Luis E Simental-Mendía1, Fernando Guerrero-Romero2. 1. Unidad de Investigación Biomédica, Delegación Durango, Instituto Mexicano del Seguro Social, México. Electronic address: luis_simental81@hotmail.com. 2. Unidad de Investigación Biomédica, Delegación Durango, Instituto Mexicano del Seguro Social, México.
Abstract
OBJECTIVES: The aim of this study was to explore the effect of resveratrol supplementation on lipid profile in individuals with dyslipidemia. METHODS:Apparently healthy men and non-pregnant women 20 to 65 y of age with new diagnosis of dyslipidemia were enrolled in a randomized double-blind, placebo-controlled trial and randomly allocated to receive either resveratrol 100 mg/d or placebo (sucrose 0.5 g/d) for 2 mo. Smoking, alcohol intake, diabetes, acute or chronic renal or hepatic diseases, malignancy, cardiovascular disease, serum triacylglycerol levels ≥400 mg/dL, low-density lipoprotein cholesterol levels ≥190 mg/dL, and consumption of lipid-lowering drugs or supplements containing resveratrol were exclusion criteria. RESULTS:Seventy-one individuals with new diagnosis of dyslipidemia were enrolled and randomly allocated to the resveratrol (n = 35) or placebo groups (n = 36). At baseline, there were no significant differences between the study groups. After intervention period, individuals in the resveratrol group showed a significant decrease in total cholesterol (201.4 ± 34.4 versus 220.6 ± 37.4, P = 0.04) and triacylglycerol (133.4 ± 55.3 versus 166.7 ± 68.5, P = 0.04) concentrations compared with the placebo group, without significant statistical differences for high-density lipoprotein cholesterol and low-density lipoprotein cholesterol levels. CONCLUSION: The results suggest that resveratrol supplementation significantly reduces total cholesterol and triacylglycerol concentrations in individuals with dyslipidemia.
RCT Entities:
OBJECTIVES: The aim of this study was to explore the effect of resveratrol supplementation on lipid profile in individuals with dyslipidemia. METHODS: Apparently healthy men and non-pregnant women 20 to 65 y of age with new diagnosis of dyslipidemia were enrolled in a randomized double-blind, placebo-controlled trial and randomly allocated to receive either resveratrol 100 mg/d or placebo (sucrose 0.5 g/d) for 2 mo. Smoking, alcohol intake, diabetes, acute or chronic renal or hepatic diseases, malignancy, cardiovascular disease, serum triacylglycerol levels ≥400 mg/dL, low-density lipoprotein cholesterol levels ≥190 mg/dL, and consumption of lipid-lowering drugs or supplements containing resveratrol were exclusion criteria. RESULTS: Seventy-one individuals with new diagnosis of dyslipidemia were enrolled and randomly allocated to the resveratrol (n = 35) or placebo groups (n = 36). At baseline, there were no significant differences between the study groups. After intervention period, individuals in the resveratrol group showed a significant decrease in total cholesterol (201.4 ± 34.4 versus 220.6 ± 37.4, P = 0.04) and triacylglycerol (133.4 ± 55.3 versus 166.7 ± 68.5, P = 0.04) concentrations compared with the placebo group, without significant statistical differences for high-density lipoprotein cholesterol and low-density lipoprotein cholesterol levels. CONCLUSION: The results suggest that resveratrol supplementation significantly reduces total cholesterol and triacylglycerol concentrations in individuals with dyslipidemia.
Authors: Sara A Harper; John R Bassler; Sujitha Peramsetty; Youfeng Yang; Lisa M Roberts; Devin Drummer; Robert T Mankowski; Christiaan Leeuwenburgh; Karina Ricart; Rakesh P Patel; Marcas M Bamman; Stephen D Anton; Byron C Jaeger; Thomas W Buford Journal: Exp Gerontol Date: 2020-10-15 Impact factor: 4.032