Hamid R Sohrabi1, Michael Weinborn1, Christoph Laske2, Kristyn A Bates3, Daniel Christensen4, Kevin Taddei1, Stephanie R Rainey-Smith1, Belinda M Brown1, Samantha L Gardener1, Simon M Laws1, Georgia Martins1, Samantha C Burnham5, Romola S Bucks6, Barry Reisberg7, Nicola T Lautenschlager8, Jonathan Foster9, Ralph N Martins1. 1. Centre of Excellence for Alzheimer's disease Research and Care, School of Medical and Health Sciences,Edith Cowan University,Joondalup, Western Australia,Australia. 2. Section for Dementia Research, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy,University of Tuebingen,Tübingen,Germany. 3. School of Animal Biology,University of Western Australia,Crawley, Western Australia,Australia. 4. Telethon Kids Institute,Subiaco, Western Australia,Australia. 5. CSIRO Floreat,Floreat, Western Australia,Australia. 6. School of Psychological Science,University of Western Australia,Crawley, Western Australia,Australia. 7. New York University Langone Medical Center,New York, NY,USA. 8. The School of Psychiatry and Clinical Neurosciences,University of Western Australia,Crawley, Western Australia,Australia. 9. School of Psychology and Speech Pathology,Curtin University,Bentley, Western Australia,Australia.
Abstract
ABSTRACTBackground:This study investigated the characteristics of subjective memory complaints (SMCs) and their association with current and future cognitive functions. METHODS: A cohort of 209 community-dwelling individuals without dementia aged 47-90 years old was recruited for this 3-year study. Participants underwent neuropsychological and clinical assessments annually. Participants were divided into SMCs and non-memory complainers (NMCs) using a single question at baseline and a memory complaints questionnaire following baseline, to evaluate differential patterns of complaints. In addition, comprehensive assessment of memory complaints was undertaken to evaluate whether severity and consistency of complaints differentially predicted cognitive function. RESULTS: SMC and NMC individuals were significantly different on various features of SMCs. Greater overall severity (but not consistency) of complaints was significantly associated with current and future cognitive functioning. CONCLUSIONS: SMC individuals present distinctive features of memory complaints as compared to NMCs. Further, the severity of complaints was a significant predictor of future cognition. However, SMC did not significantly predict change over time in this sample. These findings warrant further research into the specific features of SMCs that may portend subsequent neuropathological and cognitive changes when screening individuals at increased future risk of dementia.
ABSTRACTBackground:This study investigated the characteristics of subjective memory complaints (SMCs) and their association with current and future cognitive functions. METHODS: A cohort of 209 community-dwelling individuals without dementia aged 47-90 years old was recruited for this 3-year study. Participants underwent neuropsychological and clinical assessments annually. Participants were divided into SMCs and non-memory complainers (NMCs) using a single question at baseline and a memory complaints questionnaire following baseline, to evaluate differential patterns of complaints. In addition, comprehensive assessment of memory complaints was undertaken to evaluate whether severity and consistency of complaints differentially predicted cognitive function. RESULTS: SMC and NMC individuals were significantly different on various features of SMCs. Greater overall severity (but not consistency) of complaints was significantly associated with current and future cognitive functioning. CONCLUSIONS: SMC individuals present distinctive features of memory complaints as compared to NMCs. Further, the severity of complaints was a significant predictor of future cognition. However, SMC did not significantly predict change over time in this sample. These findings warrant further research into the specific features of SMCs that may portend subsequent neuropathological and cognitive changes when screening individuals at increased future risk of dementia.
Authors: Dona M P Jayakody; Holly K Menegola; Jessica M Yiannos; Jack Goodman-Simpson; Peter L Friedland; Kevin Taddei; Simon M Laws; Michael Weinborn; Ralph N Martins; Hamid R Sohrabi Journal: Front Neurosci Date: 2020-08-21 Impact factor: 4.677
Authors: Dona M P Jayakody; Hadeel Y Tarawneh; Holly K Menegola; Jessica M Yiannos; Peter L Friedland; Wayne J Wilson; Ralph N Martins; Hamid R Sohrabi Journal: BMJ Open Date: 2020-06-22 Impact factor: 2.692
Authors: Hadeel Y Tarawneh; Hamid R Sohrabi; Wilhelmina H A M Mulders; Ralph N Martins; Dona M P Jayakody Journal: Front Neurol Date: 2022-07-04 Impact factor: 4.086