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Literature DB >> 30277234

Site-specific one-pot triple click labeling for DNA and RNA.

Marie-Luise Winz¹, Eva Christina Linder, Juliane Becker, Andres Jäschke.

Abstract

We report site-specific triple click labeling for DNA and RNA in a one-pot setup by performing inverse electron demand Diels-Alder reaction and strain-promoted and copper catalyzed click reactions sequentially. Our methodology can be applied to long and short nucleic acids alike, and could have broader potential for labeling other (bio-)molecules.

Entities: Chemical

Mesh：

Substances：

Year: 2018 PMID： 30277234 DOI： 10.1039/c8cc04520h

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

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Cited

7 in total

1. Developing bioorthogonal probes to span a spectrum of reactivities.

Authors: Sean S Nguyen; Jennifer A Prescher
Journal: Nat Rev Chem Date: 2020-07-21 Impact factor: 34.035

2. Nucleic Acid Conformation Influences Postsynthetic Suzuki-Miyaura Labeling of Oligonucleotides.

Authors: Manisha B Walunj; Seergazhi G Srivatsan
Journal: Bioconjug Chem Date: 2020-10-22 Impact factor: 4.774

Review 3. Covalent labeling of nucleic acids.

Authors: Nils Klöcker; Florian P Weissenboeck; Andrea Rentmeister
Journal: Chem Soc Rev Date: 2020-10-21 Impact factor: 54.564

Site-specific one-pot triple click labeling for DNA and RNA.

1. Developing bioorthogonal probes to span a spectrum of reactivities.

2. Nucleic Acid Conformation Influences Postsynthetic Suzuki-Miyaura Labeling of Oligonucleotides.

Review 3. Covalent labeling of nucleic acids.

4. Tetrazine-Ligated CRISPR sgRNAs for Efficient Genome Editing.

5. Amine-to-Azide Conversion on Native RNA via Metal-Free Diazotransfer Opens New Avenues for RNA Manipulations.

6. Analysis of GTP addition in the reverse (3'-5') direction by human tRNA^His guanylyltransferase.

Review 7. Convertible and Constrained Nucleotides: The 2'-Deoxyribose 5'-C-Functionalization Approach, a French Touch.

Site-specific one-pot triple click labeling for DNA and RNA.

1. Developing bioorthogonal probes to span a spectrum of reactivities.

2. Nucleic Acid Conformation Influences Postsynthetic Suzuki-Miyaura Labeling of Oligonucleotides.

Review 3. Covalent labeling of nucleic acids.

4. Tetrazine-Ligated CRISPR sgRNAs for Efficient Genome Editing.

5. Amine-to-Azide Conversion on Native RNA via Metal-Free Diazotransfer Opens New Avenues for RNA Manipulations.

6. Analysis of GTP addition in the reverse (3'-5') direction by human tRNAHis guanylyltransferase.

Review 7. Convertible and Constrained Nucleotides: The 2'-Deoxyribose 5'-C-Functionalization Approach, a French Touch.

6. Analysis of GTP addition in the reverse (3'-5') direction by human tRNA^His guanylyltransferase.