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Literature DB >> 3027573

Deregulated c-fos expression interferes with normal bone development in transgenic mice.

U Rüther, C Garber, D Komitowski, R Müller, E F Wagner.

Abstract

Transgenic mice were generated expressing c-fos genes under the control of the human metallothionein promoter. Although high levels of c-fos messenger RNA were detectable in a variety of tissues, deregulated c-fos expression specifically interfered with normal bone development without inducing malignant tumours.

Entities: Disease Gene Species

Mesh：

Year: 1987 PMID： 3027573 DOI： 10.1038/325412a0

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

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Cited

53 in total

1. Comparative analysis of the plant mRNA-destabilizing element, DST, in mammalian and tobacco cells.

Authors: M Feldbrügge; P Arizti; M L Sullivan; P D Zamore; J G Belasco; P J Green
Journal: Plant Mol Biol Date: 2002-05 Impact factor: 4.076

2. Kaposi's sarcoma-associated herpesvirus induction of AP-1 and interleukin 6 during primary infection mediated by multiple mitogen-activated protein kinase pathways.

Authors: Jianping Xie; Hongyi Pan; Seungmin Yoo; Shou-Jiang Gao
Journal: J Virol Date: 2005-12 Impact factor: 5.103

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Authors: R Bataille; B Klein
Journal: Calcif Tissue Int Date: 1992-03 Impact factor: 4.333

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Authors: Hema Rangaswami; Nisha Marathe; Shunhui Zhuang; Yongchang Chen; Jiunn-Chern Yeh; John A Frangos; Gerry R Boss; Renate B Pilz
Journal: J Biol Chem Date: 2009-03-11 Impact factor: 5.157

Review 5. Carney complex and McCune Albright syndrome: an overview of clinical manifestations and human molecular genetics.

Authors: Paraskevi Salpea; Constantine A Stratakis
Journal: Mol Cell Endocrinol Date: 2013-09-05 Impact factor: 4.102

6. Establishment of an osteogenic cell line derived from adult mouse bone marrow stroma by use of a recombinant retrovirus.

Authors: E Mathieu; G Schoeters; F vander Plaetse; J Merregaert
Journal: Calcif Tissue Int Date: 1992-04 Impact factor: 4.333

Deregulated c-fos expression interferes with normal bone development in transgenic mice.

1. Comparative analysis of the plant mRNA-destabilizing element, DST, in mammalian and tobacco cells.

2. Kaposi's sarcoma-associated herpesvirus induction of AP-1 and interleukin 6 during primary infection mediated by multiple mitogen-activated protein kinase pathways.

3. Etiology of Paget's disease of bone: a new perspective.

4. Type II cGMP-dependent protein kinase mediates osteoblast mechanotransduction.

Review 5. Carney complex and McCune Albright syndrome: an overview of clinical manifestations and human molecular genetics.

6. Establishment of an osteogenic cell line derived from adult mouse bone marrow stroma by use of a recombinant retrovirus.

7. Insulin-like growth factor-I and insulin-like growth factor-II induce c-fos in mouse osteoblastic cells.

Review 8. Aging and the musculoskeletal system.

9. Lymphoid and mesenchymal tumors in transgenic mice expressing the v-fps protein-tyrosine kinase.

Review 10. [Model systems for investigation of genetic factors in tumorigenesis].