| Literature DB >> 30278218 |
Eugene Moore1, Alba Grifoni2, Daniela Weiskopf2, Veronique Schulten2, Cecilia S Lindestam Arlehamn2, Michael Angelo2, John Pham2, Shay Leary3, John Sidney2, David Broide4, April Frazier2, Elizabeth Phillips5, Simon Mallal5, Steven J Mack6, Alessandro Sette7.
Abstract
DNA sequence-based typing at the HLA-A, -B, -C, -DPB1, -DQA1, -DQB1, and -DRB1 loci was performed on 496 healthy adult donors from San Diego, California, to characterize allele frequencies in support of studies of T cell responses to common allergens. Deviations from Hardy Weinberg proportions were detected at each locus except A and C. Several alleles were found in more than 15% of individuals, including the class II alleles DPB1∗02:01, DPB1∗04:01, DQA1∗01:02, DQA1∗05:01, DQB1∗03:01, and the class I allele A∗02:01. Genotype data will be available in the Allele Frequencies Net Database (AFND 3562).Entities:
Keywords: Allergy; HLA alleles; HLA typing; San Diego, California
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Substances:
Year: 2018 PMID: 30278218 PMCID: PMC6537871 DOI: 10.1016/j.humimm.2018.09.008
Source DB: PubMed Journal: Hum Immunol ISSN: 0198-8859 Impact factor: 2.850