TGF-β super-family, play an important role in muscle regeneration and bone metabolism in healthy individuals. However, their association with BMD in AN is unknown. The present study was undertaken to investigate the relationship between GDF8, GDF11 and BMD in adolescent girls with AN. METHODS: Serum GDF8, GDF11 and BMD were determined in 25 girls (12-16 years old) with AN and 31 healthy girls (12-16 years old). RESULTS: Growth differentiation factor 8 levels were lower in AN subjects. On the contrary, GDF11 levels were higher in AN subjects than controls. There was no relationship between GDF8 and BMD. A significant negative correlation between GDF11 and BMD was found. In multiple linear stepwise regression analysis, BMI, 25-hydroxyvitamin D, GDF11, or lean mass, but not fat mass and GDF8, were independent predictors of BMD in the AN and control groups separately. CONCLUSIONS: Growth differentiation factor 11 was independent predictor of BMD in girls with AN. It suggested that GDF11 exerts a negative effect on bone mass.
BACKGROUND: Adolescents with anorexia nervosa (AN) have low body mass and low bone mineral density (BMD). Growth differentiation factor 8 (Myostatin, GDF8) and its homologue growth differentiation factor 11 (GDF11), members of the TGF-β super-family, play an important role in muscle regeneration and bone metabolism in healthy individuals. However, their association with BMD in AN is unknown. The present study was undertaken to investigate the relationship between GDF8, GDF11 and BMD in adolescent girls with AN. METHODS: Serum GDF8, GDF11 and BMD were determined in 25 girls (12-16 years old) with AN and 31 healthy girls (12-16 years old). RESULTS:Growth differentiation factor 8 levels were lower in AN subjects. On the contrary, GDF11 levels were higher in AN subjects than controls. There was no relationship between GDF8 and BMD. A significant negative correlation between GDF11 and BMD was found. In multiple linear stepwise regression analysis, BMI, 25-hydroxyvitamin D, GDF11, or lean mass, but not fat mass and GDF8, were independent predictors of BMD in the AN and control groups separately. CONCLUSIONS:Growth differentiation factor 11 was independent predictor of BMD in girls with AN. It suggested that GDF11 exerts a negative effect on bone mass.
Authors: Laurent Maïmoun; Denis Mariano-Goulart; Helena Huguet; Eric Renard; Patrick Lefebvre; Marie-Christine Picot; Anne-Marie Dupuy; Jean-Paul Cristol; Philippe Courtet; Vincent Boudousq; Antoine Avignon; Sébastien Guillaume; Ariane Sultan Journal: Endocr Connect Date: 2022-05-10 Impact factor: 3.221
Authors: Laurent Maïmoun; Thibault Mura; Vincent Attalin; Anne Marie Dupuy; Jean-Paul Cristol; Antoine Avignon; Denis Mariano-Goulart; Ariane Sultan Journal: J Clin Med Date: 2020-04-17 Impact factor: 4.241